"I" . . "RIV/61989592:15110/13:33146890!RIV14-MSM-15110___" . "1801-1209" . "CZ - \u010Cesk\u00E1 republika" . "Agomelatin je po dlouh\u00E9 dob\u011B prvn\u00ED antidepresivum s nov\u00FDm mechanismem \u00FA\u010Dinku. Je agonistou melatoninovych receptor\u016F MT1 a MT2, antagonistou receptor\u016F 5HT2C a jeho antidepresivn\u00ED \u00FA\u010Dinek je z\u0159ejm\u011B zprost\u0159edkov\u00E1n resynchronizac\u00ED cirkadi\u00E1nn\u00EDch rytm\u016F. P\u016Fsob\u00ED i anxiolyticky a m\u00E1 sv\u00E9 m\u00EDsto v l\u00E9\u010Db\u011B deprese a generalizovan\u00E9 \u00FAzkostn\u00E9 poruchy. Agomelatin m\u00E1 rychl\u00FD n\u00E1stup \u00FA\u010Dinku a je velmi dob\u0159e sn\u00E1\u0161en. Nezp\u016Fsobuje poruchu sexu\u00E1ln\u00ED funkce a nevyvol\u00E1v\u00E1 p\u0159\u00EDznaky z vysazen\u00ED." . . "Agomelatine is a long time of the first antidepressant with a new mechanism of action. Agonist is melatonin MT1 and MT2 receptors, 5HT2C receptor antagonist and the antidepressant effect is probably mediated by resynchronizing circadian rhythms. It acts as an anxiolytic and has a place in the treatment of depression and generalized anxiety disorders. Agomelatine has a rapid onset of action and is very well tolerated. It does not cause sexual dysfunction and does not withdrawal symptoms."@en . . "L\u00E9\u010Dba deprese agomelatinem" . "Agomelatin je po dlouh\u00E9 dob\u011B prvn\u00ED antidepresivum s nov\u00FDm mechanismem \u00FA\u010Dinku. Je agonistou melatoninovych receptor\u016F MT1 a MT2, antagonistou receptor\u016F 5HT2C a jeho antidepresivn\u00ED \u00FA\u010Dinek je z\u0159ejm\u011B zprost\u0159edkov\u00E1n resynchronizac\u00ED cirkadi\u00E1nn\u00EDch rytm\u016F. P\u016Fsob\u00ED i anxiolyticky a m\u00E1 sv\u00E9 m\u00EDsto v l\u00E9\u010Db\u011B deprese a generalizovan\u00E9 \u00FAzkostn\u00E9 poruchy. Agomelatin m\u00E1 rychl\u00FD n\u00E1stup \u00FA\u010Dinku a je velmi dob\u0159e sn\u00E1\u0161en. Nezp\u016Fsobuje poruchu sexu\u00E1ln\u00ED funkce a nevyvol\u00E1v\u00E1 p\u0159\u00EDznaky z vysazen\u00ED."@cs . "antagonist; Agomelatine, antidepressant"@en . "2"^^ . . "L\u00E9\u010Dba deprese agomelatinem" . . . . "84537" . "L\u00E1talov\u00E1, Kl\u00E1ra" . "1"^^ . "Treating depression with agomelatine"@en . "[40A6904EF5DE]" . . "L\u00E9\u010Dba deprese agomelatinem"@cs . "1"^^ . "Farmakoterapie: diagetologie - alergologie - pneumologie - revmatologie" . . . "15110" . . "RIV/61989592:15110/13:33146890" . . "2013" . "Treating depression with agomelatine"@en . "L\u00E9\u010Dba deprese agomelatinem"@cs . . "6" . . .