"10.1210/en.2014-1027" . . "Schov\u00E1nek, Jan" . . "RIV/61989592:15110/14:33150458!RIV15-MSM-15110___" . "Lovastatin showed anti-proliferative effects in vitro and led to significantly smaller tumor sizes in vivo compared to vehicle-treatment. 13cRA promoted tumor cell growth in vitro and led to significantly larger viable tumor mass and significantly faster increase of viable tumor mass in vivo over time compared to vehicle- and lovastatin-treatment. However, when combined with lovastatin, 13cRA enhanced the anti-proliferative effect of lovastatin in vivo. The combination-treated mice showed slowest tumor growth of all groups with significantly slower tumor growth compared to the vehicle-treated mice and significantly smaller tumor sizes. Moreover, the combination-treated group displayed the smallest size of viable tumor mass and the slowest increase in viable tumor mass over time of all groups, with a significant difference compared to the vehicle- and 13cRA-treated group. The combination-treated tumors showed highest extent of necrosis, lowest median microvessel density (MVD) and highest expression of alpha-smooth muscle actin. The combination of highe MVD and low alpha-SMA is a predictor of poor prognosis in other tumor entities."@en . . "Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice"@en . "15110" . "RIV/61989592:15110/14:33150458" . . "1"^^ . "Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice"@en . "Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice" . . . "0013-7227" . "14"^^ . "Endocrinology" . "7801" . . "Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice" . "[8852D5FF086A]" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "pheochromocytoma; 13-cis retinoic acid; lovastatin"@en . . . "7" . "Tayem, Yasin" . . "155" . . "14"^^ . . "Nolting, Svenja" . . "Giubellino, Alessio" . "Lovastatin showed anti-proliferative effects in vitro and led to significantly smaller tumor sizes in vivo compared to vehicle-treatment. 13cRA promoted tumor cell growth in vitro and led to significantly larger viable tumor mass and significantly faster increase of viable tumor mass in vivo over time compared to vehicle- and lovastatin-treatment. However, when combined with lovastatin, 13cRA enhanced the anti-proliferative effect of lovastatin in vivo. The combination-treated mice showed slowest tumor growth of all groups with significantly slower tumor growth compared to the vehicle-treated mice and significantly smaller tumor sizes. Moreover, the combination-treated group displayed the smallest size of viable tumor mass and the slowest increase in viable tumor mass over time of all groups, with a significant difference compared to the vehicle- and 13cRA-treated group. The combination-treated tumors showed highest extent of necrosis, lowest median microvessel density (MVD) and highest expression of alpha-smooth muscle actin. The combination of highe MVD and low alpha-SMA is a predictor of poor prognosis in other tumor entities." . "I" . .