. "Barbara P, De Santa" . . "Gastrointestinal stromal tumour: From the clinic to the molecules" . "http://nobleresearch.org/Journals/JCRT/Volume2/2052-4994-2014-8.aspx" . "10.14312/2052-4994.2014-8" . . "Gastrointestinal stromal tumour: From the clinic to the molecules" . . "Hapkov\u00E1, Ilona" . "Gastrointestinal stromal tumour: From the clinic to the molecules"@en . . "GastroIntestional stromal tumours (GISTs), the most frequent sarcoma in the gastro-intestinal (GI) tract, are highly resistant to conventional chemotherapy and radiotherapy. These tumours have activating mutations in two closely related genes, KIT (75-80%) or/and PDGFRA (5-10%). Targeting these mutated activated proteins with imatinib mesylate has proven efficient in the treatment of GISTs. The median survival after diagnosis of GIST increased from 1.5 to 4.8 years with imatinib treatment. However, resistance to imatinib eventually develops and new-targeted therapies are needed. This paper reviews the medical, clinical and pathological aspects of GISTs based on latest research in human cell lines and animal models." . "imatinib mesylate; activating mutation; platelet-derived growth factor receptor alpha; KIT; smooth muscle cells; interstitial cells of cajal; gastrointestinal stromal tumours"@en . . "2052-4994" . "3" . "GastroIntestional stromal tumours (GISTs), the most frequent sarcoma in the gastro-intestinal (GI) tract, are highly resistant to conventional chemotherapy and radiotherapy. These tumours have activating mutations in two closely related genes, KIT (75-80%) or/and PDGFRA (5-10%). Targeting these mutated activated proteins with imatinib mesylate has proven efficient in the treatment of GISTs. The median survival after diagnosis of GIST increased from 1.5 to 4.8 years with imatinib treatment. However, resistance to imatinib eventually develops and new-targeted therapies are needed. This paper reviews the medical, clinical and pathological aspects of GISTs based on latest research in human cell lines and animal models."@en . . "2" . "Florence, Bernex" . . "17950" . "[26F38B3AD0B9]" . . "RIV/61989592:15110/14:33148908!RIV15-MSM-15110___" . "Journal of Cancer Research & Therapy" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "14"^^ . . . "RIV/61989592:15110/14:33148908" . . . "Gastrointestinal stromal tumour: From the clinic to the molecules"@en . "15110" . . . "4"^^ . . . "Vesel\u00FD, Jaroslav" . . "2"^^ . . "I" .