. "Hanu\u0161, Jan" . . "91"^^ . . . . "Berneman, Z." . "5"^^ . "Inhibition of cyclin-dependent kinases (CDK's), the most promising drug target of the new era, became one of the most suitable methods for stopping the division of cancer cells. Several families of low molecular weight compounds were identified as specific CDK inhibitors, sharing a common ATP competing mechanism [1-2]. Some of them have already undergone in vivo efficacy studies, preclinical and clinical evaluation, and thus confirmed the selected CDK's as a proper target for development of new anticancer drugs. Up to now the advancement of purine CDK inhibitors has been based mainly on modifications of substituents at positions 2, 6 and 9, respectively [1-3]. To extend the inhibitor-CDK mutual interactions in a different manner, we introduced anotherside chain at C-8 of purine and rearranged the purine heteroatoms, respectively." . "Strnad, Miroslav" . "Centro Nacional de Investigaciones Oncol\u00F3gicas Carlos III." . . . "11"^^ . "624286" . "Purine based inhibitors of cyclin-dependent kinases" . . . "Inhibition of cyclin-dependent kinases (CDK's), the most promising drug target of the new era, became one of the most suitable methods for stopping the division of cancer cells. Several families of low molecular weight compounds were identified as specific CDK inhibitors, sharing a common ATP competing mechanism [1-2]. Some of them have already undergone in vivo efficacy studies, preclinical and clinical evaluation, and thus confirmed the selected CDK's as a proper target for development of new anticancer drugs. Up to now the advancement of purine CDK inhibitors has been based mainly on modifications of substituents at positions 2, 6 and 9, respectively [1-3]. To extend the inhibitor-CDK mutual interactions in a different manner, we introduced anotherside chain at C-8 of purine and rearranged the purine heteroatoms, respectively."@en . . "[33962E260322]" . . "Moravec, J." . . "RIV/61989592:15310/03:00001572!RIV/2004/GA0/153104/N" . "Purine based inhibitors of cyclin-dependent kinases"@en . "Otyepka, Michal" . "Moravcov\u00E1, D." . "Fuksov\u00E1, K." . "15310" . "TARGETED SEARCH FOR ANTICANCER DRUGS" . . "P(GA301/02/0475), P(GA303/02/0875)" . . . "Vermeulen, K." . "Purine, inhibitors, CDK"@en . "Purine based inhibitors of cyclin-dependent kinases" . "Madrid" . "Kry\u0161tof, Vladim\u00EDr" . . . "Madrid" . "Lenobel, Ren\u00E9" . . "Purine based inhibitors of cyclin-dependent kinases"@en . "0"^^ . "RIV/61989592:15310/03:00001572" . . "0"^^ . . "11" . . "Havl\u00ED\u010Dek, L." .