"In the present paper we employed adsorptive transfer stripping technique coupled with chronopotentiometric stripping analysis for determination of metallothionein (MT) in tumor cell lines and differential pulse voltammetry Brdicka reaction for determination of MT in blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. The cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines were derived from the maternal cell line isolated from the bone metastasis of patients with neuroblastoma. Based on the results obtained it can be concluded that level of MT increases with higher dose of platinum based" . . . "8"^^ . . "C\u00EDlem t\u00E9to pr\u00E1ce bylo vyu\u017E\u00EDt adsorbtivn\u00ED p\u0159enosovou techniku rozpou\u0161t\u011Bc\u00ED chronopotenciometrick\u00E9 anal\u00FDzi pro stanoven\u00ED metalothioneinu v krevn\u00EDm s\u00E9ru pacient\u016F s n\u00E1dory krku a hlavy p\u0159\u00EDpadn\u011B pacient\u016F s retoblastomema a my\u0161\u00ED po aplikaci cysplatiny. D\u00E1le stanoven\u00ED metalothioneinu v n\u00E1dorov\u00FDch bun\u011B\u010Dn\u00FDch lini\u00EDch. B\u016Fn\u011B\u010Dn\u00E9 linie byly izolov\u00E1ny od pacient\u016F s neuroblastomi. Na z\u00E1klad\u011B v\u00FDsledk\u016F jsem vyslovili z\u00E1v\u011Br, \u017Ee hladina metalothioneinu se zvy\u0161uje po vy\u0161\u00ED d\u00E1vce cisplatiny."@cs . . "Elektrochemick\u00E9 techniky pro stanoven\u00ED metalothioneinu v tumorov\u00FDch bun\u011B\u010Dn\u00FDch lini\u00EDch a pacient\u016F s n\u00E1dorov\u00FDm onemocn\u011Bn\u00EDm"@cs . "H\u00FAska, Dalibor" . "Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease"@en . . . "K\u0159\u00ED\u017Ekov\u00E1, So\u0148a" . "cisplatin; metallothionein"@en . . "Adam, Vojt\u011Bch" . "4"^^ . . "20" . . "RIV/62156489:43210/08:00133063!RIV09-AV0-43210___" . "Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease"@en . "14" . "Fabrik, Ivo" . . . "43210" . "Electroanalysis" . "In the present paper we employed adsorptive transfer stripping technique coupled with chronopotentiometric stripping analysis for determination of metallothionein (MT) in tumor cell lines and differential pulse voltammetry Brdicka reaction for determination of MT in blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. The cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines were derived from the maternal cell line isolated from the bone metastasis of patients with neuroblastoma. Based on the results obtained it can be concluded that level of MT increases with higher dose of platinum based"@en . . "P(IAA401990701)" . "Trnkov\u00E1, Libu\u0161e" . . . "Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease" . . "Elektrochemick\u00E9 techniky pro stanoven\u00ED metalothioneinu v tumorov\u00FDch bun\u011B\u010Dn\u00FDch lini\u00EDch a pacient\u016F s n\u00E1dorov\u00FDm onemocn\u011Bn\u00EDm"@cs . "Hub\u00E1lek, Jarom\u00EDr" . . "RIV/62156489:43210/08:00133063" . "Kizek, Ren\u00E9" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "12"^^ . "1040-0397" . "Pr\u016F\u0161a, Richard" . "[18CC268948E6]" . "Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease" . . "366105" .