"Klinick\u00E1 biochemie a metabolismus" . "RIV/61989592:15110/12:33138670" . "Onemocn\u011Bn\u00ED z depozice lehk\u00FDch \u0159et\u011Bzc\u016F imunoglobulinu (light chain deposition disease)" . . . "\u0160\u010Dudla, Vlastimil" . "156528" . "[456D9167276D]" . "The aim of the paper within the background of the diagnostics and treatment of three patients is the summary of recent knowledge about a relatively rare disease which is characterized by the deposition of immunoglobulin light chains in vital tissues and organs, especially the kidneys, leading to progressive deterioration of their function with end stage organ failure. We demonstrate the etiopathogenesis a differentiation of idiopathic form of the disease from the form accompanying multiple myeloma or other B-lymphoproliferative diseases, the clinical manifestation, diagnostics and differential diagnostics and therapy as well as the contribution of biological treatment using bortezomib and high dosed chemotherapy with the support of autologous stem cell transplantation, leading to a substantial improvement of the quality of life and overall survival in patients with this prognostically unfavorable disease."@en . "Onemocn\u011Bn\u00ED z depozice lehk\u00FDch \u0159et\u011Bzc\u016F imunoglobulinu (light chain deposition disease)"@cs . . . . "Onemocn\u011Bn\u00ED z depozice lehk\u00FDch \u0159et\u011Bzc\u016F imunoglobulinu (light chain deposition disease)" . . . "CZ - \u010Cesk\u00E1 republika" . "N\u00E1pln\u00ED sd\u011Blen\u00ED je, na pozad\u00ED rozboru diagnostiky a l\u00E9\u010Dby vlastn\u00EDch t\u0159\u00ED nemocn\u00FDch, pod\u00E1n\u00ED sou\u010Dasn\u00FDch poznatk\u016F o pom\u011Brn\u011B vz\u00E1cn\u00E9m a v b\u011B\u017En\u00E9 klinick\u00E9 praxi opom\u00EDjen\u00E9m onemocn\u011Bn\u00ED, vyzna\u010Duj\u00EDc\u00EDm se depozic\u00ED lehk\u00E9ho \u0159et\u011Bzce imunoglobulinu v tk\u00E1n\u00EDch \u017Eivotn\u011B d\u016Fle\u017Eit\u00FDchn org\u00E1n\u016F. Onemocn\u011Bn\u00ED z depozice lehk\u00FDch \u0159et\u011Bzc\u016F imunoglobulinu postihuje p\u0159edev\u0161\u00EDm ledviny a vede k progresivn\u00ED poru\u0161e funkce s kone\u010Dn\u00FDm org\u00E1nov\u00FDm selh\u00E1n\u00EDm. Krom\u011B etiopatogeneze, odli\u0161en\u00ED idiopatick\u00E9 formy od formy prov\u00E1zej\u00EDc\u00ED mnoho\u010Detn\u00FD myelom a vz\u00E1cn\u011B i jin\u00E9 B-lymfoproliferativn\u00ED stavy, je nast\u00EDn\u011Bna problematika klinick\u00FDch projev\u016F, diagnostiky, diferenci\u00E1ln\u00ED diagnostiky a terapie v\u010Detn\u011B p\u0159\u00EDnosu biologick\u00E9 l\u00E9\u010Dby bortezomibem a vysokod\u00E1vkovan\u00E9 chemoterapie s podporou autologn\u00EDch kmenov\u00FDch bun\u011Bk, vedouc\u00ED k podstatn\u00E9mu zlep\u0161en\u00ED kvality i celkov\u00E9 d\u00E9lky \u017Eivota nemocn\u00FDcn s touto prognosticky st\u00E1le z\u00E1va\u017Enou nemoc\u00ED." . "1210-7921" . "Pika, Tom\u00E1\u0161" . . "2" . "Onemocn\u011Bn\u00ED z depozice lehk\u00FDch \u0159et\u011Bzc\u016F imunoglobulinu (light chain deposition disease)"@cs . "15110" . "P(NT12451)" . "autologous stem cell transplantation; bortezomib; therapy; diagnostic criteria; light chain kappa/lambda index of monoclonality; light chain deposition disease"@en . "N\u00E1pln\u00ED sd\u011Blen\u00ED je, na pozad\u00ED rozboru diagnostiky a l\u00E9\u010Dby vlastn\u00EDch t\u0159\u00ED nemocn\u00FDch, pod\u00E1n\u00ED sou\u010Dasn\u00FDch poznatk\u016F o pom\u011Brn\u011B vz\u00E1cn\u00E9m a v b\u011B\u017En\u00E9 klinick\u00E9 praxi opom\u00EDjen\u00E9m onemocn\u011Bn\u00ED, vyzna\u010Duj\u00EDc\u00EDm se depozic\u00ED lehk\u00E9ho \u0159et\u011Bzce imunoglobulinu v tk\u00E1n\u00EDch \u017Eivotn\u011B d\u016Fle\u017Eit\u00FDchn org\u00E1n\u016F. Onemocn\u011Bn\u00ED z depozice lehk\u00FDch \u0159et\u011Bzc\u016F imunoglobulinu postihuje p\u0159edev\u0161\u00EDm ledviny a vede k progresivn\u00ED poru\u0161e funkce s kone\u010Dn\u00FDm org\u00E1nov\u00FDm selh\u00E1n\u00EDm. Krom\u011B etiopatogeneze, odli\u0161en\u00ED idiopatick\u00E9 formy od formy prov\u00E1zej\u00EDc\u00ED mnoho\u010Detn\u00FD myelom a vz\u00E1cn\u011B i jin\u00E9 B-lymfoproliferativn\u00ED stavy, je nast\u00EDn\u011Bna problematika klinick\u00FDch projev\u016F, diagnostiky, diferenci\u00E1ln\u00ED diagnostiky a terapie v\u010Detn\u011B p\u0159\u00EDnosu biologick\u00E9 l\u00E9\u010Dby bortezomibem a vysokod\u00E1vkovan\u00E9 chemoterapie s podporou autologn\u00EDch kmenov\u00FDch bun\u011Bk, vedouc\u00ED k podstatn\u00E9mu zlep\u0161en\u00ED kvality i celkov\u00E9 d\u00E9lky \u017Eivota nemocn\u00FDcn s touto prognosticky st\u00E1le z\u00E1va\u017Enou nemoc\u00ED."@cs . . "Light chain deposition disease"@en . "Tich\u00FD, Tom\u00E1\u0161" . . . "RIV/61989592:15110/12:33138670!RIV13-MZ0-15110___" . . "Zadra\u017Eil, Josef" . . "Krej\u010D\u00ED, Karel" . . . "5"^^ . "Mina\u0159\u00EDk, Ji\u0159\u00ED" . . . "7"^^ . . . . . . "6"^^ . . "Light chain deposition disease"@en . "20(41)" .