. "MI\u010COV\u00C1, Kate\u0159ina" . "ADAM, Tom\u00E1\u0161" . "tandem mass spectrometry; ultra-high-perfromance liquid chromatography; leukemia; breast cancer; Tyrosine kinase inhibitors"@en . . . "CZ - \u010Cesk\u00E1 republika" . "Determination of tyrosine kinase inhibitors by UHPLC-MS/MS method"@en . "Faber, Edgar" . "0009-2770" . "FRIEDECK\u00DD, David" . . . "Stanoven\u00ED hladiny tyrosinkinasov\u00FDch inhibitor\u016F metodou UHPLC-MS/MS"@cs . . "RIV/61989592:15110/10:10215585!RIV11-MZ0-15110___" . "POL\u00DDNKOV\u00C1, Adriana" . "5"^^ . "Stanoven\u00ED hladiny tyrosinkinasov\u00FDch inhibitor\u016F metodou UHPLC-MS/MS" . . . . "Determination of tyrosine kinase inhibitors by UHPLC-MS/MS method"@en . "Stanoven\u00ED hladiny tyrosinkinasov\u00FDch inhibitor\u016F metodou UHPLC-MS/MS"@cs . . "Chemick\u00E9 listy" . . "14" . . "RIV/61989592:15110/10:10215585" . "4"^^ . "The aim of this study was to develop new rapid and sensitive UHPLC method with tandem mass spectrometry detection for determination of tyrosine kinase inhibitiors dasatinib, nilotinib, lapatinib and imatinib in plasma of patients with chronic myeloid leukemia and breast cancer. Sample preparation was based on protein precipitation by methanol with addition of internal standard (D8-imatinib), sonication, shaking, freezing and centrifugation. The separation was achieved on a 1.7 ?m C18 column with a linear gradient (4 mM NH4COOH and AcCN; pH 3.2) in a flow rate of 0.5 mL/min. Tandem mass spectrometer (triple quadrupole detector) in positive ESI were used for detection. Instrument operated in multiple-reaction monitoring (MRM) mode (m/z transitions for IM 494?394, CGP74588 480?394, D8-IM 502?394, NIL 531?290, and for LAP 582?366). The total analysis time was 3.2 min. This assay is suitable for TKI therapeutic monitoring in plasma of patients with chronic myeloid leukemia and breast cancer."@en . "4"^^ . . "Stanoven\u00ED hladiny tyrosinkinasov\u00FDch inhibitor\u016F metodou UHPLC-MS/MS" . "C\u00EDlem t\u00E9to studie bylo vyvinout novou rychlou a citlivou UHPLC metodu ve spojen\u00ED s tandemovou hmotnost\u00ED spektrometri\u00ED pro stanoven\u00ED tyrosinkinasov\u00FDch inhibitor\u016F imatinibu, dasatinibu, nilotinibu a lapatinibu v plasm\u011B pacient\u016F s chronickou myeloidn\u00ED leukemi\u00ED a rakovinou prsu. P\u0159\u00EDprava vzorku byla zalo\u017Eena na vysr\u00E1\u017Een\u00ED protein\u016F pomoc\u00ED methanolu s p\u0159\u00EDdavkem intern\u00EDho standardu (D8-imatinib), sonifikace, t\u0159ep\u00E1n\u00ED, mrazen\u00ED a centrifugaci. Separace byla provedena na 1.7 ?m C18 kolon\u011B s line\u00E1rn\u00EDm gradientem (4 mM NH4COOH and AcCN; pH 3.2) p\u0159i pr\u016Ftokov\u00E9 rychlosti 0.5 mL/min. Pro detekci byl pou\u017Eit tandemov\u00FD hmotnostn\u00ED spektrometr (trojit\u00FD kvadrupol) s ionizac\u00ED elektrosprejem v pozitivn\u00EDm m\u00F3du. P\u0159\u00EDstroj pracoval v multiple-reaction monitoring (MRM) m\u00F3du (m/z p\u0159echody pro IM 494?394, D8-IM 502?394, NIL 531?290 a pro LAP 582?366). Celkov\u00E1 doba anal\u00FDzy byla 3.2 minuty. Tato metoda je vhodn\u00E1 pro terapeutick\u00E9 monitorov\u00E1n\u00ED plasmatick\u00FDch hladin TKI u pacient\u016F s chronickou myeloidn\u00ED leukemi\u00ED a rakovinou prsu."@cs . "[EA744488D38D]" . . . "15110" . "289697" . "104" . . . . "C\u00EDlem t\u00E9to studie bylo vyvinout novou rychlou a citlivou UHPLC metodu ve spojen\u00ED s tandemovou hmotnost\u00ED spektrometri\u00ED pro stanoven\u00ED tyrosinkinasov\u00FDch inhibitor\u016F imatinibu, dasatinibu, nilotinibu a lapatinibu v plasm\u011B pacient\u016F s chronickou myeloidn\u00ED leukemi\u00ED a rakovinou prsu. P\u0159\u00EDprava vzorku byla zalo\u017Eena na vysr\u00E1\u017Een\u00ED protein\u016F pomoc\u00ED methanolu s p\u0159\u00EDdavkem intern\u00EDho standardu (D8-imatinib), sonifikace, t\u0159ep\u00E1n\u00ED, mrazen\u00ED a centrifugaci. Separace byla provedena na 1.7 ?m C18 kolon\u011B s line\u00E1rn\u00EDm gradientem (4 mM NH4COOH and AcCN; pH 3.2) p\u0159i pr\u016Ftokov\u00E9 rychlosti 0.5 mL/min. Pro detekci byl pou\u017Eit tandemov\u00FD hmotnostn\u00ED spektrometr (trojit\u00FD kvadrupol) s ionizac\u00ED elektrosprejem v pozitivn\u00EDm m\u00F3du. P\u0159\u00EDstroj pracoval v multiple-reaction monitoring (MRM) m\u00F3du (m/z p\u0159echody pro IM 494?394, D8-IM 502?394, NIL 531?290 a pro LAP 582?366). Celkov\u00E1 doba anal\u00FDzy byla 3.2 minuty. Tato metoda je vhodn\u00E1 pro terapeutick\u00E9 monitorov\u00E1n\u00ED plasmatick\u00FDch hladin TKI u pacient\u016F s chronickou myeloidn\u00ED leukemi\u00ED a rakovinou prsu." . . . . . "P(NS9627), Z(MSM6198959205)" .