"6" . . . "Soural, Miroslav" . "Solid-phase Synthesis of Highly Diverse Purine-Hydroxyquinolinone Bisheterocycles" . "3"^^ . . . . . . "Journal of Combinatorial Chemistry" . . . "Solid-phase synthesis of bisheterocyclic compounds that contain purine and 3-hydroxyquinolin-4(1H)-one skeleton connected with an aliphatic spacer of a different length/structure is described. The reaction sequence started from the primary amines immobilized on aminomethylated polystyrene resin equipped with BAL linker. After the arylation of amines with 2,6-dichloropurine via its C6, purine N9 was alkylated and subsequently the chlorine atom at purine C2 was substituted with aliphatic diamines. The resulting terminal aminogroup was used as the starting point for the synthesis of 3-hydroxyquinolin-4(1H)-one precursores based on the acylation with 1-methyl-2-aminoterephtalate followed by the saponification of the methyl ester and esterification of the resulting carboxylic acid with various haloketones. The intermediates were cleaved from the resin and their cyclisation to the target purine-hydroxyquinolinone bisheterocycles was accomplished by heating in acetic or trifluoroacetic acid."@en . . "Solid-phase Synthesis of Highly Diverse Purine-Hydroxyquinolinone Bisheterocycles"@en . . . "5"^^ . . "[0F2457EA901E]" . . . "Hlav\u00E1\u010D, Jan" . . "Solid-phase Synthesis of Highly Diverse Purine-Hydroxyquinolinone Bisheterocycles" . . "Hydroxyquinolinones, Purines, Bisheterocycles, Solid-phase synthesis"@en . "Va\u0148kov\u00E1, Barbora" . . "12" . "RIV/61989592:15310/10:10215444!RIV11-MSM-15310___" . "288507" . "1520-4766" . "RIV/61989592:15310/10:10215444" . "Solid-phase Synthesis of Highly Diverse Purine-Hydroxyquinolinone Bisheterocycles"@en . "P(ME09057), Z(MSM6198959216)" . . "15310" . . "Solid-phase synthesis of bisheterocyclic compounds that contain purine and 3-hydroxyquinolin-4(1H)-one skeleton connected with an aliphatic spacer of a different length/structure is described. The reaction sequence started from the primary amines immobilized on aminomethylated polystyrene resin equipped with BAL linker. After the arylation of amines with 2,6-dichloropurine via its C6, purine N9 was alkylated and subsequently the chlorine atom at purine C2 was substituted with aliphatic diamines. The resulting terminal aminogroup was used as the starting point for the synthesis of 3-hydroxyquinolin-4(1H)-one precursores based on the acylation with 1-methyl-2-aminoterephtalate followed by the saponification of the methyl ester and esterification of the resulting carboxylic acid with various haloketones. The intermediates were cleaved from the resin and their cyclisation to the target purine-hydroxyquinolinone bisheterocycles was accomplished by heating in acetic or trifluoroacetic acid." . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "000283810600014" . "3"^^ .