. "RIV/62157124:16170/12:43871260" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra" . . "Matia\u0161ovic, J\u00E1n" . "4"^^ . "6"^^ . "Tur\u00E1nek-Kn\u00F6tigov\u00E1, Pavl\u00EDna" . "O" . . . "Lev\u00E1, Lenka" . "137690" . . . . "3" . "194" . "gamadelta Lymphocytes; Chemokines; Flow cytometry; Lymphocyte subsets; Canine"@en . "Very little is known about the occurrence of immune system cells in the canine uterus. The aim of this study was to generate information about lymphocyte subsets that are present in the healthy canine uterus and that are recruited under inflammatory conditions caused by pyometra. Using immunohistochemistry and flow cytometry, a significant influx of gamadelta T lymphocytes was found in pyometra samples mainly due to recruitment of gamadelta+/CD8? T lymphocytes. The relative expression of genes encoding selected cytokines/chemokines was evaluated in samples from healthy and pyometra-affected uteri. Expression of pro-inflammatory cytokines (including IL-1beta, TNF-alfa, IL-8, IL-17 and IFN-gama) and chemokines (including CXCL10, CCL4 and CCL5) was upregulated in pyometra samples confirming the presence of inflammation. In contrast, the expression of the homeostatic chemokine CCL25 and of the anti-inflammatory cytokine IL-10 was downregulated and unchanged, respectively."@en . . . "\u0160t\u011Bp\u00E1nov\u00E1, Hana" . "1090-0233" . "Very little is known about the occurrence of immune system cells in the canine uterus. The aim of this study was to generate information about lymphocyte subsets that are present in the healthy canine uterus and that are recruited under inflammatory conditions caused by pyometra. Using immunohistochemistry and flow cytometry, a significant influx of gamadelta T lymphocytes was found in pyometra samples mainly due to recruitment of gamadelta+/CD8? T lymphocytes. The relative expression of genes encoding selected cytokines/chemokines was evaluated in samples from healthy and pyometra-affected uteri. Expression of pro-inflammatory cytokines (including IL-1beta, TNF-alfa, IL-8, IL-17 and IFN-gama) and chemokines (including CXCL10, CCL4 and CCL5) was upregulated in pyometra samples confirming the presence of inflammation. In contrast, the expression of the homeostatic chemokine CCL25 and of the anti-inflammatory cytokine IL-10 was downregulated and unchanged, respectively." . "RIV/62157124:16170/12:43871260!RIV13-MSM-16170___" . . "Vit\u00E1sek, Roman" . "Faldyna, Martin" . "Moore, Peter F." . "Veterinary Journal" . . "gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra" . "16170" . . . "gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra"@en . . . . "11"^^ . "Ondr\u00E1\u010Dkov\u00E1, Petra" . "gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra"@en . "Ore\u0161kovi\u010D, Zrinka" . . "[EB2B43032C2D]" . "Vicenov\u00E1, Monika" . . . . "Barto\u0161kov\u00E1, Alena" .