. . "Pikalov\u00E1, Zuzana" . "9"^^ . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "In 2008, the World Health Organization (WHO) revised its classification of hematopoietic neoplasms and new %22acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)%22 was defined as !AML arising from a previous MDS or MDS/MPN, AML with an MDS-related cytogenetic abnormality, and/or AML-MLD changes, mainly with a complex karyotype! (1). Myelodyplastic syndrome (MDS)-related chromosomal changes involve mainly aberrations of chromosomes 5, 7, and a complex karyotype. The change from ploidy to tetraploidy (4n) is a rare chromosomal abnormality in AML, and only a few cases have been described in the literature (2,3). Despite its rarity in AML, tetraploidization can initiate chromosomal instability (CIN) and promote cell transformation (4,5). Presented here is a case of a 52-year-old male with an initial diagnosis of AML-MRC with tetraploid clones detected in his bone marrow. FISH analysis revealed a large deleted derivative chromosome 5 within a complex caryotype. To the best of our knowledge, such findings in AML-MRC have not yet been reported in the literature." . "[A07EE1E9731C]" . . "36" . . . . "RIV/61989592:15110/12:33138480" . "Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)" . "Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)" . "Mi\u010Dkov\u00E1, Pavla" . "Hub\u00E1\u010Dek, Jarom\u00EDr" . "Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)"@en . . . . "Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)"@en . . "0145-2126" . . "Indr\u00E1k, Karel" . "Papaj\u00EDk, Tom\u00E1\u0161" . . "4" . . "10.1016/j.leukres.2011.12.014" . . . . "Leukemia Research" . "S, Z(MSM6198959205)" . . "Nedomov\u00E1, Radka" . "In 2008, the World Health Organization (WHO) revised its classification of hematopoietic neoplasms and new %22acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)%22 was defined as !AML arising from a previous MDS or MDS/MPN, AML with an MDS-related cytogenetic abnormality, and/or AML-MLD changes, mainly with a complex karyotype! (1). Myelodyplastic syndrome (MDS)-related chromosomal changes involve mainly aberrations of chromosomes 5, 7, and a complex karyotype. The change from ploidy to tetraploidy (4n) is a rare chromosomal abnormality in AML, and only a few cases have been described in the literature (2,3). Despite its rarity in AML, tetraploidization can initiate chromosomal instability (CIN) and promote cell transformation (4,5). Presented here is a case of a 52-year-old male with an initial diagnosis of AML-MRC with tetraploid clones detected in his bone marrow. FISH analysis revealed a large deleted derivative chromosome 5 within a complex caryotype. To the best of our knowledge, such findings in AML-MRC have not yet been reported in the literature."@en . "RIV/61989592:15110/12:33138480!RIV13-MSM-15110___" . . . "FISH analysis; chromosomal changes; myelodysplastic syndrome"@en . "Holzerov\u00E1, Milena" . . "164118" . . "Katrincs\u00E1kov\u00E1, Be\u00E1ta" . "Jaro\u0161ov\u00E1, Marie" . . "3"^^ . . . "15110" . "9"^^ . .