"[E3B9C6649FB2]" . . . . . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Grepl, M." . . "16" . "I, P(ED0030/01/01), P(EE2.3.20.0009), P(EE2.4.31.0130)" . . "Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues" . "15110" . "F\u00FCl\u00F6pov\u00E1, Veronika" . "Popa, Igor" . . "Mcmaster, Claire Suzanne" . . . . "2156-8952" . "Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues"@en . "5" . "Cyclative cleavage; Solid-phase synthesis; 2-Nitrobenzenesulfonylchlorides; Fmoc-amino acids; Cyclic guanidines; Anagrelide analogues"@en . "RIV/61989592:15110/14:33151916!RIV15-MSM-15110___" . . "ACS Combinatorial Science" . "4"^^ . "Soural, Miroslav" . . "RIV/61989592:15110/14:33151916" . . "5"^^ . "45894" . "Simple solid-phase synthesis of 3,10-dihydro-2H-benzo[e]imidazothiadiazin-2-one 5,5-dioxides is described, with Fmoc-?-amino acids and 2-nitrobenzenesulfonylchlorides (2-NosCls) being the key building blocks. Fmoc-?-amino acids were immobilized on Wang resin and transformed to the corresponding 2-nitrobenzenesulfonamides in two steps. After reduction of the nitro group, Fmoc-thioureas were synthesized followed by cyclization of the 1,2,4-benzothiadiazine-1,1-dioxide scaffold with diisopropylcarbodiimide (DIC). Cleavage of the Fmoc protecting group followed by spontaneous cyclative cleavage gave the target products in excellent crude purity." . . . "Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues" . . . . "Simple solid-phase synthesis of 3,10-dihydro-2H-benzo[e]imidazothiadiazin-2-one 5,5-dioxides is described, with Fmoc-?-amino acids and 2-nitrobenzenesulfonylchlorides (2-NosCls) being the key building blocks. Fmoc-?-amino acids were immobilized on Wang resin and transformed to the corresponding 2-nitrobenzenesulfonamides in two steps. After reduction of the nitro group, Fmoc-thioureas were synthesized followed by cyclization of the 1,2,4-benzothiadiazine-1,1-dioxide scaffold with diisopropylcarbodiimide (DIC). Cleavage of the Fmoc protecting group followed by spontaneous cyclative cleavage gave the target products in excellent crude purity."@en . "3"^^ . . "Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues"@en . "Mcmaster, Claire Suzanne" .