"Parkinsonova nemoc je st\u00E1le popisov\u00E1na jako relativn\u011B homogenn\u00ED nozologick\u00E1 jednotka, charakterizovan\u00E1 z\u00E1kladn\u00ED tetr\u00E1dou p\u0159\u00EDznak\u016F - bradykinez\u00ED, rigiditou, tremorem a postur\u00E1ln\u00ED nestabilitou - s m\u011Bnlivou p\u0159\u00EDtomnost\u00ED a intenzitou dal\u0161\u00EDch symptom\u016F motorick\u00FDch a non-motorick\u00FDch (kognitivn\u00EDch, behavior\u00E1ln\u00EDch, vegetativn\u00EDch apod.), vznikaj\u00EDc\u00EDch na podklad\u011B rozvoje mozkov\u00E9 tzv. alfa-synukleinopatie. Je\u0161t\u011B ned\u00E1vno se zd\u00E1lo, \u017Ee jde o klinickou entitu, kde lze diagn\u00F3zu pom\u011Brn\u011B snasno stanovit na z\u00E1klad\u011B univerz\u00E1ln\u011B pou\u017E\u00EDvan\u00FDch tzv. United Kingdom Parkinson's Disease Brain Bank krit\u00E9ri\u00ED, vytvo\u0159en\u00FDch p\u0159ed 20 lety na z\u00E1klad\u011B retrospektivn\u00ED klinicko-patologick\u00E9 studie. V posledn\u00EDch 10 letech ale do\u0161lo (d\u00EDky intenzivn\u00EDmu v\u00FDzkumu) k v\u00FDznamn\u00E9mu posunu v ch\u00E1p\u00E1n\u00ED parkinzonizmu a Parkinsonovy nemoci. Arbitr\u00E1rn\u011B byla diferencov\u00E1na demence s Lewyho t\u011Bl\u00EDsky a Parkinsonova nemoc s demenc\u00ED. K dosud existuj\u00EDc\u00EDm zn\u00E1m\u00FDm famili\u00E1rn\u00EDm form\u00E1m Parkinsonovy nemoci se za\u010D\u00E1tkem v mlad\u00E9m v\u011Bku bylo p\u0159id\u00E1no n\u011Bkolik dal\u0161\u00EDch geneticky v\u00E1zan\u00FDch forem Parkinsonovy nemoci, kter\u00E9 se sv\u00FDm fenotypem, za\u010D\u00E1tkem a klinick\u00FDm pr\u016Fb\u011Bhem od tzv. klasick\u00E9 %22sporadick\u00E9%22 Parkinsonovy nemoci prakticky neli\u0161\u00ED. Ozna\u010Den\u00ED Parkinsonova nemoc by m\u011Blo b\u00FDt u\u017E\u00EDv\u00E1no vlastn\u011B jen pro tzv. sporadickou Parkinsonovu nemoc, p\u0159i\u010Dem\u017E k (relativn\u011B) jist\u00E9 \u010Di spolehliv\u00E9 diagn\u00F3ze t\u00E9to formy nemoci in vivo nejsou krit\u00E9ria UK-PDBB ide\u00E1ln\u00ED; term\u00EDn Neurodegenerativn\u00ED perkinzonizmus by patrn\u011B sou\u010Dasnou \u00FArove\u0148 diagnostick\u00E9 jistoty reflektoval l\u00E9pe."@cs . "The Changing Face of Parkinsonian Neurodegeneration"@en . "Parkinson's disease continues to be described as a relatively homogenous nosological entity, characterised by the presence of four cardinal signs bradykinesia, rigidity, tremor and postural instability with a variable presence of other motor and non-motor symptoms (cognitive, behavioral, vegetative etc.); its pathological basis being the continuous progression of brain alpha-synucleinopathy. It seemed that this clinical entity might be relatively easily diagnosed using the United Kingdom Parkinson's Disease Brain Bank (UK-PDBB) clinical diagnostic criteria that are based on the results of a retrospective clinical and pathological study. However, substantial opinion shift occurred as a result of the recent intensive field research. A distinction has arbitrarily been made between Dementia with Lewy bodies and Parkinson's disease dementia. Several next mutations (PARK10 PARK13, PARK16 PARK18) encoding the manifestation of %22sporadic%22, late-onset and typical Parkinson's disease have been added to the existing spectrum of familiar Parkinson's disease. Therefore, the term %22Parkinson's disease%22 should be used for the %22sporadic%22 form of the disease only. However, for the %22definite%22 or %22highly probable%22 level of diagnostic accuracy, the UK-PDBB criteria are less useful. The term %22neurodegenerative Parkinsonism%22 would probably better reflect current level of diagnostic certainty referring to Parkinson's disease."@en . "Bare\u0161, Martin" . "9"^^ . "The Changing Face of Parkinsonian Neurodegeneration"@en . "1" . "Nestra\u0161il, Igor" . "100287" . "CZ - \u010Cesk\u00E1 republika" . "RIV/61989592:15110/13:33145087!RIV14-MZ0-15110___" . . "[FC4066829E0D]" . "000314553500003" . "Ka\u0148ovsk\u00FD, Petr" . . . . "Prom\u011Bnliv\u00E1 tv\u00E1\u0159 parkinsonsk\u00E9 neurodegenerace" . "1"^^ . . "Prom\u011Bnliv\u00E1 tv\u00E1\u0159 parkinsonsk\u00E9 neurodegenerace" . . . "Prom\u011Bnliv\u00E1 tv\u00E1\u0159 parkinsonsk\u00E9 neurodegenerace"@cs . "Parkinson's Disease"@en . "Prom\u011Bnliv\u00E1 tv\u00E1\u0159 parkinsonsk\u00E9 neurodegenerace"@cs . "Parkinsonova nemoc je st\u00E1le popisov\u00E1na jako relativn\u011B homogenn\u00ED nozologick\u00E1 jednotka, charakterizovan\u00E1 z\u00E1kladn\u00ED tetr\u00E1dou p\u0159\u00EDznak\u016F - bradykinez\u00ED, rigiditou, tremorem a postur\u00E1ln\u00ED nestabilitou - s m\u011Bnlivou p\u0159\u00EDtomnost\u00ED a intenzitou dal\u0161\u00EDch symptom\u016F motorick\u00FDch a non-motorick\u00FDch (kognitivn\u00EDch, behavior\u00E1ln\u00EDch, vegetativn\u00EDch apod.), vznikaj\u00EDc\u00EDch na podklad\u011B rozvoje mozkov\u00E9 tzv. alfa-synukleinopatie. Je\u0161t\u011B ned\u00E1vno se zd\u00E1lo, \u017Ee jde o klinickou entitu, kde lze diagn\u00F3zu pom\u011Brn\u011B snasno stanovit na z\u00E1klad\u011B univerz\u00E1ln\u011B pou\u017E\u00EDvan\u00FDch tzv. United Kingdom Parkinson's Disease Brain Bank krit\u00E9ri\u00ED, vytvo\u0159en\u00FDch p\u0159ed 20 lety na z\u00E1klad\u011B retrospektivn\u00ED klinicko-patologick\u00E9 studie. V posledn\u00EDch 10 letech ale do\u0161lo (d\u00EDky intenzivn\u00EDmu v\u00FDzkumu) k v\u00FDznamn\u00E9mu posunu v ch\u00E1p\u00E1n\u00ED parkinzonizmu a Parkinsonovy nemoci. Arbitr\u00E1rn\u011B byla diferencov\u00E1na demence s Lewyho t\u011Bl\u00EDsky a Parkinsonova nemoc s demenc\u00ED. K dosud existuj\u00EDc\u00EDm zn\u00E1m\u00FDm famili\u00E1rn\u00EDm form\u00E1m Parkinsonovy nemoci se za\u010D\u00E1tkem v mlad\u00E9m v\u011Bku bylo p\u0159id\u00E1no n\u011Bkolik dal\u0161\u00EDch geneticky v\u00E1zan\u00FDch forem Parkinsonovy nemoci, kter\u00E9 se sv\u00FDm fenotypem, za\u010D\u00E1tkem a klinick\u00FDm pr\u016Fb\u011Bhem od tzv. klasick\u00E9 %22sporadick\u00E9%22 Parkinsonovy nemoci prakticky neli\u0161\u00ED. Ozna\u010Den\u00ED Parkinsonova nemoc by m\u011Blo b\u00FDt u\u017E\u00EDv\u00E1no vlastn\u011B jen pro tzv. sporadickou Parkinsonovu nemoc, p\u0159i\u010Dem\u017E k (relativn\u011B) jist\u00E9 \u010Di spolehliv\u00E9 diagn\u00F3ze t\u00E9to formy nemoci in vivo nejsou krit\u00E9ria UK-PDBB ide\u00E1ln\u00ED; term\u00EDn Neurodegenerativn\u00ED perkinzonizmus by patrn\u011B sou\u010Dasnou \u00FArove\u0148 diagnostick\u00E9 jistoty reflektoval l\u00E9pe." . . . "5"^^ . "76" . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . "15110" . "Men\u0161\u00EDkov\u00E1, Kate\u0159ina" . . . "1210-7859" . "RIV/61989592:15110/13:33145087" . "Kaiserov\u00E1, Michaela" . . . "I, P(NT12221)" . . .