"Z(MSM 153100013)" . . . . "3-quinuclidinol; quaternary ammonium salt; capillary electrophoresis; electrospray ionization; mass spectrometry; capillary electrophoresis/mass spectrometry"@en . . . . . "12" . "640097" . "A method based on the coupling of capillary electrophoresis with mass spectrometry (CE/MS) was developed for the monitoring of 3-quinuclidinol and its four N-alkyl derivatives (methyl, ethyl, propyl and isopropyl derivatives). A fragmentation study (collision-induced dissociation of ions in an ion trap) and optimization of the ion optics set-up for CE/MS experiments using direct infusion of a methanolic solution of the standards into the mass spectrometer were carried out in advance. Molecular ions ofall quaternary compounds and the quasi-molecular ion [M + H](+) of free 3-quinuclidinol prevail in the mass spectra. In the MS/MS of propyl and isopropyl derivatives, the elimination of the alkyl chain dominates, leading to the ion at m/z 128. The fragm entation of the other compounds is more complex. Previous CE separation of the mixture of isobaric propyl and isopropyl derivatives is necessary for their unambiguous identification. A 10 mm ammonium acetate buffer (pH 4.0) is the optimum running electro" . "Lemr, Karel" . . . . "37" . "Capillary electrophoresis/mass spectrometry: a promising tool for the control of some physiologically hazardous compounds. I - Derivatives of 3-quinuclidinol"@en . . . "Capillary electrophoresis/mass spectrometry: a promising tool for the control of some physiologically hazardous compounds. I - Derivatives of 3-quinuclidinol"@en . "St\u00FDskala, Jakub" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . . "\u0160ev\u010D\u00EDk, Juraj" . "Capillary electrophoresis/mass spectrometry: a promising tool for the control of some physiologically hazardous compounds. I - Derivatives of 3-quinuclidinol" . "[1B80F0B84FD8]" . . "Capillary electrophoresis/mass spectrometry: a promising tool for the control of some physiologically hazardous compounds. I - Derivatives of 3-quinuclidinol" . "15310" . "Journal of Mass Spectrometry" . . . "Bart\u00E1k, Petr" . . "Wiedermanov\u00E1, Iveta" . "RIV/61989592:15310/02:00001413!RIV/2003/MSM/153103/N" . "Bedn\u00E1\u0159, Petr" . "8"^^ . . . "1076-5174" . "8"^^ . "1213-1218" . . . . "Hlav\u00E1\u010D, Jan" . . "Str\u00E1nsk\u00FD, Zden\u011Bk" . "RIV/61989592:15310/02:00001413" . . "6"^^ . "0"^^ . "A method based on the coupling of capillary electrophoresis with mass spectrometry (CE/MS) was developed for the monitoring of 3-quinuclidinol and its four N-alkyl derivatives (methyl, ethyl, propyl and isopropyl derivatives). A fragmentation study (collision-induced dissociation of ions in an ion trap) and optimization of the ion optics set-up for CE/MS experiments using direct infusion of a methanolic solution of the standards into the mass spectrometer were carried out in advance. Molecular ions ofall quaternary compounds and the quasi-molecular ion [M + H](+) of free 3-quinuclidinol prevail in the mass spectra. In the MS/MS of propyl and isopropyl derivatives, the elimination of the alkyl chain dominates, leading to the ion at m/z 128. The fragm entation of the other compounds is more complex. Previous CE separation of the mixture of isobaric propyl and isopropyl derivatives is necessary for their unambiguous identification. A 10 mm ammonium acetate buffer (pH 4.0) is the optimum running electro"@en . "0"^^ . .