. "23" . "RIV/61989592:15110/09:00009614!RIV10-MSM-15110___" . . . "C\u00EDlem in vitro studie bylo z\u00EDskat informace o mo\u017Enosti interakce rokuronia s lidsk\u00FDm jatern\u00EDm mikrosom\u00E1ln\u00EDm syst\u00E9mem cytochrom\u016F P450, zejm\u00E9na s formou cytochromu P450 3A4. Metody: Interakce rokuronia s mikrosom\u00E1ln\u00EDmi cytochromy P450 byla sledov\u00E1na spektrofotometricky pomoc\u00ED diferen\u010Dn\u00ED absorp\u010Dn\u00ED spektroskopie. Interakce s cytochromem P450, formou CYP3A4, byla sledov\u00E1na pomoc\u00ED inhibice specifick\u00E9 aktivity CYP3A4 (testosteron 6\u03B2-hydroxylace). V\u00FDsledky: Rokuronium interaguje in vitro s lidsk\u00FDmi jatern\u00EDmi mikrosom\u00E1ln\u00EDmi cytochromy P450 a inhibuje \u00FA\u010Dinn\u011B aktivitu formy CYP3A4. Z\u00E1v\u011Br: Vzhledem k tomu, \u017Ee tato forma metabolizuje l\u00E1tky steroidn\u00ED povahy, je mo\u017En\u00FD vliv interakce rokuronia na dal\u0161\u00ED procesy v organizmu. Nelze rovn\u011B\u017E vylou\u010Dit i mo\u017Enost l\u00E9kov\u00FDch interakc\u00ED rokuronia s l\u00E9\u010Divy metabolizovan\u00FDmi CYP3A4, kter\u00E9 by mohly nap\u0159. v\u00E9st k prodlou\u017Een\u00ED \u00FA\u010Dinku rokuronia." . "CZ - \u010Cesk\u00E1 republika" . "3"^^ . "3" . "Klinick\u00E1 farmakologie a farmacie" . . . "Z(MSM6198959216)" . "C\u00EDlem in vitro studie bylo z\u00EDskat informace o mo\u017Enosti interakce rokuronia s lidsk\u00FDm jatern\u00EDm mikrosom\u00E1ln\u00EDm syst\u00E9mem cytochrom\u016F P450, zejm\u00E9na s formou cytochromu P450 3A4. Metody: Interakce rokuronia s mikrosom\u00E1ln\u00EDmi cytochromy P450 byla sledov\u00E1na spektrofotometricky pomoc\u00ED diferen\u010Dn\u00ED absorp\u010Dn\u00ED spektroskopie. Interakce s cytochromem P450, formou CYP3A4, byla sledov\u00E1na pomoc\u00ED inhibice specifick\u00E9 aktivity CYP3A4 (testosteron 6\u03B2-hydroxylace). V\u00FDsledky: Rokuronium interaguje in vitro s lidsk\u00FDmi jatern\u00EDmi mikrosom\u00E1ln\u00EDmi cytochromy P450 a inhibuje \u00FA\u010Dinn\u011B aktivitu formy CYP3A4. Z\u00E1v\u011Br: Vzhledem k tomu, \u017Ee tato forma metabolizuje l\u00E1tky steroidn\u00ED povahy, je mo\u017En\u00FD vliv interakce rokuronia na dal\u0161\u00ED procesy v organizmu. Nelze rovn\u011B\u017E vylou\u010Dit i mo\u017Enost l\u00E9kov\u00FDch interakc\u00ED rokuronia s l\u00E9\u010Divy metabolizovan\u00FDmi CYP3A4, kter\u00E9 by mohly nap\u0159. v\u00E9st k prodlou\u017Een\u00ED \u00FA\u010Dinku rokuronia."@cs . . . . . . . "15110" . . "Mo\u017En\u00E9 interakce rokuronia s jatern\u00EDmi mikrosom\u00E1ln\u00EDmi cytochromy P450." . . . "Tunkov\u00E1, Alena" . . . "Mo\u017En\u00E9 interakce rokuronia s jatern\u00EDmi mikrosom\u00E1ln\u00EDmi cytochromy P450."@cs . "On the possibility of interactions of rocuronium with liver microsomal cytochromes P450"@en . . "Anzenbacherov\u00E1, Eva" . "Mo\u017En\u00E9 interakce rokuronia s jatern\u00EDmi mikrosom\u00E1ln\u00EDmi cytochromy P450." . "On the possibility of interactions of rocuronium with liver microsomal cytochromes P450"@en . "4"^^ . "327585" . "4"^^ . "[936EB6746067]" . "Aim of the study: Aim of the study was to find whether human liver microsomal cytochromes P450 interact with rocuronium in vitro. Methods: Interaction of rocuronium with microsomal cytochromes P450 was followed spectrophotometrically using difference absorption spectroscopy. Interaction with cytochrome P450 form CYP3A4 was studied by determination of inhibition of a CYP3A4-specific enzyme activity (testosterone 6\u03B2-hydroxylation) by HPLC. Results: Rocuronium interacts in vitro with human liver microsomal cytochromes P450 and inhibits effectively the CYP3A4 specific enzyme activity. Conclusion: Due to the fact that the CYP3A4 form is known to metabolize steroids and steroid-related compounds there is a possibility of an influence of rocuronium-CYP3A4 interactions on other processes in the organism. Moreover, a possibility of drug interactions with concomitantly administered drugs metabolized by CYP3A4 leading to e.g. prolongation of rocuronium effect cannot be excluded."@en . "rocuronium; metabolism; CYP3A4; cytochromes P450; rocuronium, metabolism, CYP3A4, cytochromes P450. rocuronium, metabolism, CYP3A4, cytochromes P450. rocuronium; metabolism; CYP3A4; cytochromes P450"@en . . "1212-7973" . "Mo\u017En\u00E9 interakce rokuronia s jatern\u00EDmi mikrosom\u00E1ln\u00EDmi cytochromy P450."@cs . . "RIV/61989592:15110/09:00009614" . "Adamus, Milan" . . "Anzenbacher, Pavel" .