"The invention relates to 3-,5-,7-trisubstituted pyrazolo(4,3-d)pyrimidines represented by the general formula (I), and substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl, alkyl, aryl or alkylaryl group, R5 is halogen, -NHNH2, -NHOH, NHCONH2, guanylo (NH-C(NH)NH2) an optionally substituted C1-C6 alkyl, alkenyl, alkinyl, C3-C15 cycloalkyl, Rf (C3-C15 cycloalkyl), heterocycle, heteroalkyl, aryl, heteroaryl, arylalkyl, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkyl group etc.This invention relates to new pyrazolo(4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. More specifically, the present invention also relates to the use of 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines or a pharmaceutically acceptable salt thereof in combination with cytostatics in the preparation of a medicament for treating cancer."@en . . "Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy"@en . "novel, pyrazolo[4,3-D]pyrimidines, process, preparation, method, therapy"@en . "Moravcov\u00E1, Daniela" . . "Lenobel, Ren\u00E9" . . . "Gatineau" . . . . . "HAVL\u00CD\u010CEK, Libor" . . . "Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy" . "275450" . "Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy"@en . . "Canadian Intellectual Property Office (CIPO) Industry Canada" . . "Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy" . . "Kry\u0161tof, Vladim\u00EDr" . . . . . "4"^^ . . . "15310" . . . . . "Univerzita Palack\u00E9ho v Olomouci a \u00DAstav Experiment\u00E1ln\u00ED Botaniky AV \u010CR v Praze" . . . . "P(GA301/08/1649), P(GA522/09/1576), Z(AV0Z5038910)" . "RIV/61989592:15310/10:10212652!RIV11-GA0-15310___" . . . "[E4138C0AA5E8]" . "5"^^ . "The invention relates to 3-,5-,7-trisubstituted pyrazolo(4,3-d)pyrimidines represented by the general formula (I), and substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl, alkyl, aryl or alkylaryl group, R5 is halogen, -NHNH2, -NHOH, NHCONH2, guanylo (NH-C(NH)NH2) an optionally substituted C1-C6 alkyl, alkenyl, alkinyl, C3-C15 cycloalkyl, Rf (C3-C15 cycloalkyl), heterocycle, heteroalkyl, aryl, heteroaryl, arylalkyl, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkyl group etc.This invention relates to new pyrazolo(4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. More specifically, the present invention also relates to the use of 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines or a pharmaceutically acceptable salt thereof in combination with cytostatics in the preparation of a medicament for treating cancer." . "RIV/61989592:15310/10:10212652" . . . "2010-06-22+02:00"^^ . "CA2480409" . . "Strnad, Miroslav" .