"Cerebrospinal fluid examination in multiple sclerosis"@en . "1336-8621" . "15110" . "RIV/61989592:15110/12:33140053!RIV13-MSM-15110___" . . . "Sl\u00E1dkov\u00E1, Vladim\u00EDra" . . "Cerebrospinal fluid examination in multiple sclerosis"@en . . "RIV/61989592:15110/12:33140053" . "5"^^ . . "Roztrou\u0161en\u00E1 skler\u00F3za mozkom\u00ED\u0161n\u00ED (RS) je chronick\u00E9 z\u00E1n\u011Btliv\u00E9 demyelinizac\u00ED onemocn\u011Bn\u00ED CNS s prevalenc\u00ED v na\u0161ich zem\u00EDch 80-130 nemocn\u00FDch na 100 000 obyvatel. Pat\u0159\u00ED mezi autoimunitn\u00ED onemocn\u011Bn\u00ED vedouc\u00ED k demyelinizaci nervov\u00FDch vl\u00E1ken a je?jich n\u00E1sledn\u00E9 ztr\u00E1t\u011B. Podle McDonaldov\u00FDch diagnostick\u00FDch krit\u00E9ri\u00ED publikovan\u00FDch v roce 2001 a jejich revidovan\u00E9 verze z roku 2005 byly krom\u011B klinick\u00E9ho vy\u0161et\u0159en\u00ED z\u00E1kladn\u00EDmi metodami ke stanoven\u00ED diagn\u00F3zy RS anal\u00FDza mozkom\u00ED\u0161n\u00EDho moku a MR zobrazen\u00ED. P\u0159esto\u017Ee podle revize t\u011Bchto krit\u00E9ri\u00ED z roku 2010 likvorov\u00E9 vy\u0161et\u0159en\u00ED ji\u017E nen\u00ED ke stanoven\u00ED diagn\u00F3zy RS nutn\u00E9, st\u00E1le p\u0159in\u00E1\u0161\u00ED podstatn\u00E9 \u00FAdaje pot\u0159ebn\u00E9 v diferenci\u00E1ln\u011B diagnostick\u00E9 rozvaze. K z\u00E1kladn\u00EDm likvorologick\u00FDm vy\u0161et\u0159en\u00EDm pat\u0159\u00ED kvan?titativn\u00ED a kvalitativn\u00ED cytologie, z\u00E1kladn\u00ED biochemick\u00E9 vy\u0161et\u0159en\u00ED, posouzen\u00ED stavu hemato-likvorov\u00E9 bari\u00E9ry (HLB), vy\u0161et\u0159en\u00ED intratek\u00E1ln\u00ED synt\u00E9zy IgG a stanoven\u00ED po\u010Dtu oligoklon\u00E1ln\u00EDch IgG p\u00E1s\u016F (OCB). Spektrum vy\u0161et\u0159en\u00ED lze doplnit tzv. MRZ reakc\u00ED neboli stanoven\u00EDm intratek\u00E1ln\u00ED synt\u00E9zy specifick\u00FDch IgG protil\u00E1tek proti neurotropn\u00EDm vir\u016Fm (viru spalni\u010Dek, rubeola-zoster a zard\u011Bnek) a stanoven\u00EDm hladin n\u011Bkter\u00FDch z\u00E1n\u011Btliv\u00FDch \u010Di neurodegenerativn\u00EDch marker\u016F."@cs . . . "Vy\u0161et\u0159en\u00ED mozkom\u00ED\u0161n\u00EDho moku u roztrou\u0161en\u00E9 skler\u00F3zy"@cs . "2"^^ . "oligoclonal bands; intrathecal synthesis; cerebrospinal liquid; Multiple sclerosis cerebrospinal"@en . "Neurol\u00F3gia" . "Vy\u0161et\u0159en\u00ED mozkom\u00ED\u0161n\u00EDho moku u roztrou\u0161en\u00E9 skler\u00F3zy"@cs . "Vy\u0161et\u0159en\u00ED mozkom\u00ED\u0161n\u00EDho moku u roztrou\u0161en\u00E9 skler\u00F3zy" . "Ka\u0148ovsk\u00FD, Petr" . "3"^^ . . . "7" . "Vy\u0161et\u0159en\u00ED mozkom\u00ED\u0161n\u00EDho moku u roztrou\u0161en\u00E9 skler\u00F3zy" . "SK - Slovensk\u00E1 republika" . "179127" . . . . . "V" . "Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of CNS with the prevalence of 80-130 patients out of 100 000 inhabitants in our country. It belongs to autoimmune diseases leading to demyelisation of nervous fibres and their consequent loss. According to McDonald diagnostic criteria published in 2001 and their revised version from the year 2005 besides clinical examinations basic methods to make diagnosis of MS were an analysis of cerebrospinal liquid and MR imaging. Even according to the revision of these criteria from the year 2010 the liquor examination is not necessary for the establish?ing of the MS diagnosis any more, it still brings essential data needed to differential diagnostics. Quantitative and qualitative cytology, essential biochemistry examinations, assessment of the condition of heamato-liqour barrier (HLB), examination of intrathecal synthesis of IgG and determination of the number of oligoclonal IgG bands (OCB) belong to essential liquor ex?aminations. The spectrum could be supplemented by the so-called MRZ reaction or detection of intrathecal synthesis of specific IgG antibodies against neurotropic viruses (the virus of measles, rubella zoster and rubella) and by the level detection of some inflammatory or neurodegenerative markers."@en . "Mare\u0161, Jan" . . "Roztrou\u0161en\u00E1 skler\u00F3za mozkom\u00ED\u0161n\u00ED (RS) je chronick\u00E9 z\u00E1n\u011Btliv\u00E9 demyelinizac\u00ED onemocn\u011Bn\u00ED CNS s prevalenc\u00ED v na\u0161ich zem\u00EDch 80-130 nemocn\u00FDch na 100 000 obyvatel. Pat\u0159\u00ED mezi autoimunitn\u00ED onemocn\u011Bn\u00ED vedouc\u00ED k demyelinizaci nervov\u00FDch vl\u00E1ken a je?jich n\u00E1sledn\u00E9 ztr\u00E1t\u011B. Podle McDonaldov\u00FDch diagnostick\u00FDch krit\u00E9ri\u00ED publikovan\u00FDch v roce 2001 a jejich revidovan\u00E9 verze z roku 2005 byly krom\u011B klinick\u00E9ho vy\u0161et\u0159en\u00ED z\u00E1kladn\u00EDmi metodami ke stanoven\u00ED diagn\u00F3zy RS anal\u00FDza mozkom\u00ED\u0161n\u00EDho moku a MR zobrazen\u00ED. P\u0159esto\u017Ee podle revize t\u011Bchto krit\u00E9ri\u00ED z roku 2010 likvorov\u00E9 vy\u0161et\u0159en\u00ED ji\u017E nen\u00ED ke stanoven\u00ED diagn\u00F3zy RS nutn\u00E9, st\u00E1le p\u0159in\u00E1\u0161\u00ED podstatn\u00E9 \u00FAdaje pot\u0159ebn\u00E9 v diferenci\u00E1ln\u011B diagnostick\u00E9 rozvaze. K z\u00E1kladn\u00EDm likvorologick\u00FDm vy\u0161et\u0159en\u00EDm pat\u0159\u00ED kvan?titativn\u00ED a kvalitativn\u00ED cytologie, z\u00E1kladn\u00ED biochemick\u00E9 vy\u0161et\u0159en\u00ED, posouzen\u00ED stavu hemato-likvorov\u00E9 bari\u00E9ry (HLB), vy\u0161et\u0159en\u00ED intratek\u00E1ln\u00ED synt\u00E9zy IgG a stanoven\u00ED po\u010Dtu oligoklon\u00E1ln\u00EDch IgG p\u00E1s\u016F (OCB). Spektrum vy\u0161et\u0159en\u00ED lze doplnit tzv. MRZ reakc\u00ED neboli stanoven\u00EDm intratek\u00E1ln\u00ED synt\u00E9zy specifick\u00FDch IgG protil\u00E1tek proti neurotropn\u00EDm vir\u016Fm (viru spalni\u010Dek, rubeola-zoster a zard\u011Bnek) a stanoven\u00EDm hladin n\u011Bkter\u00FDch z\u00E1n\u011Btliv\u00FDch \u010Di neurodegenerativn\u00EDch marker\u016F." . . . . "[92C131C4FE9B]" . "1" .