. "Gregar, Jan" . . . . . "Urb\u00E1nek, Karel" . . "4" . . . "S" . . "Interactions of proton pump inhibitors"@en . . "15110" . "Pharmacokinetic interactions of proton pump inhibitors (PPIs) can occur mainly during absorption and metabolisation. Important interactions of PPIs are decreased absorption of azole antimycotics, inhibition of metabolism of diazepam and moclobemide, and clopidogrel activation by cytochrome P450 2C19. Inhibition of CYP3A4 can cause an increase in plasma concentrations of tacrolimus. The lowest risk of interactions during metabolism has been found in pantoprazole. During the elimination phase, the excretion of methotrexate can be decreased by inhibition of the proton pump in the renal tubules."@en . . "Interactions of proton pump inhibitors"@en . "25" . "RIV/61989592:15110/11:10225092" . "pantoprazole; omeprazole; pharmacokinetics; drug interactions; proton pump inhibitors"@en . . "[AFE18F968797]" . "L\u00E9kov\u00E9 interakce inhibitor\u016F protonov\u00E9 pumpy" . "Farmakokinetick\u00E9 interakce inhibitor\u016F protonov\u00E9 pumpy (PPI) mohou nastat p\u0159edev\u0161\u00EDm ve f\u00E1zi absorpce a eliminace. Mezi nejv\u00FDznamn\u011Bj\u0161\u00ED pat\u0159\u00ED sn\u00ED\u017Een\u00ED vst\u0159eb\u00E1v\u00E1n\u00ED azolov\u00FDch antimykotik a inhibice metabolizmu diazepamu, moklobemidu a aktivace klopidogrelu na cytochromu P450 2C19. Inhibic\u00ED CYP3A4 mohou PPI zvy\u0161ovat plazmatick\u00E9 koncentrace takrolimu. Nejmen\u0161\u00ED interak\u010Dn\u00ED potenci\u00E1l ve f\u00E1zi metabolizmu vykazuje pantoprazol. Ve f\u00E1zi eliminace doch\u00E1z\u00ED ke sn\u00ED\u017Een\u00ED vylu\u010Dov\u00E1n\u00ED metotrex\u00E1tu inhibic\u00ED protonov\u00E9 pumpy v ledvinov\u00FDch tubulech."@cs . . "\u0160imkov\u00E1, Ivona" . . "L\u00E9kov\u00E9 interakce inhibitor\u016F protonov\u00E9 pumpy" . "L\u00E9kov\u00E9 interakce inhibitor\u016F protonov\u00E9 pumpy"@cs . "CZ - \u010Cesk\u00E1 republika" . "Klinick\u00E1 farmakologie a farmacie" . "L\u00E9kov\u00E9 interakce inhibitor\u016F protonov\u00E9 pumpy"@cs . . "Farmakokinetick\u00E9 interakce inhibitor\u016F protonov\u00E9 pumpy (PPI) mohou nastat p\u0159edev\u0161\u00EDm ve f\u00E1zi absorpce a eliminace. Mezi nejv\u00FDznamn\u011Bj\u0161\u00ED pat\u0159\u00ED sn\u00ED\u017Een\u00ED vst\u0159eb\u00E1v\u00E1n\u00ED azolov\u00FDch antimykotik a inhibice metabolizmu diazepamu, moklobemidu a aktivace klopidogrelu na cytochromu P450 2C19. Inhibic\u00ED CYP3A4 mohou PPI zvy\u0161ovat plazmatick\u00E9 koncentrace takrolimu. Nejmen\u0161\u00ED interak\u010Dn\u00ED potenci\u00E1l ve f\u00E1zi metabolizmu vykazuje pantoprazol. Ve f\u00E1zi eliminace doch\u00E1z\u00ED ke sn\u00ED\u017Een\u00ED vylu\u010Dov\u00E1n\u00ED metotrex\u00E1tu inhibic\u00ED protonov\u00E9 pumpy v ledvinov\u00FDch tubulech." . . "3"^^ . "1212-7973" . "4"^^ . . "3"^^ . "209303" . . . "RIV/61989592:15110/11:10225092!RIV12-MSM-15110___" .