"1" . "Funk, Petr" . . "000288062600007" . "ACS Combinatorial Science" . . . . "A structure-activity relationship of some derivatives of 2-phenylsubstituted-3-hydroxyquinolin-4(1H)-one-7-carboxamides was systematically studied using combinatorial solid-phase synthesis and in vitro cytotoxic activity screening on representative cancer lines. The effect of substituent type in position 2 as well as of the carboxamide group was investigated via synthesis of generic libraries constructed with respect to polarity and bulkiness of appropriate substituents. The process of development afforded a set of compounds with significant cytotoxic activity. Subsequently, corresponding 2-phenylsubstituted-3-hydroxyquinolin-4(1H)-one-6-carboxamides and 2-phenylsubstituted-3-hydroxyquinolin-4(1H)-one-8-carboxamides were prepared to evaluate the influence of the carboxamide group position on the resulting biological activity."@en . . . . "3"^^ . "RIV/61989592:15310/11:33118331!RIV12-MSM-15310___" . "D\u017Eub\u00E1k, Petr" . . . . . "6"^^ . . "244009" . "[FC5D92363E26]" . . "RIV/61989592:15310/11:33118331" . "Soural, Miroslav" . . . "2-Phenylsubstituted-3-Hydroxyquinolin-4(1H)-one-Carboxamides: Structure-Cytotoxic Activity Relationship Study"@en . . "Hajd\u00FAch, Mari\u00E1n" . . "13" . . "P(ED0030/01/01), P(ME09057), Z(MSM6198959216)" . "15310" . "Hydroxyquinolinones, Solid-phase synthesis, combinatorial chemistry, Cytotoxicity, Structure-activity relationship"@en . . . "2156-8952" . "Hlav\u00E1\u010D, Jan" . "10.1021/co100013t" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "2-Phenylsubstituted-3-Hydroxyquinolin-4(1H)-one-Carboxamides: Structure-Cytotoxic Activity Relationship Study"@en . "2-Phenylsubstituted-3-Hydroxyquinolin-4(1H)-one-Carboxamides: Structure-Cytotoxic Activity Relationship Study" . . . "2-Phenylsubstituted-3-Hydroxyquinolin-4(1H)-one-Carboxamides: Structure-Cytotoxic Activity Relationship Study" . "5"^^ . "A structure-activity relationship of some derivatives of 2-phenylsubstituted-3-hydroxyquinolin-4(1H)-one-7-carboxamides was systematically studied using combinatorial solid-phase synthesis and in vitro cytotoxic activity screening on representative cancer lines. The effect of substituent type in position 2 as well as of the carboxamide group was investigated via synthesis of generic libraries constructed with respect to polarity and bulkiness of appropriate substituents. The process of development afforded a set of compounds with significant cytotoxic activity. Subsequently, corresponding 2-phenylsubstituted-3-hydroxyquinolin-4(1H)-one-6-carboxamides and 2-phenylsubstituted-3-hydroxyquinolin-4(1H)-one-8-carboxamides were prepared to evaluate the influence of the carboxamide group position on the resulting biological activity." .