"0378-4274" . . . . . "Adam, Vojt\u011Bch" . "V\u00FDzkum role metalothioneinu v rezistenci na platinov\u00E1 cytostaika"@cs . "4"^^ . "K\u0159\u00ED\u017Ekov\u00E1, So\u0148a" . . . "In this work, we employed electroanalytical methods for determination of metallothionein (MT) in cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines, blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. In addition, we were interested in the effect of cisplatin or carboplatin treatment of patients with a tumour disease. At patients with tumour in head and neck area treated with cisplatin we observed that the level of MT was going higher due to administration of the drug. However, at retinoblastoma patients treated with carboplatin we observed various phenomena including decreasing, increasing or no changes in MT level." . . "[B3752FF4A80F]" . . "Investigation of a role of metallothionein in resistance on platinum based cytostatics"@en . "373192" . "Investigation of a role of metallothionein in resistance on platinum based cytostatics" . "Pr\u016F\u0161a, Richard" . "NL - Nizozemsko" . "9"^^ . "Hrab\u011Bta, Jan" . "RIV/62156489:43210/08:00133458" . "Fabrik, Ivo" . "V\u00FDzkum role metalothioneinu v rezistenci na platinov\u00E1 cytostaika"@cs . "P(IAA401990701)" . "Eckschlager, Tom\u00E1\u0161" . . . "V t\u00E9to pr\u00E1ci jeme u\u017Eily elektrochemickou metodu pro stanoven\u00ED metalothioneinu v senzitivn\u00ED a rezistentn\u00ED neuroblastomov\u00E9 bun\u011B\u010Dn\u00E9 lini ke karboplatin\u011B a cisplatin\u011B, v krevn\u00EDm s\u00E9ru pacient\u016F s n\u00E1dory krku a hlavy nebo retinoblastem a my\u0161\u00EDch vystaven\u00FDch cisplatin\u011B. A zam\u011B\u0159ili jsme se na roli metalothioneinu ve vzniku rezistence k l\u00E9\u010Db\u011B zalo\u017Een\u00E9 na cytostatic\u00EDch na b\u00E1zi t\u011B\u017Ek\u00FDch kov\u016F. Zjistili jsme zaj\u00EDmav\u00FD efekt u cisplatinou a karboplatinou l\u00E9\u010Den\u00FDch pacient\u016F s n\u00E1dorov\u00FDm onemocn\u011Bn\u00EDm. Pacienti s n\u00E1dory halvi a krku m\u011Bli po l\u00E9\u010Db\u011B vy\u0161\u0161\u00ED hladinu metalothioeniunu, zat\u00EDm co pacienti s retinoblastomem nastalo sn\u00ED\u017Een\u00ED, zv\u00FD\u0161en\u00ED a nebo \u017E\u00E1dn\u00E1 zm\u011Bna v obsahu MT."@cs . "180" . . "Investigation of a role of metallothionein in resistance on platinum based cytostatics" . "43210" . "Investigation of a role of metallothionein in resistance on platinum based cytostatics"@en . "Kukacka, J." . . "H\u00FAska, Dalibor" . . "cisplatin; drugs resistant; carboplatina"@en . "1" . . . . "In this work, we employed electroanalytical methods for determination of metallothionein (MT) in cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines, blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. In addition, we were interested in the effect of cisplatin or carboplatin treatment of patients with a tumour disease. At patients with tumour in head and neck area treated with cisplatin we observed that the level of MT was going higher due to administration of the drug. However, at retinoblastoma patients treated with carboplatin we observed various phenomena including decreasing, increasing or no changes in MT level."@en . "Toxicology Letters" . . "RIV/62156489:43210/08:00133458!RIV09-AV0-43210___" . . "Kizek, Ren\u00E9" . "1"^^ .