. "Ne\u010Das, Alois" . . "9" . . "Stehl\u00EDk, Ladislav" . "Swine; non-steroidal anti-inflammatory drugs; renal safety"@en . . . "P(2B06130)" . "[5CE135A6CC0F]" . "5"^^ . . "Proks, Pavel" . . "16170" . "Effect of seven-day administration of carprofen or meloxicam on renal function in clinically healthy miniature pigs" . "Rau\u0161er, Petr" . "5"^^ . "Effect of seven-day administration of carprofen or meloxicam on renal function in clinically healthy miniature pigs"@en . . "Veterin\u00E1rn\u00ED medic\u00EDna" . . "Effect of seven-day administration of carprofen or meloxicam on renal function in clinically healthy miniature pigs"@en . "RIV/62157124:16170/10:00002581" . . "RIV/62157124:16170/10:00002581!RIV11-MSM-16170___" . . . "256150" . "CZ - \u010Cesk\u00E1 republika" . "7"^^ . "55" . "0375-8427" . . "000282708500004" . . "Srnec, Robert" . . . . "Carprofen or meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs), which may elicit a variety of renal disturbances. Prior to this study, the effects of carprofen or meloxicam on renal function in pigs were unknown. A total of 21 clinically healthy Goettingen miniature pigs (36.9 - 7.22 kg) were divided into three groups based on what they were administered - carprofen, meloxicam or saline. First, blood was collected from the jugular vein and urine by ultrasound-guided cystocentesis. Serum urea (U) and creatinine (CR), fractional clearance of sodium (FCNa), urine gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities, urine protein/creatinine ratio (UP/UC), urine gamma-glutamyltransferase/creatinine ratio (GGT/CR) and urine alkaline phosphatase/creatinine ratio (ALP/CR) and urine analysis - urine specific gravity (USG) and sediment microscopy were assessed before and seven days after daily intramuscular administration (IM) of saline (1.5 ml per animal), carprofen (2 mg/kg) or" . . . "Carprofen or meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs), which may elicit a variety of renal disturbances. Prior to this study, the effects of carprofen or meloxicam on renal function in pigs were unknown. A total of 21 clinically healthy Goettingen miniature pigs (36.9 - 7.22 kg) were divided into three groups based on what they were administered - carprofen, meloxicam or saline. First, blood was collected from the jugular vein and urine by ultrasound-guided cystocentesis. Serum urea (U) and creatinine (CR), fractional clearance of sodium (FCNa), urine gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities, urine protein/creatinine ratio (UP/UC), urine gamma-glutamyltransferase/creatinine ratio (GGT/CR) and urine alkaline phosphatase/creatinine ratio (ALP/CR) and urine analysis - urine specific gravity (USG) and sediment microscopy were assessed before and seven days after daily intramuscular administration (IM) of saline (1.5 ml per animal), carprofen (2 mg/kg) or"@en . "Effect of seven-day administration of carprofen or meloxicam on renal function in clinically healthy miniature pigs" .