"3"^^ . "Florida" . "Recently, a deregulation of cyclin-dependent kinases (CDKs) has been proved in human primary tumors and in tumor cell lines. The discovery evoked a strong interest in inhibitors of CDKs that could play a role in the therapy of cancers. Series of 2-, 6-, 8-, 9-tetrasubstituted purines, 3-, 7-disubstituted pyrazolo 4,3-d pyrimidines, and 2-, 6-, 9-trisubstituted 1,2,3-triazolo 4,5-d pyrimidines (8-azapurines), which specifically inhibits some CDKs at micromolar concentrations have been developed.. The compounds display (1) an enhanced inhibitory activity toward CDK1/2, or (2) a higher selectivity for some CDKs, or (3) an increased antimitotic activity at the G1/S and G2/M points of the cell cycle, and finally (4) stronger and more selective antitumor effects. Hence they can be used as antimitotic drugs, in particular, in chemotherapy of cancer, therapy of psoriasis and parasitoses as those caused by fungi or protists, treatment of Alzheimer\u00B4s disease or as antineurodegenerative drugs."@en . . "Nov\u00E9 heterocyklick\u00E9 slou\u010Deniny se siln\u00FDmi CDK-inhibi\u010Dn\u00EDmi a protin\u00E1dorov\u00FDmi vlastnostmi."@cs . "New heterocyclic compounds with strong CDK inhibitory and anticancer properties."@en . "Nov\u00E9 heterocyklick\u00E9 slou\u010Deniny se siln\u00FDmi CDK-inhibi\u010Dn\u00EDmi a protin\u00E1dorov\u00FDmi vlastnostmi."@cs . . . "American Association for Cancer Research" . . "15310" . "Lenobel, Ren\u00E9" . . . "New heterocyclic compounds with strong CDK inhibitory and anticancer properties." . . "Strnad, Miroslav" . . "CDK;purine inhibitors;cell cycle"@en . . "Kry\u0161tof, Vladim\u00EDr" . "Havl\u00ED\u010Dek, Libor" . "RIV/61989592:15310/04:00002120" . "Deregulace cyklin-dependentn\u00EDch (CDK) kinas \u00FAzce souvis\u00ED se vznikem r\u016Fstem n\u00E1dor\u016F. Tato skute\u010Dnost vyvolala z\u00E1jem o specifick\u00E9 inhibitory CDK pou\u017Eiteln\u00E9 v terapii n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED. Vyvinuli jsme s\u00E9rie specifick\u00FDch inhibitor\u016F CDK na b\u00E1zi 2,6,8,9-tetrasubstituovan\u00FDch purin\u016F, 3,7-disubstituovan\u00FDch pyrazolo[4,3-d]pyrimidin\u016F a 2,6,9-trisubstituovan\u00FDch 1,2,3-triazolo[4,5-d]pyrimidin\u016F (8-azapurin\u016F). Tyto slou\u010Deniny vykazuj\u00ED silnou inhibi\u010Dn\u00ED aktivitu na CDK1/2, vy\u0161\u0161\u00ED selektivitu pro CDK, silnou antimitotickou aktivitu a pozoruhodn\u00E9 protin\u00E1dorov\u00E9 \u00FA\u010Dinky. Mohou proto b\u00FDt pou\u017Eity jako antimitotick\u00E9 l\u00E1tky, zvl\u00E1\u0161t\u011B pak jako protin\u00E1dorov\u00E1 chemoterapeutika, l\u00E9\u010Diva pro prosiasu, parasitosy, Alzeimerovy choroby a jin\u00FDch antineurodegenerativn\u00EDch poruch."@cs . "[7F59BE0FBBC5]" . "RIV/61989592:15310/04:00002120!RIV/2005/MSM/153105/N" . "576090" . . "225"^^ . . "Recently, a deregulation of cyclin-dependent kinases (CDKs) has been proved in human primary tumors and in tumor cell lines. The discovery evoked a strong interest in inhibitors of CDKs that could play a role in the therapy of cancers. Series of 2-, 6-, 8-, 9-tetrasubstituted purines, 3-, 7-disubstituted pyrazolo 4,3-d pyrimidines, and 2-, 6-, 9-trisubstituted 1,2,3-triazolo 4,5-d pyrimidines (8-azapurines), which specifically inhibits some CDKs at micromolar concentrations have been developed.. The compounds display (1) an enhanced inhibitory activity toward CDK1/2, or (2) a higher selectivity for some CDKs, or (3) an increased antimitotic activity at the G1/S and G2/M points of the cell cycle, and finally (4) stronger and more selective antitumor effects. Hence they can be used as antimitotic drugs, in particular, in chemotherapy of cancer, therapy of psoriasis and parasitoses as those caused by fungi or protists, treatment of Alzheimer\u00B4s disease or as antineurodegenerative drugs." . "Cell Cycle and Cancer: Pathways and Therapies" . "Z(MSM 153100008)" . . "B6" . "New heterocyclic compounds with strong CDK inhibitory and anticancer properties."@en . "4"^^ . . . . . . "New heterocyclic compounds with strong CDK inhibitory and anticancer properties." .