"RIV/61989592:15110/08:00007288" . . "Regulace PKC-\u00F0 a PPAR-\u03B3 energetick\u00FDmi substr\u00E1ty v bun\u011B\u010Dn\u00E9 linii HEP G2" . . "392032" . . "1"^^ . "Regulation of PKC- \u03B4 and PPAR-\u03B3 by Energy Substrates in HEPG2 Cells"@en . "Regulace PKC-\u00F0 a PPAR-\u03B3 energetick\u00FDmi substr\u00E1ty v bun\u011B\u010Dn\u00E9 linii HEP G2" . . . "Regulace PKC-\u00F0 a PPAR-\u03B3 energetick\u00FDmi substr\u00E1ty v bun\u011B\u010Dn\u00E9 linii HEP G2"@cs . "RIV/61989592:15110/08:00007288!RIV09-MSM-15110___" . "1"^^ . . . "Insulin resistance; starvation; free fatty acd (FFA); oleic acid; glucose; PKC- \u03B4; subcellular distribution; peroxisome-activated receptor gamma (PPAR-\u03B3); mRNA stability; HEPG2 cells"@en . . . . "Za \u00FA\u010Delem komplexn\u011Bj\u0161\u00EDho objasn\u011Bn\u00ED sign\u00E1ln\u00ED \u00FAlohy energetick\u00FDch substr\u00E1t\u016F ? neesterifikovan\u00FDch mastn\u00FDch kyselin a gluk\u00F3zy ? v energetick\u00E9m metabolismu byl zkoum\u00E1n jejich \u00FA\u010Dinek in vitro na aktivaci a genovou expresi kin\u00E1zy PKC-\u03B4 a na genovou expresi transkrip\u010Dn\u00EDho faktoru PPAR-\u03B3 na bun\u011B\u010Dn\u00E9 linii HepG2. Fyziologick\u00E9 koncentrace vybran\u00FDch mastn\u00FDch kyselin (n=9) s r\u016Fzn\u00FDm stupn\u011Bm saturace a jejich sm\u011Bsi neindukovaly intracelul\u00E1rn\u00ED translokaci PKC- \u03B4 ani jej\u00ED genovou expresi po akutn\u00EDch a prodlou\u017Een\u00FDch inkuba\u010Dn\u00EDch intervalech za zvolen\u00FDch experiment\u00E1ln\u00EDch podm\u00EDnek. Absence gluk\u00F3zy ani p\u0159\u00EDtomnost vysok\u00E9 hladiny gluk\u00F3zy nep\u0159isp\u011Bly ke stimulaci translokace PKC- \u03B4 do membr\u00E1n v prost\u0159ed\u00ED s kyselinou olejovou. Proto z\u016Fst\u00E1v\u00E1 p\u0159edpokl\u00E1dan\u00E1 \u00FAloha mastn\u00FDmi kyselinami aktivovan\u00E1 PKC- \u03B4 ve fyziologick\u00FDch a/nebo patofyziologick\u00FDch procesech (nap\u0159. insulinov\u00E9 rezistenci v j\u00E1trech) nejasn\u00E1." . . . . . "Regulace PKC-\u00F0 a PPAR-\u03B3 energetick\u00FDmi substr\u00E1ty v bun\u011B\u010Dn\u00E9 linii HEP G2"@cs . "[31BDD5A59B39]" . . "Za \u00FA\u010Delem komplexn\u011Bj\u0161\u00EDho objasn\u011Bn\u00ED sign\u00E1ln\u00ED \u00FAlohy energetick\u00FDch substr\u00E1t\u016F ? neesterifikovan\u00FDch mastn\u00FDch kyselin a gluk\u00F3zy ? v energetick\u00E9m metabolismu byl zkoum\u00E1n jejich \u00FA\u010Dinek in vitro na aktivaci a genovou expresi kin\u00E1zy PKC-\u03B4 a na genovou expresi transkrip\u010Dn\u00EDho faktoru PPAR-\u03B3 na bun\u011B\u010Dn\u00E9 linii HepG2. Fyziologick\u00E9 koncentrace vybran\u00FDch mastn\u00FDch kyselin (n=9) s r\u016Fzn\u00FDm stupn\u011Bm saturace a jejich sm\u011Bsi neindukovaly intracelul\u00E1rn\u00ED translokaci PKC- \u03B4 ani jej\u00ED genovou expresi po akutn\u00EDch a prodlou\u017Een\u00FDch inkuba\u010Dn\u00EDch intervalech za zvolen\u00FDch experiment\u00E1ln\u00EDch podm\u00EDnek. Absence gluk\u00F3zy ani p\u0159\u00EDtomnost vysok\u00E9 hladiny gluk\u00F3zy nep\u0159isp\u011Bly ke stimulaci translokace PKC- \u03B4 do membr\u00E1n v prost\u0159ed\u00ED s kyselinou olejovou. Proto z\u016Fst\u00E1v\u00E1 p\u0159edpokl\u00E1dan\u00E1 \u00FAloha mastn\u00FDmi kyselinami aktivovan\u00E1 PKC- \u03B4 ve fyziologick\u00FDch a/nebo patofyziologick\u00FDch procesech (nap\u0159. insulinov\u00E9 rezistenci v j\u00E1trech) nejasn\u00E1."@cs . . "Uherkov\u00E1, Lenka" . . . "15110" . . . . . . . "Regulation of PKC- \u03B4 and PPAR-\u03B3 by Energy Substrates in HEPG2 Cells"@en . "P(OC B17.20), Z(MSM6198959205)" . "In vitro effects of energy substrates-non-esterified free fatty acids (NEFAs) and glucose ?on PKC- \u03B4 activation and PPAR-\u03B3 gene expression were investigated in human hepatoma HepG2 cells to reveal their signaling action implicated in energy metabolism. Within this study, it was demonstrated that neither nine examined FFAs with a different degree of saturation nor their mixtures in near-physiological concentrations induced any alternations in subcellular distribution of PKC- \u03B4 under acute and prolonged incubations of the cells. The absence of glucose or high glucose concentration without or with oleate infuenced PKC- \u03B4 cytososl-to.membrane translocation neithe. Ths, a presumed role of FFA-stimulated PKC- \u03B4 effect in mediation of physiological and/or pathophysiological processes, e.g. hepatic insulin resistance, was not supported by the present study and still remains to be solved."@en .