. "Remodelace kosti, \u010D\u00E1sticov\u00E1 nemoc a individu\u00E1ln\u00ED vn\u00EDmavost k periprotetick\u00E9 osteol\u00FDze"@cs . "RIV/61989592:15110/08:00006107!RIV09-MZ0-15110___" . "Gallo, Ji\u0159\u00ED" . . . "Remodelace kosti, \u010D\u00E1sticov\u00E1 nemoc a individu\u00E1ln\u00ED vn\u00EDmavost k periprotetick\u00E9 osteol\u00FDze"@cs . "Bone remodelling, particle disease and individual susceptibility to periprosthetic osteolysis." . . "Bone remodelling is a tightly coupled process consisting of repetitive cycles of bone resorption and formation. Both processes are governed by mechanical signals, which operate in conjunction with local, and systemic factors in a discrete anatomic structure designated a basic multicellular unit (BMU). The microenvironment around total joint arthroplasty is a dynamic and complex milieu influenced by the chemical and physical stimuli associated with servicing the prosthesis. A key factor limiting the longevity of the prosthesis is polyethylene wear, which induces particle disease, and this may lead to increased and prolonged activity of BMUs resulting in periprosthetic osteolysis. Several pathways regulating BMU function have been reported in the past, including RANKL/RANK/OPG/TRAF6, TNF-\u03B1/TNFR/TRAF1, and IL-6/CD126/JAK/STAT. Moreover, the expression and functional activity of all these molecules can be affected by variations in their genes. These may explain the differences in severity of bone def" . "Bone remodelling, particle disease and individual susceptibility to periprosthetic osteolysis."@en . . "4"^^ . . . . . "0862-8408" . "Bone remodelling is a tightly coupled process consisting of repetitive cycles of bone resorption and formation. Both processes are governed by mechanical signals, which operate in conjunction with local, and systemic factors in a discrete anatomic structure designated a basic multicellular unit (BMU). The microenvironment around total joint arthroplasty is a dynamic and complex milieu influenced by the chemical and physical stimuli associated with servicing the prosthesis. A key factor limiting the longevity of the prosthesis is polyethylene wear, which induces particle disease, and this may lead to increased and prolonged activity of BMUs resulting in periprosthetic osteolysis. Several pathways regulating BMU function have been reported in the past, including RANKL/RANK/OPG/TRAF6, TNF-\u03B1/TNFR/TRAF1, and IL-6/CD126/JAK/STAT. Moreover, the expression and functional activity of all these molecules can be affected by variations in their genes. These may explain the differences in severity of bone def"@en . . "Bone remodelling, particle disease and individual susceptibility to periprosthetic osteolysis."@en . . "4"^^ . . "Physiological Research (print)" . . . "Pet\u0159ek, Martin" . . "15110" . . "Bone remodelling, particle disease and individual susceptibility to periprosthetic osteolysis." . "Remodelace kosti je komplexn\u00ED proces spo\u010D\u00EDvaj\u00EDc\u00ED v opakovan\u00FDch cyklech kostn\u00ED resorpce a v\u00FDstavby. Ob\u011B tyto slo\u017Eky jsou \u0159\u00EDzeny mechanick\u00FDmi sign\u00E1ly spolu s dal\u0161\u00EDmi lok\u00E1ln\u00EDmi a syst\u00E9mov\u00FDmi faktory v mikroanatomick\u00E9 struktu\u0159e ozna\u010Dovan\u00E9 jako ?z\u00E1kladn\u00ED mnohobun\u011B\u010Dn\u00E1 jednotka? (BMU). Mikroprost\u0159ed\u00ED v okol\u00ED um\u011Bl\u00E9 kloubn\u00ED n\u00E1hrady je z\u00E1visl\u00E9 na chemick\u00FDch a fyzik\u00E1ln\u00EDch sign\u00E1lech, kter\u00E9 jsou d\u016Fsledkem pou\u017E\u00EDv\u00E1n\u00ED prot\u00E9zy. Kl\u00ED\u010Dov\u00FDm faktorem omezuj\u00EDc\u00EDm trvanlivost prot\u00E9zy je ot\u011Br polyethylenu, kter\u00FD m\u016F\u017Ee indukovat \u010D\u00E1sticovou nemoc a v\u00E9st tak a\u017E periprotetick\u00E9 osteol\u00FDze. Byla pops\u00E1na \u0159ada sign\u00E1ln\u00EDch drah, kter\u00E9 reguluj\u00ED funkci BMU, jako nap\u0159. RANKL/RANK/OPG/TRAF6, TNF-\u03B1/TNFR/TRAF1 a IL-6/CD126/JAK/STAT. Exprese a funk\u010Dn\u00ED aktivita v\u0161ech uveden\u00FDch molekul m\u016F\u017Ee b\u00FDt nav\u00EDc ovlivn\u011Bna variabilitou v jejich genech. Tato skute\u010Dnost m\u016F\u017Ee vysv\u011Btlit rozd\u00EDly v z\u00E1va\u017Enosti kostn\u00EDch defekt\u016F mezi pacienty s identickou prot\u00E9zou a podobnou m\u00EDrou ot\u011Bru polyethylenu. Tato data proto podporuj\u00ED teorii individu\u00E1ln\u00ED vn\u00EDmavosti k selh"@cs . . . "57" . "358373" . "RIV/61989592:15110/08:00006107" . . "[207310B50E58]" . "Mr\u00E1zek, Franti\u0161ek" . "Ra\u0161ka, Milan" . "3" . . "CZ - \u010Cesk\u00E1 republika" . "periprosthetic osteolysis; particle disease; basic multicellular unit; osteoclast; osteoblast"@en . . "11"^^ . . "P(NR9490), Z(MSM6198959223)" .