. "51" . "10"^^ . . "Brabec, Viktor" . . "Ka\u0161p\u00E1rkov\u00E1, Jana" . "17" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "0022-2623" . "Sadler, Peter" . "P(1QS500040581), P(GA203/06/1239), P(IAA400040803), P(KAN200200651), P(LC06030), P(ME08017), P(NR8562), P(OC08003), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM6198959216)" . "Pardone, Simon" . "Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes"@en . "RIV/61989592:15310/08:00005500" . . . . "361899" . . "Hal\u00E1mikov\u00E1, Anna" . "RIV/61989592:15310/08:00005500!RIV10-MSM-15310___" . . "We have compared the cancer cell cytotoxicity, cell uptake, and DNA binding properties of the isomeric terphenyl complexes [(6-arene)Ru(en)Cl]+, where the arene is ortho- (2), meta- (3), or para-terphenyl (1) (o-, m-, or p-terp). Complex 1, the X-ray crystal structure of which confirms that it has the classical ?piano-stool? geometry, has a similar potency to cisplatin but is not cross-resistant and has a much higher activity than 2 or 3. The extent of Ru uptake into A2780 or A2780cis cells does not correlate with potency. Complex 1 binds to DNA rapidly and quantitatively, preferentially to guanine residues, and causes significant DNA unwinding. Circular and linear dichroism, competitive binding experiments with ethidium bromide, DNA melting, and surface-enhanced Raman spectroscopic data are consistent with combined intercalative and monofunctional (coordination) binding mode of complex 1. This unusual DNA binding mode may therefore make a major contribution to the high potency of complex 1." . . "Zerz\u00E1nkov\u00E1, Lenka" . . . . "15310" . "Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes" . . "Bugarcic, Tijana" . "We have compared the cancer cell cytotoxicity, cell uptake, and DNA binding properties of the isomeric terphenyl complexes [(6-arene)Ru(en)Cl]+, where the arene is ortho- (2), meta- (3), or para-terphenyl (1) (o-, m-, or p-terp). Complex 1, the X-ray crystal structure of which confirms that it has the classical ?piano-stool? geometry, has a similar potency to cisplatin but is not cross-resistant and has a much higher activity than 2 or 3. The extent of Ru uptake into A2780 or A2780cis cells does not correlate with potency. Complex 1 binds to DNA rapidly and quantitatively, preferentially to guanine residues, and causes significant DNA unwinding. Circular and linear dichroism, competitive binding experiments with ethidium bromide, DNA melting, and surface-enhanced Raman spectroscopic data are consistent with combined intercalative and monofunctional (coordination) binding mode of complex 1. This unusual DNA binding mode may therefore make a major contribution to the high potency of complex 1."@en . . "Habtemariam, Abraha" . . "Journal of Medicinal Chemistry" . "Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes" . "2"^^ . . . "Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes"@en . . . "DNA interactions; ruthenium; anticancer"@en . . . . . "Vr\u00E1na, Old\u0159ich" . . "10"^^ . "[C5058A8D90C1]" . . "Nov\u00E1kov\u00E1, Olga" . .