"Prionov\u00E9 choroby jsou smrteln\u00E9 neurodegenerativn\u00ED a infek\u010Dn\u00EDch onemocn\u011Bn\u00ED lid\u00ED a zv\u00ED\u0159at, charakterizovan\u00E9 struktur\u00E1ln\u00EDmi p\u0159echody host-k\u00F3dovan\u00E9 bun\u011B\u010Dn\u00E9 prionov\u00E9ho proteinu (PrP c) do aberantn\u011B slo\u017Een\u00E9 patologick\u00E9 isoformy PrPSc. Prionov\u00E9ho proteinu je p\u0159irozen\u011B se vyskytuj\u00EDc\u00ED molekuly v \u017Eivo\u010Di\u0161n\u00FDch bun\u011Bk. Tento protein je p\u0159\u00EDtomen ve v\u0161ech sav\u010D\u00EDch bu\u0148k\u00E1ch a vyskytuje se p\u0159edev\u0161\u00EDm v nervov\u00E9 bu\u0148ky a bun\u011Bk imunitn\u00EDho syst\u00E9mu. Hlavn\u00EDm c\u00EDlem t\u00E9to studie bylo optimalizovat elektrochemick\u00E9 metody Detekce p\u0159\u00EDrodn\u00EDch (PrP c) a zm\u011Bnil (PrPSc) prionov\u00E9ho proteinu. Pro proveden\u00ED hlavn\u00EDm c\u00EDlem komplexn\u00ED studium elektrochemick\u00E9 chov\u00E1n\u00ED obou protein\u016F byla zapot\u0159eb\u00ED. Za t\u00EDmto \u00FA\u010Delem Z\u00E1kladn\u00ED elektrochemick\u00E9 metody byly pou\u017Eity. Oba priony jsou charakterizov\u00E1ny r\u016Fzn\u00FDch technik, jejich meze detekce byly nalezeny v pM \u00FArovn\u00EDch a lze mo\u017Enost zm\u011Bny strukturu a-helix p\u0159\u00EDrodn\u00EDch prion (PrP c) k b-list infek\u010Dn\u00ED prion (PrPSc) byly sledovat."@cs . "3"^^ . "neurodegenerative; prion protein; electrochemical techniques"@en . "RIV/62156489:43210/11:00180472!RIV15-AV0-43210___" . . . . "978-80-7375-563-8" . "[AE5248877EC9]" . "3"^^ . "Mendel University in Brno" . . "MendelNet 2011 - Proceedings of International Ph.D. Students Conference" . "Adam, Vojt\u011Bch" . "341783400102" . "R\u016Fzn\u00E9 elektrochemick\u00E9 metody pro stanoven\u00ED prionov\u00E9ho proteinu"@cs . "Kizek, Ren\u00E9" . . "6"^^ . "\u0160obrov\u00E1, Pavl\u00EDna" . . . "Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. Prion protein is a biomolecule naturally occurring in the animal cells. This protein is present in all mammal cells and occurs primarily in neural cells and immune system cells. The main aim of this study was to optimize electrochemical methods for the detection of natural (PrPC) and changed (PrPSC) prion protein. To carry out the main objective a complex study of the electrochemical behaviour of both proteins was required. For this purpose fundamental electrochemical techniques were used. Both of the prions were characterized using different techniques, their limits of detection were found at pM levels and possible ability to change the structure of a-helix of natural prion (PrPC) to b-sheet of the infectious prion (PrPSc) were monitored."@en . . . "P(GAP102/11/1068), P(KAN208130801)" . "RIV/62156489:43210/11:00180472" . . "R\u016Fzn\u00E9 elektrochemick\u00E9 metody pro stanoven\u00ED prionov\u00E9ho proteinu" . "43210" . . "https://mnet.mendelu.cz/mendelnet2011/mendelnet_2011_fulltext.pdf" . . . "Various electrochemical techniques for prion protein determination"@en . . . . . "2011-01-01+01:00"^^ . "R\u016Fzn\u00E9 elektrochemick\u00E9 metody pro stanoven\u00ED prionov\u00E9ho proteinu"@cs . "Brno" . "Various electrochemical techniques for prion protein determination"@en . "R\u016Fzn\u00E9 elektrochemick\u00E9 metody pro stanoven\u00ED prionov\u00E9ho proteinu" . "Brno" . . "Prionov\u00E9 choroby jsou smrteln\u00E9 neurodegenerativn\u00ED a infek\u010Dn\u00EDch onemocn\u011Bn\u00ED lid\u00ED a zv\u00ED\u0159at, charakterizovan\u00E9 struktur\u00E1ln\u00EDmi p\u0159echody host-k\u00F3dovan\u00E9 bun\u011B\u010Dn\u00E9 prionov\u00E9ho proteinu (PrP c) do aberantn\u011B slo\u017Een\u00E9 patologick\u00E9 isoformy PrPSc. Prionov\u00E9ho proteinu je p\u0159irozen\u011B se vyskytuj\u00EDc\u00ED molekuly v \u017Eivo\u010Di\u0161n\u00FDch bun\u011Bk. Tento protein je p\u0159\u00EDtomen ve v\u0161ech sav\u010D\u00EDch bu\u0148k\u00E1ch a vyskytuje se p\u0159edev\u0161\u00EDm v nervov\u00E9 bu\u0148ky a bun\u011Bk imunitn\u00EDho syst\u00E9mu. Hlavn\u00EDm c\u00EDlem t\u00E9to studie bylo optimalizovat elektrochemick\u00E9 metody Detekce p\u0159\u00EDrodn\u00EDch (PrP c) a zm\u011Bnil (PrPSc) prionov\u00E9ho proteinu. Pro proveden\u00ED hlavn\u00EDm c\u00EDlem komplexn\u00ED studium elektrochemick\u00E9 chov\u00E1n\u00ED obou protein\u016F byla zapot\u0159eb\u00ED. Za t\u00EDmto \u00FA\u010Delem Z\u00E1kladn\u00ED elektrochemick\u00E9 metody byly pou\u017Eity. Oba priony jsou charakterizov\u00E1ny r\u016Fzn\u00FDch technik, jejich meze detekce byly nalezeny v pM \u00FArovn\u00EDch a lze mo\u017Enost zm\u011Bny strukturu a-helix p\u0159\u00EDrodn\u00EDch prion (PrP c) k b-list infek\u010Dn\u00ED prion (PrPSc) byly sledovat." . . "227969" .