"[C64AC460D00C]" . "Barto\u0161\u00EDkov\u00E1, Lenka" . "0001-7213" . . . "Strnadov\u00E1, V\u011Bra" . . "Opat\u0159ilov\u00E1, Radka" . "Na devades\u00E1ti normotenzn\u00EDch laboratorn\u00EDch potkanech kmene Wistar sam\u010D\u00EDho pohlav\u00ED byly testov\u00E1ny ve \u010Dty\u0159ech rozd\u00EDln\u00FDch d\u00E1vk\u00E1ch zm\u011Bny srde\u010Dn\u00ED frekvence dvou nov\u011B syntetizovan\u00FDch potenci\u00E1ln\u00EDch ultrakr\u00E1tce p\u016Fsob\u00EDc\u00EDch antagonist\u016F beta adrenergn\u00EDch receptor\u016F. Zm\u011Bna srde\u010Dn\u00ED frekvence byla testov\u00E1ny na modelu isoprenalinem indukovan\u00E9 tachykardie. Jejich efekt byl srovn\u00E1v\u00E1n s \u00FA\u010Dinkem esmololu. Ve druh\u00E9 \u010D\u00E1sti pr\u00E1ce jsme provedli orienta\u010Dn\u00ED elektrofyziologick\u00E9 m\u011B\u0159en\u00ED vlivu testovan\u00FDch l\u00E1tek na iontov\u00E9 membr\u00E1nov\u00E9 proudy izolovan\u00FDch komorov\u00FDch kardiomyocyt\u016F in vitro. Ob\u011B l\u00E1tky vykazuj\u00ED ve v\u0161ech testovan\u00FDch koncentrac\u00EDch signifikantn\u00ED bradykardick\u00FD efekt v\u016F\u010Di placebu, ale li\u0161\u00ED se v rychlosti n\u00E1stupu \u00FA\u010Dinku. Ob\u011B nov\u011B syntetizovan\u00E9 l\u00E1tky, vyvol\u00E1vaj\u00EDc\u00ED blok\u00E1du sod\u00EDkov\u00E9ho depolariza\u010Dn\u00EDho proudu I Na a drasl\u00EDkov\u00FDch proud\u016F (I to, I K1, I K, end)."@cs . "Kolevsk\u00E1, Jana" . . "16170" . "Changes in the heart rate induced by four different doses of two newly synthesized potential ultrashort-action antagonists of beta adrenergic receptors were tested in 90 male laboratory Wistar rats. The isoprenaline-induced tachykardia model was used. Their effects were compared with those of esmolol. In the second part of the study, approximate electro-physiological measurements were made in vitro to assess the influence of the compounds tested on ion membrane currents in isolated ventricular cardiomycytes. Both compounds demonstrated significant bradycardic effects in all concentrations tested compared with the control group, but they differed in the time of the onset of their action. Both newly synthesized compounds induced blockade of the fast sodium current (I Na) and potassium currents (I to, I K1 I K,end)." . "Ultrashort bradycardic effect of newly synthesized compounds."@en . . "Kr\u010Dm\u00E1\u0159, Josef" . "RIV/62157124:16170/07:00000632!RIV08-GA0-16170___" . . "RIV/62157124:16170/07:00000632" . . "P(GA305/06/0863), P(GP203/03/D182), S" . . "Barto\u0161ov\u00E1, Ladislava" . . "Mokr\u00FD, Petr" . . "Frydrych, Marek" . "Ultrashort bradycardic effect of newly synthesized compounds." . "Acta veterinaria Brno" . . "Ultrakr\u00E1tk\u00FD bradykardick\u00FD \u00FA\u010Dinek nov\u011B syntetizovan\u00FDch slou\u010Denin"@cs . . "N" . "B\u00E9barov\u00E1, Mark\u00E9ta" . "Ultrakr\u00E1tk\u00FD bradykardick\u00FD \u00FA\u010Dinek nov\u011B syntetizovan\u00FDch slou\u010Denin"@cs . "Florian, Tom\u00E1\u0161" . . . "Ultrashort bradycardic effect of newly synthesized compounds." . "Ultrashort bradycardic effect of newly synthesized compounds."@en . . . "Vaculov\u00E1, Gabriela" . . . "CZ - \u010Cesk\u00E1 republika" . "14"^^ . "ester-functional group; membrane currents; esmolol"@en . . . . "183-196" . . "Ne\u010Das, Ji\u0159\u00ED" . . "Ber\u00E1nkov\u00E1, Kate\u0159ina" . . "N" . "456488" . . . "12"^^ . . . "Bruncl\u00EDk, V\u00EDt" . "14"^^ . "Changes in the heart rate induced by four different doses of two newly synthesized potential ultrashort-action antagonists of beta adrenergic receptors were tested in 90 male laboratory Wistar rats. The isoprenaline-induced tachykardia model was used. Their effects were compared with those of esmolol. In the second part of the study, approximate electro-physiological measurements were made in vitro to assess the influence of the compounds tested on ion membrane currents in isolated ventricular cardiomycytes. Both compounds demonstrated significant bradycardic effects in all concentrations tested compared with the control group, but they differed in the time of the onset of their action. Both newly synthesized compounds induced blockade of the fast sodium current (I Na) and potassium currents (I to, I K1 I K,end)."@en .