. . . . . . . "391832" . "5"^^ . "Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells"@en . "Cell death-inducing DFF[DNA fragmentation factor]-like effector-a (CIDEa), may initiate apoptosis by disrupting a complex consisting of 40-kDa caspase-3-activated nuclease (DFF40/CAD) and its 45-kDa inhibitor (DFF45/ICAD). CIDEa, however, was found to be localized in mitochondria. We have performed immunodetection of CIDEa in whole cells and subcellular fractions of HeLa cells adapted for a tetracycline-inducible CIDEa expression. Using immunocytochemistry we observed redistribution, enhanced upon treatment with camptothecin or valinomycin, of CIDEa to nucleus. Similarly, CIDEa content increased in the nuclear fraction but decreased in cytosolic fraction in cells treated to initiate apoptosis. We hypothesize that CIDEa is sequestered in mitochondria while transfer of this potentially dangerous protein from mitochondria into nucleus intensifies or even initiates apoptosis." . . . . "Je\u017Eek, Petr" . "Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells" . "15110" . "\u0160antorov\u00E1, Jitka" . "Cell death-inducing DFF[DNA fragmentation factor]-like effector-a (CIDEa), may initiate apoptosis by disrupting a complex consisting of 40-kDa caspase-3-activated nuclease (DFF40/CAD) and its 45-kDa inhibitor (DFF45/ICAD). CIDEa, however, was found to be localized in mitochondria. We have performed immunodetection of CIDEa in whole cells and subcellular fractions of HeLa cells adapted for a tetracycline-inducible CIDEa expression. Using immunocytochemistry we observed redistribution, enhanced upon treatment with camptothecin or valinomycin, of CIDEa to nucleus. Similarly, CIDEa content increased in the nuclear fraction but decreased in cytosolic fraction in cells treated to initiate apoptosis. We hypothesize that CIDEa is sequestered in mitochondria while transfer of this potentially dangerous protein from mitochondria into nucleus intensifies or even initiates apoptosis."@en . "CIDEa; Mitochondria; Apoptosis; Migration to nucleus; HeLa cells"@en . "Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells"@en . . "[CF1B9D40895A]" . "SK - Slovensk\u00E1 republika" . "1"^^ . . "Redistribuce CIDEa (DFFa podobn\u00FD faktor indukuj\u00EDc\u00ED bun\u011B\u010Dnou smrt) z mitochondri\u00ED do j\u00E1dra v HeLa bu\u0148k\u00E1ch"@cs . . "Z(MSM6198959216)" . "RIV/61989592:15110/08:00007375" . "Abstrakt. DFFa podobn\u00FD faktor indukuj\u00EDc\u00ED bun\u011B\u010Dnou smrt, CIDEa, m\u016F\u017Ee iniciovat apopt\u00F3zu rozlo\u017Een\u00EDm komplexu sest\u00E1vaj\u00EDc\u00EDho z nukle\u00E1zy aktivuj\u00EDc\u00ED kasp\u00E1zu-3 o velikosti 40-kDa (DFF40/CAD) a jeho inhibitoru o velikosti 45-kDa (DFF45/ICAD). Nicm\u00E9n\u011B bylo zji\u0161t\u011Bno, \u017Ee se CIDEa nach\u00E1z\u00ED v mitochodnri\u00EDch. Provedli jsme imunodetekci CIDEa v cel\u00FDch bu\u0148k\u00E1ch a subcelul\u00E1rn\u00EDch frakc\u00EDch HeLa bun\u011Bk adaptovan\u00FDch na tetracyklinem indukovanou expresi CIDEa. S vyu\u017Eit\u00EDm imunocytochemie jsem pozorovali redistribuci CIDEa do j\u00E1dra, zv\u00FD\u0161enou p\u016Fsoben\u00EDm camptothecinu nebo valinomycinu. Podobn\u011B byl obsah CIDEa zv\u00FD\u0161en\u00FD v nukle\u00E1rn\u00ED frakci a naopak sn\u00ED\u017Een\u00FD v cytosolick\u00E9 frakci v bu\u0148k\u00E1ch vedouc\u00ED k iniciaci apopt\u00F3zy. Hypot\u00E9za zn\u00ED, \u017Ee CIDEa je osamocen\u00E1 v mitochondri\u00EDch, p\u0159i\u010Dem\u017E p\u0159enos tohoto potenci\u00E1ln\u011B nebezpe\u010Dn\u00E9ho proteinu z mitochondri\u00ED do j\u00E1dra zvy\u0161uje nebo dokonce iniciuje apopt\u00F3zu."@cs . . "Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells" . "27" . "0231-5882" . "4"^^ . "RIV/61989592:15110/08:00007375!RIV09-MSM-15110___" . . "Valou\u0161kov\u00E1, Eva" . . "Modriansk\u00FD, Martin" . . "2" . "Smolkov\u00E1, Katarina" . "Redistribuce CIDEa (DFFa podobn\u00FD faktor indukuj\u00EDc\u00ED bun\u011B\u010Dnou smrt) z mitochondri\u00ED do j\u00E1dra v HeLa bu\u0148k\u00E1ch"@cs . "General Physiology and Biophysics" .