"Komprda, Tom\u00E1\u0161" . "NL - Nizozemsko" . "RIV/62156489:43210/12:00184889" . "4" . . . . "10.1016/j.jff.2011.10.008" . "133611" . "Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review"@en . . "The present review summarizes the underlying biochemical and molecular mechanisms that can explain cardioprotective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their competition with arachidonic acid as a substrate of cyclooxygenase COX-2 and lipoxygenase 5-LOX, and modulation of the signaling pathways of the transcription factors peroxisome proliferator-activated receptor (PPAR), sterol-response element binding protein (SREBP) and nuclear factor jB (NF-jB). Consequences, namely decreased production of pro-inflammatory eicosanoids and cytokines, stimulation of b-oxidation, inhibition of fatty acid synthesis and down-regulation of the genes coding for enzymes of cholesterol synthesis and uptake are reviewed. Factors influencing responses of an organism to EPA/DHA intake are discussed and these include species, sex, dose and time interval of administration. Examples of food enrichment with EPA + DHAare presented under consideration of a low efficiency of conversion of a-linolenic acid to EPA (DHA)."@en . . "Journal of Functional Foods" . "43210" . "Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review" . "The present review summarizes the underlying biochemical and molecular mechanisms that can explain cardioprotective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their competition with arachidonic acid as a substrate of cyclooxygenase COX-2 and lipoxygenase 5-LOX, and modulation of the signaling pathways of the transcription factors peroxisome proliferator-activated receptor (PPAR), sterol-response element binding protein (SREBP) and nuclear factor jB (NF-jB). Consequences, namely decreased production of pro-inflammatory eicosanoids and cytokines, stimulation of b-oxidation, inhibition of fatty acid synthesis and down-regulation of the genes coding for enzymes of cholesterol synthesis and uptake are reviewed. Factors influencing responses of an organism to EPA/DHA intake are discussed and these include species, sex, dose and time interval of administration. Examples of food enrichment with EPA + DHAare presented under consideration of a low efficiency of conversion of a-linolenic acid to EPA (DHA)." . . "S" . "1756-4646" . "1"^^ . "[EBB469A03DEC]" . "14"^^ . "RIV/62156489:43210/12:00184889!RIV13-MSM-43210___" . . . "cholesterol; PUFAn-3; functional foods; SREBP; PPAR"@en . . "1" . "1"^^ . . . "Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review"@en . . . . . . "Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review" . .