. "7"^^ . . . "225310" . "RIV/62156489:43210/11:00180484!RIV15-AV0-43210___" . . "https://mnet.mendelu.cz/mendelnet2011/mendelnet_2011_fulltext.pdf" . "Adam, Vojt\u011Bch" . . "C\u00EDlem pr\u00E1ce je popsat rozd\u00EDly mezi %22zdravou%22 prostatickou tk\u00E1n\u00ED a pokro\u010Dil\u00FDm n\u00E1dorem prostaty na \u00FArovni exprese RNA a proteinu u gen\u016F, u nich\u017E literatura zmi\u0148uje zm\u011Bnu jejich hladiny, nebo je zm\u011Bna hladin p\u0159edpokl\u00E1d\u00E1na.Anal\u00FDza mo\u017En\u00FDch n\u00E1dorov\u00FDch marker\u016F byla provedena na bun\u011B\u010Dn\u00FDch lini\u00EDch, modelech (n\u00E1dorov\u011B zm\u011Bn\u011Bn\u00E9) tk\u00E1n\u011B prostaty." . . "Masa\u0159\u00EDk, Michal" . "341783400126" . "2011-01-01+01:00"^^ . . "8"^^ . "Novel prostate cancer tumour markers in a cell line model"@en . "P(GAP102/11/1068), P(KAN208130801)" . "C\u00EDlem pr\u00E1ce je popsat rozd\u00EDly mezi %22zdravou%22 prostatickou tk\u00E1n\u00ED a pokro\u010Dil\u00FDm n\u00E1dorem prostaty na \u00FArovni exprese RNA a proteinu u gen\u016F, u nich\u017E literatura zmi\u0148uje zm\u011Bnu jejich hladiny, nebo je zm\u011Bna hladin p\u0159edpokl\u00E1d\u00E1na.Anal\u00FDza mo\u017En\u00FDch n\u00E1dorov\u00FDch marker\u016F byla provedena na bun\u011B\u010Dn\u00FDch lini\u00EDch, modelech (n\u00E1dorov\u011B zm\u011Bn\u011Bn\u00E9) tk\u00E1n\u011B prostaty."@cs . "Gumulec, Jarom\u00EDr" . . "metallothionein; prostate cancer; RNA"@en . "P\u016Fvodn\u00ED znaky n\u00E1doru prostaty v modelu bun\u011B\u010Dn\u00FDch lini\u00ED" . "978-80-7375-563-8" . "43210" . "P\u016Fvodn\u00ED znaky n\u00E1doru prostaty v modelu bun\u011B\u010Dn\u00FDch lini\u00ED"@cs . "Z\u00EDtka, Ond\u0159ej" . "MendelNet 2011 - Proceedings of International Ph.D. Students Conference" . "2"^^ . . . . "Novel prostate cancer tumour markers in a cell line model"@en . "P\u016Fvodn\u00ED znaky n\u00E1doru prostaty v modelu bun\u011B\u010Dn\u00FDch lini\u00ED"@cs . "Mendel University in Brno" . "RIV/62156489:43210/11:00180484" . . "To date, it is not possible to differentiate between high-risk and latent forms of prostate cancer. The aim of this study is to determine RNA and protein level of potential tumour markers in the cell lines PNT1A and 22Rv1, which represent healthy prostate tissue and high-grade prostate cancer. We determined significantly decreased level of caveolin-1 on both RNA and protein level, which is in contradiction with our previous findings regarding to its serum level in prostate cancer patients (found increased in high-grade tumours). We also determined increased level of metallothionein on RNA and protein level in tumorous tissue, which is in agreement with previous studies focused on determination of metallothionein in serum (where increased levels were observed). Moreover, we determined significantly up-regulated RNA level of zinc(II) transporters ZIP-1 and ZnT-1. Regarding ZnT-1, such changes of expression have not been described yet. These data suggest that combination of caveolin-1, metallothionein and ZIP-1 or ZnT-1 may be utilized as a tool to distinguish aggressive forms of prostate cancer from clinically latent forms. It is expected, that such diagnostic tool is to be used for the evaluation of bioptical samples, however, verification in a large follow-up set of samples is needed."@en . "Kizek, Ren\u00E9" . "[F531025B69A8]" . . . . . "Cernei, Natalia" . "Brno" . . "Brno" . . "Babula, Petr" . "Sztalmachov\u00E1, Mark\u00E9ta" . "P\u016Fvodn\u00ED znaky n\u00E1doru prostaty v modelu bun\u011B\u010Dn\u00FDch lini\u00ED" .