"Mendelov\u00E1, Denisa" . "[FE564AF7AD68]" . "CZ - \u010Cesk\u00E1 republika" . "Interfant 99 ? l\u00E9\u010Debn\u00E1 studie zohled\u0148uj\u00EDc\u00ED odli\u0161nou biologii akutn\u00ED lymfoblastick\u00E9 leukemie kojenc\u016F a jej\u00ED v\u00FDsledky v \u010Cesk\u00E9 republice"@cs . "acute lymphoblastic leukemia; infants; Interfant 99 study; MLL rearrangement; t(4; 11) translocation"@en . "Houskov\u00E1, J." . . "Sm\u00ED\u0161ek, P." . "Proch\u00E1zkov\u00E1, D." . "Zemanov\u00E1, Z." . "RIV/61989592:15110/09:00009546!RIV10-MSM-15110___" . "Trka, J." . "Mejst\u0159\u00EDkov\u00E1, E." . "Kramarzov\u00E1, K." . . . . . "Akutn\u00ED lymfoblastick\u00E1 leukemie (ALL) postihuj\u00EDc\u00ED kojence je vz\u00E1cn\u00E9 onemocn\u011Bn\u00ED s biologick\u00FDm chov\u00E1n\u00EDm odli\u0161n\u00FDm od ALL d\u011Bt\u00ED star\u0161\u00EDch jednoho roku. Osmdes\u00E1t procent kojenc\u016F m\u00E1 p\u0159estavbu genu MLL v oblasti 11q23, nej\u010Dast\u011Bj\u0161\u00ED abnormalitou je translokace t(4;11)(q21;q23) s f\u00FAzn\u00EDm genem MLL-AF4. MLL+ ALL vznik\u00E1 v\u011Bt\u0161inou ve velmi nezral\u00FDch prekurzorech B lymfatick\u00E9 \u0159ady (BCP), nese sou\u010Dasn\u011B myeloidn\u00ED znaky, m\u00E1 \u010Dast\u011Bji hyperleukocyt\u00F3zu, hor\u0161\u00ED inici\u00E1ln\u00ED odpov\u011B\u010F na l\u00E9\u010Dbu a vysok\u00E9 riziko \u010Dasn\u00E9ho relapsu. D\u016Fsledkem jsou v\u00FDznamn\u011B hor\u0161\u00ED v\u00FDsledky l\u00E9\u010Dby ne\u017E u star\u0161\u00EDch d\u011Bt\u00ED a snaha konstruovat l\u00E9\u010Debn\u00E9 protokoly kombinuj\u00EDc\u00ED l\u00E9ky \u00FA\u010Dinn\u00E9 u lymfatick\u00FDch i myeloidn\u00EDch leukemi\u00ED. V letech 1990?99 byla v \u010CR diagnostikov\u00E1na ALL u 21 kojenc\u016F, z nich\u017E pouze 6 bylo l\u00E9\u010Deno protokoly zohled\u0148uj\u00EDc\u00EDmi odli\u0161nost kojeneck\u00E9 ALL. P\u011Btilet\u00FD EFS cel\u00E9 skupiny byl 33 %, z deseti d\u011Bt\u00ED s MLL-AF4+ ALL bylo vyl\u00E9\u010Deno jedin\u00E9. V obdob\u00ED 2000?2005 jsme diagnostikovali ALL u 14 kojenc\u016F a 13 z nich jsme l\u00E9\u010Dili v mezin\u00E1rodn\u00ED randomizovan\u00E9 studii INTERFANT" . . "S, Z(MSM0021620813), Z(MSM6198959205), Z(MSM6198959216), Z(MZ000064203), Z(MZ0FNM2005), Z(MZ0VFN2005)" . "8"^^ . . "Jaro\u0161ov\u00E1, Marie" . . "15" . "Mih\u00E1l, Vladim\u00EDr" . "Zuna, Jan" . "Acute lymphoblastic leukemia (ALL) affecting infants is a rare malignancy with the biological behavior different from the leukemia of older children. About 80% infants have a rearrangement of the MLL gene at the chromosomal locus 11q23. The most frequent abnormality is the t(4;11)(q21;q23) translocation producing the MLL-AF4 fusion gene. The MLL+ ALL originates usually in the immature B-cell precursors with aberrant expression of myeloid antigens. It is characterized by hyperleukocytosis, poor initial treatment response and high risk of the early relapse. Treatment results are significantly worse than in older children. Current protocols usually combine elements used in the therapy of both lymphoid and myeloid acute leukemias. Between 1990 and 1999, twenty-one infants were diagnosed with ALL in the Czech Republic and only 6 of them were treated according to a protocol designed specifically for the infants. Five-years event-free survival (EFS) was 33 %, only one out of the ten children with MLL-AF4 fus"@en . . . "\u0160t\u011Brba, Jaroslav" . . . "Interfant 99 ? l\u00E9\u010Debn\u00E1 studie zohled\u0148uj\u00EDc\u00ED odli\u0161nou biologii akutn\u00ED lymfoblastick\u00E9 leukemie kojenc\u016F a jej\u00ED v\u00FDsledky v \u010Cesk\u00E9 republice" . "Interfant 99 ? treatment reflecting unique biology of the infant acute lymphoblastic leukemia. The results in the Czech Republic"@en . "28"^^ . "320016" . "Vrzalov\u00E1, A." . "\u010Cern\u00E1, Z." . . "Interfant 99 ? l\u00E9\u010Debn\u00E1 studie zohled\u0148uj\u00EDc\u00ED odli\u0161nou biologii akutn\u00ED lymfoblastick\u00E9 leukemie kojenc\u016F a jej\u00ED v\u00FDsledky v \u010Cesk\u00E9 republice" . "Star\u00FD, Jan" . . "Hru\u0161\u00E1k, O." . "Tou\u0161ovsk\u00E1, Kate\u0159ina" . "Keslov\u00E1, P." . "15110" . "1213-5763" . "Hak, Ji\u0159\u00ED" . "RIV/61989592:15110/09:00009546" . . "2" . . "Transfuze a hematologie dnes" . "Sedl\u00E1\u010Dek, Petr" . . "Oltov\u00E1, A." . . . . "Interfant 99 ? treatment reflecting unique biology of the infant acute lymphoblastic leukemia. The results in the Czech Republic"@en . "V\u00E1vra, Vladim\u00EDr" . "Form\u00E1nkov\u00E1, R." . "Gajdo\u0161, P." . "Akutn\u00ED lymfoblastick\u00E1 leukemie (ALL) postihuj\u00EDc\u00ED kojence je vz\u00E1cn\u00E9 onemocn\u011Bn\u00ED s biologick\u00FDm chov\u00E1n\u00EDm odli\u0161n\u00FDm od ALL d\u011Bt\u00ED star\u0161\u00EDch jednoho roku. Osmdes\u00E1t procent kojenc\u016F m\u00E1 p\u0159estavbu genu MLL v oblasti 11q23, nej\u010Dast\u011Bj\u0161\u00ED abnormalitou je translokace t(4;11)(q21;q23) s f\u00FAzn\u00EDm genem MLL-AF4. MLL+ ALL vznik\u00E1 v\u011Bt\u0161inou ve velmi nezral\u00FDch prekurzorech B lymfatick\u00E9 \u0159ady (BCP), nese sou\u010Dasn\u011B myeloidn\u00ED znaky, m\u00E1 \u010Dast\u011Bji hyperleukocyt\u00F3zu, hor\u0161\u00ED inici\u00E1ln\u00ED odpov\u011B\u010F na l\u00E9\u010Dbu a vysok\u00E9 riziko \u010Dasn\u00E9ho relapsu. D\u016Fsledkem jsou v\u00FDznamn\u011B hor\u0161\u00ED v\u00FDsledky l\u00E9\u010Dby ne\u017E u star\u0161\u00EDch d\u011Bt\u00ED a snaha konstruovat l\u00E9\u010Debn\u00E9 protokoly kombinuj\u00EDc\u00ED l\u00E9ky \u00FA\u010Dinn\u00E9 u lymfatick\u00FDch i myeloidn\u00EDch leukemi\u00ED. V letech 1990?99 byla v \u010CR diagnostikov\u00E1na ALL u 21 kojenc\u016F, z nich\u017E pouze 6 bylo l\u00E9\u010Deno protokoly zohled\u0148uj\u00EDc\u00EDmi odli\u0161nost kojeneck\u00E9 ALL. P\u011Btilet\u00FD EFS cel\u00E9 skupiny byl 33 %, z deseti d\u011Bt\u00ED s MLL-AF4+ ALL bylo vyl\u00E9\u010Deno jedin\u00E9. V obdob\u00ED 2000?2005 jsme diagnostikovali ALL u 14 kojenc\u016F a 13 z nich jsme l\u00E9\u010Dili v mezin\u00E1rodn\u00ED randomizovan\u00E9 studii INTERFANT"@cs . "Interfant 99 ? l\u00E9\u010Debn\u00E1 studie zohled\u0148uj\u00EDc\u00ED odli\u0161nou biologii akutn\u00ED lymfoblastick\u00E9 leukemie kojenc\u016F a jej\u00ED v\u00FDsledky v \u010Cesk\u00E9 republice"@cs . . "Michalov\u00E1, K." . "Jabali, Y." . "3"^^ . "Posp\u00ED\u0161ilov\u00E1, Dagmar" . "Bla\u017Eek, B." . . . . . .