. "This invention relates to new disubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially in cancer therapy and agricultural practice. The compounds are antimitotic, anticancer, herbicidal, fungicidal and insecticidal having improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known. It is an object of this invention to provide 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines.The solution of this object are 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I." . "Strnad, Miroslav" . "1"^^ . "Mnichov" . "HAVL\u00CD\u010CEK, Libor" . "Schmulling, Thomas" . "Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use" . "RIV/61989592:15110/10:10212649" . "Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use"@en . . "[36C3D31EB419]" . . . "Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use"@en . . "This invention relates to new disubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially in cancer therapy and agricultural practice. The compounds are antimitotic, anticancer, herbicidal, fungicidal and insecticidal having improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known. It is an object of this invention to provide 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines.The solution of this object are 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I."@en . "\u00DAstav experimentalni botaniky Akademie v\u011Bd \u010Cesk\u00E9 republiky, Univerzita Palack\u00E9ho v Olomouci" . "10"^^ . "Lenobel, Ren\u00E9" . "Moravcov\u00E1, Daniela" . . . "15110" . "283526" . . "EP1475094" . "P(GA301/08/1649), P(GA522/09/1576)" . "VOJT\u011A\u0160EK, Bo\u0159ivoj" . "RIV/61989592:15110/10:10212649!RIV11-GA0-15110___" . . "Binarov\u00E1, Pavla" . . . . . . . "Uldrijan, Stjepan" . . "MLEJNEK, Petr" . . "The European Patent Office (EPO)" . . . . "Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use" . . "Kry\u0161tof, Vladim\u00EDr" . "2010-07-28+02:00"^^ . "methods; preparation; process; Pyrazolo[4,3-D]pyrimidines,"@en . . . .