. . "Mikrodial\u00FDza je dynamicky se rozv\u00EDjej\u00EDc\u00ED technika vyu\u017E\u00EDvan\u00E1 k monitorov\u00E1n\u00ED tk\u00E1\u0148ov\u00E9ho metabolizmu, bari\u00E9rov\u00E9 funkce a k farmakologick\u00FDm studi\u00EDm a odhad\u016Fm lok\u00E1ln\u00ED krevn\u00ED perf\u00FAze in situ. P\u0159edkl\u00E1dan\u00FD souhrnn\u00FD \u010Dl\u00E1nek p\u0159ibli\u017Euje \u010Dten\u00E1\u0159i posledn\u00ED z uveden\u00FDch aplikac\u00ED, p\u0159i\u010Dem\u017E popisuje a srovn\u00E1v\u00E1 2 vyu\u017E\u00EDvan\u00E9 p\u0159\u00EDstupy - mikrodialyza\u010Dn\u00ED dilu\u010Dn\u00ED techniky s vyu\u017Eit\u00EDm pr\u016Ftokov\u00FDch indik\u00E1tor\u016F a kontinu\u00E1ln\u00ED metabolick\u00E9 sledov\u00E1n\u00ED. V sou\u010Dasn\u00E9 dob\u011B je up\u0159ednost\u0148ov\u00E1no vyu\u017Eit\u00ED metabolick\u00FDch indik\u00E1tor\u016F, pomoc\u00ED nich\u017E lze citliv\u011Bji a komplexn\u011Bji hodnotit perfuz\u00ED navozen\u00E9 zm\u011Bny ve tk\u00E1n\u00EDch. P\u0159es mnoh\u00E9 v\u00FDhody z\u016Fst\u00E1v\u00E1 m\u011B\u0159en\u00ED tk\u00E1\u0148ov\u00E9 perfuze pomoc\u00ED mikrodial\u00FDzy zat\u00EDm soust\u0159ed\u011Bno v oblasti klinick\u00E9ho v\u00FDzkumu. Pro \u0161ir\u0161\u00ED p\u0159ijet\u00ED a uplatn\u011Bn\u00ED v rutinn\u00EDch klinick\u00FDch postupech bude nutn\u00E9 prov\u00E9st v\u00EDce valida\u010Dn\u00EDch studi\u00ED a identifikovat situace, kde by mikrodial\u00FDza mohla nahradit st\u00E1vaj\u00EDc\u00ED metody."@cs . . "8"^^ . . "Cibi\u010Dek, Norbert" . "Modes of tissue blood perfusion assessment by microdialysis - a review of current knowledge"@en . "Mikrodial\u00FDza je dynamicky se rozv\u00EDjej\u00EDc\u00ED technika vyu\u017E\u00EDvan\u00E1 k monitorov\u00E1n\u00ED tk\u00E1\u0148ov\u00E9ho metabolizmu, bari\u00E9rov\u00E9 funkce a k farmakologick\u00FDm studi\u00EDm a odhad\u016Fm lok\u00E1ln\u00ED krevn\u00ED perf\u00FAze in situ. P\u0159edkl\u00E1dan\u00FD souhrnn\u00FD \u010Dl\u00E1nek p\u0159ibli\u017Euje \u010Dten\u00E1\u0159i posledn\u00ED z uveden\u00FDch aplikac\u00ED, p\u0159i\u010Dem\u017E popisuje a srovn\u00E1v\u00E1 2 vyu\u017E\u00EDvan\u00E9 p\u0159\u00EDstupy - mikrodialyza\u010Dn\u00ED dilu\u010Dn\u00ED techniky s vyu\u017Eit\u00EDm pr\u016Ftokov\u00FDch indik\u00E1tor\u016F a kontinu\u00E1ln\u00ED metabolick\u00E9 sledov\u00E1n\u00ED. V sou\u010Dasn\u00E9 dob\u011B je up\u0159ednost\u0148ov\u00E1no vyu\u017Eit\u00ED metabolick\u00FDch indik\u00E1tor\u016F, pomoc\u00ED nich\u017E lze citliv\u011Bji a komplexn\u011Bji hodnotit perfuz\u00ED navozen\u00E9 zm\u011Bny ve tk\u00E1n\u00EDch. P\u0159es mnoh\u00E9 v\u00FDhody z\u016Fst\u00E1v\u00E1 m\u011B\u0159en\u00ED tk\u00E1\u0148ov\u00E9 perfuze pomoc\u00ED mikrodial\u00FDzy zat\u00EDm soust\u0159ed\u011Bno v oblasti klinick\u00E9ho v\u00FDzkumu. Pro \u0161ir\u0161\u00ED p\u0159ijet\u00ED a uplatn\u011Bn\u00ED v rutinn\u00EDch klinick\u00FDch postupech bude nutn\u00E9 prov\u00E9st v\u00EDce valida\u010Dn\u00EDch studi\u00ED a identifikovat situace, kde by mikrodial\u00FDza mohla nahradit st\u00E1vaj\u00EDc\u00ED metody." . . "CZ - \u010Cesk\u00E1 republika" . . "0042-773X" . "Modes of tissue blood perfusion assessment by microdialysis - a review of current knowledge"@en . "[1937E9595185]" . . "58" . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "1"^^ . "Zp\u016Fsoby hodnocen\u00ED krevn\u00ED perfuze tk\u00E1n\u00ED pomoc\u00ED interstici\u00E1ln\u00ED mikrodial\u00FDzy - p\u0159ehled sou\u010Dasn\u00FDch znalost\u00ED" . "I, Z(MSM6198959216)" . . "Zp\u016Fsoby hodnocen\u00ED krevn\u00ED perfuze tk\u00E1n\u00ED pomoc\u00ED interstici\u00E1ln\u00ED mikrodial\u00FDzy - p\u0159ehled sou\u010Dasn\u00FDch znalost\u00ED"@cs . . "continuous metabolic monitoring; flow indicators; dilution techniques; local blood perfusion; tissue metabolism; microdialysis"@en . . "Microdialysis is a dynamically evolving method utilized for monitoring of tissue metabolism and barrier function, pharmacological studies and to estimate local blood perfusion in situ. The present review summarizes current knowledge of the last of the aforementioned applications on a characterization and comparison of two approaches used - microdialysis flow-indicator dilution technique and continuous metabolic monitoring. Currently, the use of metabolic indicators, which enable sensitive and complex evaluation of perfusion-induced changes in the tissue, is preferred. Despite the method's numerous advantages the measurement of tissue blood perfusion by microdialysis remains centralized in the area of clinical research, for the present. For wider acceptance and exercise in the routine clinical practice, more validating studies ought to be conducted and situations identified, where microdialysis could replace the current methods."@en . "RIV/61989592:15110/12:33138580!RIV13-MSM-15110___" . "1"^^ . . "Zp\u016Fsoby hodnocen\u00ED krevn\u00ED perfuze tk\u00E1n\u00ED pomoc\u00ED interstici\u00E1ln\u00ED mikrodial\u00FDzy - p\u0159ehled sou\u010Dasn\u00FDch znalost\u00ED" . "15110" . . . "183007" . . . . "1" . . . . . "Zp\u016Fsoby hodnocen\u00ED krevn\u00ED perfuze tk\u00E1n\u00ED pomoc\u00ED interstici\u00E1ln\u00ED mikrodial\u00FDzy - p\u0159ehled sou\u010Dasn\u00FDch znalost\u00ED"@cs . "RIV/61989592:15110/12:33138580" .