"GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "1475-6366" . "N\u011Bkolik N6-alkylaminoadenin\u016F bylo p\u0159ipraveno jako trihydrochloridy v dostate\u010Dn\u00E9 \u010Distot\u011B pro dal\u0161\u00ED studia - ABAD, N6-(4-aminobutyl)adenin, ABYAD, N6-(4-aminobut-2-ynyl)adenin, ACBAD, N6-(4-amino-cis-but-2-enyl)adenin, APAD, N6-(3- aminopropyl)-adenin a ATBAD, N6-(4-amino-trans-but-2-enyl)adenin. Tyto l\u00E1tky byly pln\u011B charakterizov\u00E1ny a testov\u00E1ny s enzymy GPAO - aminoxidasa z hrachoru set\u00E9ho, ELAO - aminoxidasa z latexu Euphorbia characias, LSAO - aminoxidasa z \u010Do\u010Dky. P\u0159\u00EDtomnost adeninov\u00E9ho cyklu nebr\u00E1n\u00ED interakci s enzymem. ABAD i ATBAD mohou b\u00FDt pova\u017Eov\u00E1ny za substr\u00E1ty. Hodnoty Km t\u011Bchto l\u00E1tek se bl\u00ED\u017E\u00ED hodnot\u00E1m zn\u00E1m\u00FDm pro subtr\u00E1t putrescin, a\u010Dkoli l\u00E1tky jev\u00ED odli\u0161nou stechiometrii reakce. APAD a ACBAD se projevuj\u00ED jako reverzibiln\u00ED inhibitory, \u010D\u00EDm\u017E se ACBAD li\u0161\u00ED od sv\u00E9ho geometrick\u00E9ho izomeru ATBAD. ABYAD je reak\u010Dn\u011B z\u00E1visl\u00FDm inhibitorem zkouman\u00FDch aminoxidas. Experimenty s rychl\u00FDm zaznamen\u00E1v\u00E1n\u00EDm spekter uk\u00E1zaly, \u017Ee ACBAD a APAD netvo\u0159\u00ED p\u0159i enyzmov\u00E9 p\u0159em\u011Bn\u011B meziprodukty typick\u00E9 pro substr\u00E1ty aminoxidas"@cs . "Medda, Rosaria" . "143-151" . "RIV/61989592:15310/05:00002183!RIV06-MSM-15310___" . "Reakce rostlinn\u00FDch Cu-aminoxidas s N6-aminoalkylderiv\u00E1ty adeninu"@cs . "[E8CE778A2583]" . . "20" . . "Z(MSM 153100010), Z(MSM 153100013)" . "Reactions of plant copper/topaquinone amine oxidases with N6-aminoalkyl derivatives of adenine" . . "Longu, Silvia" . . . . "Pe\u010D, Pavel" . "8"^^ . "CYCLIN-DEPENDENT KINASES; PEA DIAMINE OXIDASE; CYTOKININ OXIDASE; MECHANISM; INHIBITION; OLOMOUCINE; SEEDLINGS; DEHYDROGENASE; INACTIVATION; PURIFICATION"@en . "Padiglia, Alessandra" . . . . "9"^^ . . . "Floris, Giovanni" . "Reactions of plant copper/topaquinone amine oxidases with N6-aminoalkyl derivatives of adenine" . . "Fry\u010D\u00E1k, Petr" . . "2" . "Reakce rostlinn\u00FDch Cu-aminoxidas s N6-aminoalkylderiv\u00E1ty adeninu"@cs . "Journal of Enzyme Inhibition and Medicinal Chemistry" . . "\u0160ebela, Marek" . . "3"^^ . "Reactions of plant copper/topaquinone amine oxidases with N6-aminoalkyl derivatives of adenine"@en . . . "Plant copper/topaquinone-containing amine oxidases (CAOs, EC 1.4.3.6) are enzymes oxidising various amines. Here wereport a study on the reactions of CAOs from grass pea (Lathyrus sativus), lentil (Lens esculenta) and Euphorbia characias, aMediterranean shrub, with N6-aminoalkyl adenines representing combined analogues of cytokinins and polyamines. Thefollowing compounds were synthesised: N6-(3-aminopropyl)adenine, N6-(4-aminobutyl)adenine, N6-(4-amino-trans-but-2-enyl)adenine, N6-(4-amino-cis-but-2-enyl)adenine and N6-(4-aminobut-2-ynyl)adenine. From these, N 6-(4-aminobutyl)adenine and N6-(4-amino-trans-but-2-enyl)adenine were found to be substrates for all three enzymes (Km similar to 10-4 M).Absorption spectroscopy demonstrated such an interaction with the cofactor topaquinone, which is typical for commondiamine substrates. However, only the former compound provided a regular reaction stoichiometry. Anaerobic absorptionspectra of N6-(3-aminopropyl)adenine, N6-(4-amino-cis-but-2-enyl)adenine and N6" . "RIV/61989592:15310/05:00002183" . "15310" . "Lamplot, Zbyn\u011Bk" . . . "Reactions of plant copper/topaquinone amine oxidases with N6-aminoalkyl derivatives of adenine"@en . "540083" . . . . "Plant copper/topaquinone-containing amine oxidases (CAOs, EC 1.4.3.6) are enzymes oxidising various amines. Here wereport a study on the reactions of CAOs from grass pea (Lathyrus sativus), lentil (Lens esculenta) and Euphorbia characias, aMediterranean shrub, with N6-aminoalkyl adenines representing combined analogues of cytokinins and polyamines. Thefollowing compounds were synthesised: N6-(3-aminopropyl)adenine, N6-(4-aminobutyl)adenine, N6-(4-amino-trans-but-2-enyl)adenine, N6-(4-amino-cis-but-2-enyl)adenine and N6-(4-aminobut-2-ynyl)adenine. From these, N 6-(4-aminobutyl)adenine and N6-(4-amino-trans-but-2-enyl)adenine were found to be substrates for all three enzymes (Km similar to 10-4 M).Absorption spectroscopy demonstrated such an interaction with the cofactor topaquinone, which is typical for commondiamine substrates. However, only the former compound provided a regular reaction stoichiometry. Anaerobic absorptionspectra of N6-(3-aminopropyl)adenine, N6-(4-amino-cis-but-2-enyl)adenine and N6"@en . . . .