. "10.5507/bp.2012.002" . "15110" . . "1213-8118" . "Zah\u00E1lkov\u00E1, Jana" . . "Vancomycin removal during low-flux and high-flux extended daily hemodialysis in critically ill septic patients"@en . . "Mart\u00EDnek, Arno\u0161t" . "Brozmanov\u00E1, Hana" . "156" . "[53545A6A91CF]" . "Vancomycin removal during low-flux and high-flux extended daily hemodialysis in critically ill septic patients" . "CZ - \u010Cesk\u00E1 republika" . "Urb\u00E1nek, Karel" . . "Vancomycin removal during low-flux and high-flux extended daily hemodialysis in critically ill septic patients"@en . . . "Vancomycin removal during low-flux and high-flux extended daily hemodialysis in critically ill septic patients" . "6"^^ . . . "RIV/61989592:15110/12:33138910!RIV13-MZ0-15110___" . . "1"^^ . "\u010Euricov\u00E1, Jana" . "Kac\u00ED\u0159ov\u00E1, Ivana" . "176954" . . "Grundmann, Milan" . . "RIV/61989592:15110/12:33138910" . "vancomycin; sepsis; polysulphone membrane; low-flux; high-flux; hemodialysis; acute kidney injury"@en . . . "To determine the extent of vancomycin removal and vancomycin pharmacokinetics in septic patients with AKI using daily hemodialysis with polysulphone high-flux and low-flux membrane. Five patients received 6 h daily dialysis with low-flux polysulphone membrane, four patients with high-flux polysulphone membrane. Vancomycin was administered over the last hour of dialysis. The maintenance dose was adjusted based on pre-hemodialysis serum concentrations. Patients were followed up for two days. Median percentage of vancomycin removal by low-flux membrane dialysis was 17% (8 - 38%) and by high-flux membrane dialysis was 31% (13-43%). Vancomycin clearance was only moderately higher in high-flux membrane dialysis (median 3.01 l/h, range 2.34-3.5 l/h) compared to low-flux dialysis (median 2.48 l/h, range 0.53-5.68 l/h) in the first day of the study. About two-fold higher vancomycin clearance in high-flux dialysis (median 3.62 l/h, range 1.37-5.07 l/h) was observed on the second day of the study than low-flux dialysis (median 1.74 l/h, range 0.75-30.94 l/h). Both high-flux and low-flux membrane dialysis remove considerable amounts of vancomycin in critically ill septic patients with AKI. Application of vancomycin after each dialysis was required to maintain therapeutic concentrations."@en . . "8"^^ . . "4" . . . "To determine the extent of vancomycin removal and vancomycin pharmacokinetics in septic patients with AKI using daily hemodialysis with polysulphone high-flux and low-flux membrane. Five patients received 6 h daily dialysis with low-flux polysulphone membrane, four patients with high-flux polysulphone membrane. Vancomycin was administered over the last hour of dialysis. The maintenance dose was adjusted based on pre-hemodialysis serum concentrations. Patients were followed up for two days. Median percentage of vancomycin removal by low-flux membrane dialysis was 17% (8 - 38%) and by high-flux membrane dialysis was 31% (13-43%). Vancomycin clearance was only moderately higher in high-flux membrane dialysis (median 3.01 l/h, range 2.34-3.5 l/h) compared to low-flux dialysis (median 2.48 l/h, range 0.53-5.68 l/h) in the first day of the study. About two-fold higher vancomycin clearance in high-flux dialysis (median 3.62 l/h, range 1.37-5.07 l/h) was observed on the second day of the study than low-flux dialysis (median 1.74 l/h, range 0.75-30.94 l/h). Both high-flux and low-flux membrane dialysis remove considerable amounts of vancomycin in critically ill septic patients with AKI. Application of vancomycin after each dialysis was required to maintain therapeutic concentrations." . . . "Biomedical Papers-Olomouc" . "P(NS10309), V" . "Petejov\u00E1, Nad\u011B\u017Eda" . .