. "Swaczynov\u00E1, Jana" . "We have developed a monoclonal antibodies against synthetic compound of cytokinin class: 2-OH-3-OCH3-BAPR, which showed promising in-vitro anti-cancer properties. The use of prepared columns for immunoaffinity purification of the real samples is demonstrated in this study."@en . "Lenobel, Ren\u00E9" . "RIV/61989592:15310/04:00002313" . . . . "9" . "V\u00FDvoj imunoafinitn\u00ED chromatografie pro nov\u00E9 deriv\u00E1ty 6-benzylaminopurinu" . "[5F39451DBD64]" . "4"^^ . . "V\u00FDvoj imunoafinitn\u00ED chromatografie pro nov\u00E9 deriv\u00E1ty 6-benzylaminopurinu"@cs . . . "V\u00FDvoj imunoafinitn\u00ED chromatografie pro nov\u00E9 deriv\u00E1ty 6-benzylaminopurinu" . "3"^^ . "15310" . "Development of imunoaffinity chromatography for new benzylaminopurine derivatives"@en . . "Hauserov\u00E1, Eva" . . "CZ - \u010Cesk\u00E1 republika" . "594390" . "Cytokininy pat\u0159\u00ED do skupiny fytohormon\u016F1. Struktur\u00E1ln\u011B vych\u00E1z\u00ED tyto l\u00E1tky z adeninu substituovan\u00E9ho na exocyklick\u00E9 aminoskupin\u011B v poloze N-6. P\u0159irozen\u011B se vyskytuj\u00EDc\u00ED cytokininy existuj\u00ED ve form\u011B baz\u00ED, N-glykosid\u016F, O-glukosid\u016F a ribotid\u016F. U rostlin reguluj\u00ED celou \u0159adu d\u016Fle\u017Eit\u00FDch fyziologick\u00FDch proces\u016F (stimulace bun\u011B\u010Dn\u00E9ho d\u011Blen\u00ED, zpomalen\u00ED st\u00E1rnut\u00ED atd.). Jednou z nej\u00FA\u010Dinn\u011Bj\u0161\u00EDch l\u00E1tek z t\u00E9to skupiny je 6-benzylaminopurin.N\u011Bkter\u00E9 jeho syntetick\u00E9 deriv\u00E1ty (trisubstituovan\u00E9 puriny olomoucin, bohemin, roskovitin, purvalanol A) jsou zn\u00E1my jako specifick\u00E9 inhibitory proteinkinas cdk (cyklin-dependentn\u00ED kinasa). Cyklin-dependentn\u00ED kinasy jsou zodpov\u011Bdn\u00E9 za fosforylaci protein\u016F v bun\u011B\u010Dn\u00E9m cyklu a jejich inhibice m\u016F\u017Ee v\u00E9st a\u017E k apopt\u00F3ze2,3. Slou\u010Deniny purinov\u00E9ho charakteru jsou tak potencion\u00E1ln\u00EDmi protin\u00E1dorov\u00FDmi l\u00E1tkami. U jin\u00E9ho synteticky p\u0159ipraven\u00E9ho deriv\u00E1tu benzylaminopurinu, 6-(2-hydroxy-3-methoxybenzylamino)purin-9-\u00DF-ribosidu, (2-OH-3-OCH3-BAPR), byla prok\u00E1z\u00E1na vysok\u00E1 cytotoxicita proti CEM a HL" . . "cytokinins;antibodies;immunoaffinity chromatography"@en . "P(KJB6137301)" . "V\u00FDvoj imunoafinitn\u00ED chromatografie pro nov\u00E9 deriv\u00E1ty 6-benzylaminopurinu"@cs . . "679" . . "Development of imunoaffinity chromatography for new benzylaminopurine derivatives"@en . . "RIV/61989592:15310/04:00002313!RIV/2005/AV0/153105/N" . . . . "0009-2770" . . "366"^^ . "Dole\u017Eal, Karel" . "98" . "Chemick\u00E9 listy" . "Cytokininy pat\u0159\u00ED do skupiny fytohormon\u016F1. Struktur\u00E1ln\u011B vych\u00E1z\u00ED tyto l\u00E1tky z adeninu substituovan\u00E9ho na exocyklick\u00E9 aminoskupin\u011B v poloze N-6. P\u0159irozen\u011B se vyskytuj\u00EDc\u00ED cytokininy existuj\u00ED ve form\u011B baz\u00ED, N-glykosid\u016F, O-glukosid\u016F a ribotid\u016F. U rostlin reguluj\u00ED celou \u0159adu d\u016Fle\u017Eit\u00FDch fyziologick\u00FDch proces\u016F (stimulace bun\u011B\u010Dn\u00E9ho d\u011Blen\u00ED, zpomalen\u00ED st\u00E1rnut\u00ED atd.). Jednou z nej\u00FA\u010Dinn\u011Bj\u0161\u00EDch l\u00E1tek z t\u00E9to skupiny je 6-benzylaminopurin.N\u011Bkter\u00E9 jeho syntetick\u00E9 deriv\u00E1ty (trisubstituovan\u00E9 puriny olomoucin, bohemin, roskovitin, purvalanol A) jsou zn\u00E1my jako specifick\u00E9 inhibitory proteinkinas cdk (cyklin-dependentn\u00ED kinasa). Cyklin-dependentn\u00ED kinasy jsou zodpov\u011Bdn\u00E9 za fosforylaci protein\u016F v bun\u011B\u010Dn\u00E9m cyklu a jejich inhibice m\u016F\u017Ee v\u00E9st a\u017E k apopt\u00F3ze2,3. Slou\u010Deniny purinov\u00E9ho charakteru jsou tak potencion\u00E1ln\u00EDmi protin\u00E1dorov\u00FDmi l\u00E1tkami. U jin\u00E9ho synteticky p\u0159ipraven\u00E9ho deriv\u00E1tu benzylaminopurinu, 6-(2-hydroxy-3-methoxybenzylamino)purin-9-\u00DF-ribosidu, (2-OH-3-OCH3-BAPR), byla prok\u00E1z\u00E1na vysok\u00E1 cytotoxicita proti CEM a HL"@cs .