. "Strnad, Miroslav" . "513" . "\u0158ada komplexn\u00EDch vnitrobun\u011B\u010Dn\u00FDch proces\u016F, jak\u00FDmi jsou nap\u0159. bun\u011B\u010Dn\u00FD cyklus, diferenciace, transkripce \u010Di apopt\u00F3za, je regulov\u00E1na enzymy ze skupiny cyklin-dependentn\u00ED kinas (CDK). Intenz\u00EDvn\u00ED v\u00FDzkum a v\u00FDvoj b\u011Bhem posledn\u00EDho desetilet\u00ED, nastartovan\u00FD objevem olomoucinu1, vedl k identifikaci a charakterizaci velk\u00E9ho mno\u017Estv\u00ED specifick\u00FDch inhibitor\u016F CDK, kter\u00E9 jsou schopny tyto procesy v bu\u0148k\u00E1ch ovliv\u0148ovat 2-4. Z\u00E1rove\u0148 se inhibitory CDK staly novou potenci\u00E1ln\u00ED generac\u00ED l\u00E9\u010Div c\u00EDlen\u00FDch zejm\u00E9na proti n\u00E1dorov\u00FDm onemocn\u011Bn\u00EDm, je\u017E \u00FAzce souvisej\u00ED s poruchami vnitrobun\u011B\u010Dn\u00FDch sign\u00E1ln\u00EDch drah reguluj\u00EDc\u00EDch r\u016Fst, d\u011Blen\u00ED a diferenciaci bun\u011Bk 3,4.Rutinn\u00EDm screeningem chemick\u00FDch knihoven jsme identifikovali 4-arylazo-3,5-diamino-pyrazoly jako nov\u00E9 inhibitory cyklin-dependentn\u00EDch kinas CDK1 a CDK2. Anal\u00FDza z\u00E1kladn\u00EDch vztah\u016F mezi strukturou nov\u00FDch inhibitor\u016F a jejich biologickou aktivitou nazna\u010Dila zp\u016Fsoby jejich dal\u0161\u00EDch modifikac\u00ED vzhledem ke zv\u00FD\u0161en\u00ED \u00FA\u010Dinnosti. Kinetick\u00E1 m\u011B\u0159en\u00ED prok\u00E1zala, \u017Ee 4-arylazo-3,5-diamino-pyrazol"@cs . "98" . "Rol\u010D\u00EDk, Jakub" . . "576527" . . "[4AD24CDB85EC]" . . . "\u0158ada komplexn\u00EDch vnitrobun\u011B\u010Dn\u00FDch proces\u016F, jak\u00FDmi jsou nap\u0159. bun\u011B\u010Dn\u00FD cyklus, diferenciace, transkripce \u010Di apopt\u00F3za, je regulov\u00E1na enzymy ze skupiny cyklin-dependentn\u00ED kinas (CDK). Intenz\u00EDvn\u00ED v\u00FDzkum a v\u00FDvoj b\u011Bhem posledn\u00EDho desetilet\u00ED, nastartovan\u00FD objevem olomoucinu1, vedl k identifikaci a charakterizaci velk\u00E9ho mno\u017Estv\u00ED specifick\u00FDch inhibitor\u016F CDK, kter\u00E9 jsou schopny tyto procesy v bu\u0148k\u00E1ch ovliv\u0148ovat 2-4. Z\u00E1rove\u0148 se inhibitory CDK staly novou potenci\u00E1ln\u00ED generac\u00ED l\u00E9\u010Div c\u00EDlen\u00FDch zejm\u00E9na proti n\u00E1dorov\u00FDm onemocn\u011Bn\u00EDm, je\u017E \u00FAzce souvisej\u00ED s poruchami vnitrobun\u011B\u010Dn\u00FDch sign\u00E1ln\u00EDch drah reguluj\u00EDc\u00EDch r\u016Fst, d\u011Blen\u00ED a diferenciaci bun\u011Bk 3,4.Rutinn\u00EDm screeningem chemick\u00FDch knihoven jsme identifikovali 4-arylazo-3,5-diamino-pyrazoly jako nov\u00E9 inhibitory cyklin-dependentn\u00EDch kinas CDK1 a CDK2. Anal\u00FDza z\u00E1kladn\u00EDch vztah\u016F mezi strukturou nov\u00FDch inhibitor\u016F a jejich biologickou aktivitou nazna\u010Dila zp\u016Fsoby jejich dal\u0161\u00EDch modifikac\u00ED vzhledem ke zv\u00FD\u0161en\u00ED \u00FA\u010Dinnosti. Kinetick\u00E1 m\u011B\u0159en\u00ED prok\u00E1zala, \u017Ee 4-arylazo-3,5-diamino-pyrazol" . "8" . "Nov\u00E1 skupina inhibitor\u016F cyklin-dependentn\u00EDch kinas: 4-arylazo-3,5-diaminopyrazoly"@cs . "0009-2770" . . . "Z(MSM 153100008)" . . . . "Slouka, Jan" . . "CZ - \u010Cesk\u00E1 republika" . . "New group of cyclin-dependent kinase inhibitors: 4-arylazo-3,5-diaminopyrazoles"@en . "RIV/61989592:15310/04:00002151!RIV/2005/MSM/153105/N" . . "Nov\u00E1 skupina inhibitor\u016F cyklin-dependentn\u00EDch kinas: 4-arylazo-3,5-diaminopyrazoly" . "New group of cyclin-dependent kinase inhibitors: 4-arylazo-3,5-diaminopyrazoles"@en . . . "L\u00E1tr, Ale\u0161" . "CDK;inhibitor;anticancer drug"@en . . . "Chemick\u00E9 listy" . "Many intracellular processes, e.g. cell cycle, differentiation, transcription or apoptosis, is regulated by cyclin-dependent kinases (CDK). Intensive research during last decade, initiated with the discovery of olomoucine, led to identification of many specific CDK inhibitors with cellular activity. Routine screening of chemical libraries has identified 4-arylazo-3,5-diamminopyrazoles as new inhibitors of CDK1 and CDK2."@en . "Nov\u00E1 skupina inhibitor\u016F cyklin-dependentn\u00EDch kinas: 4-arylazo-3,5-diaminopyrazoly" . "Kry\u0161tof, Vladim\u00EDr" . . . "Canka\u0159, Petr" . "RIV/61989592:15310/04:00002151" . . "15310" . "Fry\u0161ov\u00E1 - Wiedermanov\u00E1, Iveta" . "8"^^ . . "Nov\u00E1 skupina inhibitor\u016F cyklin-dependentn\u00EDch kinas: 4-arylazo-3,5-diaminopyrazoly"@cs . "7"^^ . "Otyepka, Michal" . "822"^^ .