. "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "6"^^ . "3" . . "Gibala, Petr" . . . "Journal of Pharmaceutical and Biomedical Analysis" . . "A rapid procedure based on direct extraction and RP-HPLC separation of pregabalin and its possible impurities with fluorescence detection has been developed. The separation conditions and parameters of derivatization reaction for postcolumn derivatization of pregabalin with o-phtaldialdehyde/2-mercaptoethanol were studied. Purospher STAR RP-8e column with isocratic elution was employed Fluorescence detection was performed at excitation and emission wavelength of 345 nm and 450 nm, respectively The proposed method has an advantage of a simple sample pre-treatment and a quick and very sensitive HPLC method. The applicability of developed method was successfully verified during analysis of commercial samples of tablets of Lyrica (Pfizer, USA)." . "000280435800067" . "15310" . . "Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde" . "RIV/61989592:15310/10:10215688" . "Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde"@en . . "Z(MSM6198959216)" . . . . . "RIV/61989592:15310/10:10215688!RIV11-MSM-15310___" . "3"^^ . . . . "1"^^ . . "A rapid procedure based on direct extraction and RP-HPLC separation of pregabalin and its possible impurities with fluorescence detection has been developed. The separation conditions and parameters of derivatization reaction for postcolumn derivatization of pregabalin with o-phtaldialdehyde/2-mercaptoethanol were studied. Purospher STAR RP-8e column with isocratic elution was employed Fluorescence detection was performed at excitation and emission wavelength of 345 nm and 450 nm, respectively The proposed method has an advantage of a simple sample pre-treatment and a quick and very sensitive HPLC method. The applicability of developed method was successfully verified during analysis of commercial samples of tablets of Lyrica (Pfizer, USA)."@en . "268619" . . "Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde"@en . "Dou\u0161a, Michal" . "0731-7085" . "[603C26D27B58]" . "Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde" . "Postcolumn derivatization; Phamaceutical formulation; Validation; Pregabalin; Reversed-phase separation; HPLC"@en . . "Lemr, Karel" . . "53" .