"8" . "Zaridze, David" . "Tato studie zkoum\u00E1 asociaci mezi pracovn\u00ED expozic\u00ED pesticid\u016Fm a riziku vzniku karcinomu z ledvinn\u00FDch bun\u011Bk (RCC). V n\u00E1vaznosti na p\u0159edchoz\u00ED publikaci Buzio a kol. jsme se zab\u00FDvali studiem, zda by tato asociace mohla b\u00FDt modifikov\u00E1na genotypy M1 a T1 glutathion S transfer\u00E1zy (GSTM1 a GSTT1).Data o celo\u017Eivotn\u00ED profesion\u00E1ln\u00ED expozici byla z\u00EDsk\u00E1na pomoc\u00ED interview od 1,097 RCC p\u0159\u00EDpad\u016F a 1,476 kontrol ze st\u0159edn\u00ED a v\u00FDchodn\u00ED Evropy. Byly hodnoceny profesion\u00E1ln\u00ED expozice, kter\u00E1 trvaly nejm\u00E9n\u011B 12 m\u011Bs\u00EDc\u016F, ty byly k\u00F3dov\u00E1ny podle expozice pesticidu a hodnoceny podle frekvence a intenzity expozice. GSTM1 a T1 genov\u00E9 delece byly analyzov\u00E1ny za pou\u017Eit\u00ED TaqMan(R) test\u016F. Signifikantn\u00ED n\u00E1r\u016Fst rizika RCC byl pozorov\u00E1n u subjekt\u016F exponovan\u00FDch pesticid\u016Fm (OR: 1.60; 95% IS: 1.00-2.55). Po stratifikaci podle genotyp\u016F bylo pozorov\u00E1no zv\u00FD\u0161en\u00E9 riziko u subjekt\u016F s nejm\u00E9n\u011B jednou GSTM1 aktivn\u00ED alelou (OR: 4.00; 95% IS: 1.55-10.33) ale ne u subjekt\u016F se dv\u011Bma inaktivn\u00EDmi alelami GSTM1, v porovn\u00E1n\u00ED s neexponovan\u00FDmi subjekty se dv\u011B"@cs . "Boffeta, Paolo" . . "Koll\u00E1rov\u00E1, Helena" . . . "RIV/61989592:15110/08:00006194!RIV09-MZ0-15110___" . "Karcinom z ledvinn\u00FDch bun\u011Bk, pracovn\u00ED expozice pesticid\u016Fm a modifikace polymorfismu glutathion S-transfer\u00E1zy"@cs . "Karami, Sara" . . . "Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms" . . . . "2"^^ . . "392316" . . . "Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms"@en . "RIV/61989592:15110/08:00006194" . "Carcinogenesis" . "10"^^ . "This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this association could be modified by glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genotypes. About 1097 RCC cases and 1476 controls from Central and Eastern Europe were interviewed to collect data on lifetime occupational histories. Occupational information for jobs held for at least 12 months duration was coded for pesticide exposures and assessed for frequency and intensity of exposure. GSTM1 and GSTT1 gene deletions were analyzed using TaqMan assays. A significant increase in RCC risk was observed among subjects ever exposed to pesticides [odds ratio (OR): 1.60; 95% confidence interval (CI): 1.00-2.55]. After stratification by genotypes, increased risk was observed among exposed subjects with at least one GSTM1 active allele (OR: 4.00; 95% CI: 1.55-10.33) but not among exposed subjects with two GSTM1" . "Mates, Dana" . "Janout, Vladim\u00EDr" . "O, P(NR9029)" . . . . "15110" . . "29" . . "Navr\u00E1tilov\u00E1, Marie" . "Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms"@en . "This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this association could be modified by glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genotypes. About 1097 RCC cases and 1476 controls from Central and Eastern Europe were interviewed to collect data on lifetime occupational histories. Occupational information for jobs held for at least 12 months duration was coded for pesticide exposures and assessed for frequency and intensity of exposure. GSTM1 and GSTT1 gene deletions were analyzed using TaqMan assays. A significant increase in RCC risk was observed among subjects ever exposed to pesticides [odds ratio (OR): 1.60; 95% confidence interval (CI): 1.00-2.55]. After stratification by genotypes, increased risk was observed among exposed subjects with at least one GSTM1 active allele (OR: 4.00; 95% CI: 1.55-10.33) but not among exposed subjects with two GSTM1"@en . . "Hung J, Rayjean" . . "Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms" . . . "Stewart, T." . . "Karcinom z ledvinn\u00FDch bun\u011Bk, pracovn\u00ED expozice pesticid\u016Fm a modifikace polymorfismu glutathion S-transfer\u00E1zy"@cs . "Rothman, Nathaniel" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "0143-3334" . "[272DC2E8E806]" . "5"^^ . "CI, confidence interval; GST, glutathione S-transferase; OR, odds ratio; RCC, renal cell carcinoma"@en .