. . . . . . "9" . "Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level" . "[2B2C36735C51]" . "8"^^ . "http://www.agriculturejournals.cz/publicFiles/133214.pdf" . "Knoll, Ale\u0161" . . "7"^^ . "43210" . . . "Krobot, Richard" . "S" . "7"^^ . "13226" . "Roz\u00EDkov\u00E1, Veronika" . "Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level" . "344194600001" . "Komprda, Tom\u00E1\u0161" . . "Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level"@en . . "RIV/62156489:43210/14:00224199!RIV15-MSM-43210___" . . "Czech Journal of Animal Science" . "CZ - \u010Cesk\u00E1 republika" . "Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level"@en . "A hypothesis that eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) lower plasma cholesterol via increased expression of the Insig-1 gene with ensuing decrease of expression of genes coding for 3-hydroxy-3-methyl-glutaryl-CoA reductase (Hmgcr) and low density lipoprotein receptor (Ldlr) was tested in rats fed a diet with 3% of fish oil (FO). Expression of the Insig-1 gene in the liver of the FO-fed rats was 730%(P < 0.05) of the control. However, contrary to the hypothesis, expression of the Hmgcr gene and Ldlr gene was 165% and 210% of the control (P > 0.05). Nevertheless, FO in the diet decreased (P < 0.05) plasma cholesterol of rats by 10% (from 1.19 to 1.07 mmol/l); it was therefore concluded that the cholesterol-lowering effect of EPA+DHA is at least partly based on mechanisms other than tested in the present experiment."@en . . "A hypothesis that eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) lower plasma cholesterol via increased expression of the Insig-1 gene with ensuing decrease of expression of genes coding for 3-hydroxy-3-methyl-glutaryl-CoA reductase (Hmgcr) and low density lipoprotein receptor (Ldlr) was tested in rats fed a diet with 3% of fish oil (FO). Expression of the Insig-1 gene in the liver of the FO-fed rats was 730%(P < 0.05) of the control. However, contrary to the hypothesis, expression of the Hmgcr gene and Ldlr gene was 165% and 210% of the control (P > 0.05). Nevertheless, FO in the diet decreased (P < 0.05) plasma cholesterol of rats by 10% (from 1.19 to 1.07 mmol/l); it was therefore concluded that the cholesterol-lowering effect of EPA+DHA is at least partly based on mechanisms other than tested in the present experiment." . . "59" . . . "\u0160kult\u00E9ty, Ondrej" . "Vykoukalov\u00E1, Zuzana" . . "RIV/62156489:43210/14:00224199" . . "SREBP-2; Insig-1; cholesterol; PUFAn-3; rats; PPARalpha"@en . . . "Zorn\u00EDkov\u00E1, Gabriela" . . "1212-1819" . . .