. . . "Background: Discovery of uncoupling protein 2 (UCP2) in 1997 and demonstration of its wide tissue expression has triggered an important question about controlled oxidative phosphorylation uncoupling and the physiological function of this process. Uncoupling protein 2 (UcP2) is a mitochondrial protein that can infl uence the mitochondrial membrane potential and hence the production of reactive oxygen species by mitochondria. It is also thought to be involved in apoptotic signaling pathways and it has been suggested to be important in cardio- and neuroprotection. Methods and results: We examined the recent literature (2003?2007) in the MedLine database for evidence linking p38, one of the stress-related protein kinases, with modulation of UCP2 expression in the heart. While two reports clearly demonstrate p38 as down-regulating UcP2 expression, only circumstantial evidence exists for cardiomyocytes. Confl icting results on p38-regulated cardiomyocyte survival after ischemia leave an open venue f" . "1" . . . . "Profil: Objev uncoupling proteinu 2 (UCP2) v roce 1997 a demonstrace jeho exprese v mnoha tk\u00E1n\u00EDch vzbudila d\u016Fle\u017Eitou ot\u00E1zku o kontrolovan\u00E9m odp\u0159a\u017Een\u00ED oxidativn\u00ED fosforylace a fyziologick\u00E9 funkci tohoto procesu. Uncoupling protein (UCP2) je mitochondri\u00E1ln\u00ED protein, kter\u00FD m\u016F\u017Ee ovlivnit mitochondri\u00E1ln\u00ED membr\u00E1nov\u00FD potenci\u00E1l a vyvolat produkci reaktivn\u00EDch kysl\u00EDkov\u00FDch radik\u00E1l\u016F mitochondriemi. Zd\u00E1 se, \u017Ee UCP2 je zapojen do apoptotick\u00E9 sign\u00E1ln\u00ED dr\u00E1hy a je d\u016Fle\u017Eit\u00FD v kardio- a neuroprotekci. Metody a v\u00FDsledky: Pro d\u016Fkaz spojen\u00ED p38, jedn\u00E9 z proteinkin\u00E1z souvisej\u00EDc\u00ED se stresem, s modulac\u00ED exprese UCP2 v srdci jsme prov\u011B\u0159ili sou\u010Dasnou literaturu (2003-2007) v datab\u00E1zi MedLine. Zat\u00EDmco dv\u011B studie jasn\u011B ukazuj\u00ED p38 jako regul\u00E1tor sni\u017Euj\u00EDc\u00ED expresi UCP2, pro kardiomyocyty existuj\u00ED pouze nep\u0159\u00EDm\u00E9 d\u016Fkazy. Protikladn\u00E9 z\u00E1v\u011Bry o p\u0159e\u017Eit\u00ED kardiomyocyt\u016F po ischemii regulovan\u00E9 p38 vedou k otev\u0159en\u00E9mu m\u00EDstu pro hypot\u00E9zu o odli\u0161n\u00E9 regulaci exprese proteinu, zahrnuj\u00EDc\u00ED UCP2. Shrnut\u00ED: Ke zhodnocen\u00ED d\u016Fkaz\u016F spojen\u00ED UCP2 a jeh"@cs . . "Modulace exprese UCP2 p38 - souvislost s kardioprotekc\u00ED"@cs . "Background: Discovery of uncoupling protein 2 (UCP2) in 1997 and demonstration of its wide tissue expression has triggered an important question about controlled oxidative phosphorylation uncoupling and the physiological function of this process. Uncoupling protein 2 (UcP2) is a mitochondrial protein that can infl uence the mitochondrial membrane potential and hence the production of reactive oxygen species by mitochondria. It is also thought to be involved in apoptotic signaling pathways and it has been suggested to be important in cardio- and neuroprotection. Methods and results: We examined the recent literature (2003?2007) in the MedLine database for evidence linking p38, one of the stress-related protein kinases, with modulation of UCP2 expression in the heart. While two reports clearly demonstrate p38 as down-regulating UcP2 expression, only circumstantial evidence exists for cardiomyocytes. Confl icting results on p38-regulated cardiomyocyte survival after ischemia leave an open venue f"@en . "Biomedical Papers" . "380284" . "Modulation of UCP2 expression by p38 - a link to cardioprotection"@en . "Modulation of UCP2 expression by p38 - a link to cardioprotection" . . "Mitochondria; Oxidative phosphorylation; Uncoupling; Mitogen-activated protein kinase; Reactive oxygen species"@en . . . "RIV/61989592:15110/08:00006994!RIV09-MSM-15110___" . . "RIV/61989592:15110/08:00006994" . . . "P(GA303/08/0658), Z(MSM6198959216)" . "Modulation of UCP2 expression by p38 - a link to cardioprotection"@en . . . . "Valou\u0161kov\u00E1, Eva" . "Modulation of UCP2 expression by p38 - a link to cardioprotection" . "2"^^ . "152" . "Modulace exprese UCP2 p38 - souvislost s kardioprotekc\u00ED"@cs . "5"^^ . "[96FC60414613]" . "1213-8118" . "1"^^ . "Modriansk\u00FD, Martin" . . . . "CZ - \u010Cesk\u00E1 republika" . "15110" .