"3"^^ . "Chemick\u00E9 listy" . "435281" . "0009-2770" . "Sta\u0148kov\u00E1, Marie" . "I" . "101" . . . . "V \u010Dl\u00E1nku jsou uvedeny mo\u017Enosti z\u00E1chytu a identifikace vybran\u00FDch antidepresiv nov\u00FDch generac\u00ED (maprotilin, mianserin, trazodon, milnacipran, mirtazapin, moclobemid, citalopram, fluoxetin, fluvoxamin, paroxetin, sertalin a venlafaxin) v biologick\u00E9m materi\u00E1lu. Z\u00E1chyt a identifikace v pou\u017Eit\u00E9m uspo\u0159\u00E1d\u00E1n\u00ED metod TLC a GC-MS jsou dostate\u010Dn\u011B citliv\u00E9 a polehliv\u00E9 pro v\u011Bt\u0161inu sledovan\u00FDch antidepresiv. Pro \u00FA\u010Dely kvantitativn\u00ED anal\u00FDzy metodou GC-MS byla pou\u017Eita izolace sledvoan\u00FDch antidepresiv z ibologick\u00E9ho materi\u00E1lu (krev, s\u00E9rum) extrakc\u00ED tuhou f\u00E1z\u00ED (SPEC-DAU) s postupem modifikovan\u016F\u00FDm pro bazick\u00E9 l\u00E1tky. Metoda je u v\u0161ech sledovan\u00FDch AD dostate\u010Dn\u011B cfitliv\u00E1 pro p\u0159\u00EDpady akutn\u00EDch intoxikac\u00ED a u v\u011Bt\u0161iny antidepresiv (citalopram, fluoxetin, fluvoxamin, mianserin, maprotilin, mirtazapin, moclobemid, sertralin, trazodon a venlafaxin) citliv\u00E1 i pro jejich stanoven\u00ED v rozp\u011Bt\u00ED teraputick\u00FDch hladin."@cs . . "7"^^ . "Mo\u017Enosti diagnostiky intoxikac\u00ED antidepres\u00EDv"@cs . . . . . "[E33F32D097BA]" . "V \u010Dl\u00E1nku jsou uvedeny mo\u017Enosti z\u00E1chytu a identifikace vybran\u00FDch antidepresiv nov\u00FDch generac\u00ED (maprotilin, mianserin, trazodon, milnacipran, mirtazapin, moclobemid, citalopram, fluoxetin, fluvoxamin, paroxetin, sertalin a venlafaxin) v biologick\u00E9m materi\u00E1lu. Z\u00E1chyt a identifikace v pou\u017Eit\u00E9m uspo\u0159\u00E1d\u00E1n\u00ED metod TLC a GC-MS jsou dostate\u010Dn\u011B citliv\u00E9 a polehliv\u00E9 pro v\u011Bt\u0161inu sledovan\u00FDch antidepresiv. Pro \u00FA\u010Dely kvantitativn\u00ED anal\u00FDzy metodou GC-MS byla pou\u017Eita izolace sledvoan\u00FDch antidepresiv z ibologick\u00E9ho materi\u00E1lu (krev, s\u00E9rum) extrakc\u00ED tuhou f\u00E1z\u00ED (SPEC-DAU) s postupem modifikovan\u016F\u00FDm pro bazick\u00E9 l\u00E1tky. Metoda je u v\u0161ech sledovan\u00FDch AD dostate\u010Dn\u011B cfitliv\u00E1 pro p\u0159\u00EDpady akutn\u00EDch intoxikac\u00ED a u v\u011Bt\u0161iny antidepresiv (citalopram, fluoxetin, fluvoxamin, mianserin, maprotilin, mirtazapin, moclobemid, sertralin, trazodon a venlafaxin) citliv\u00E1 i pro jejich stanoven\u00ED v rozp\u011Bt\u00ED teraputick\u00FDch hladin." . "Kurka, Petr" . "The article presents the possibilities of identification of selected antidepressants of new generations in biological materials. Identification of the drugs by TLC and GC-MS after ether extraction from biological materials (urine, stomach content) was tested. The detection is sensitive and reliable for most of the drugs. For quantitative GC-MS analysis, the drugs were isolated from blood or serum by solid phase extraction (SPE). The recovery of most drugs is over 70%. Limits of detection (LOD, 3 S/N) as well as limits of quantification (LOQ, 10 S/N) have been determined. The LOD are 0.5-2 ng 1 for citalopram, maprotiline, mianserine, mirtazapine, moclobemide, sertraline and venlafaxine, 15 ng 1 for fluoxetine and milnacipran and 50 ng 1 for fluvoxamine, paroxetine and trazodone. LOQ are 2-5 ng1 for citalopram, maprotiline, mianserine, mirtazapine, moclobemide, sertraline and 100 ng 1 for fluvoxamine, paroxetine and trazodone. For all the monitored drugs, the method is sufficiently sensitive in acute intoxications and for most of the drugs also in determination of therapeutic levels."@en . . "Mo\u017Enosti diagnostiky intoxikac\u00ED antidepres\u00EDv" . "15110" . "Mo\u017Enosti diagnostiky intoxikac\u00ED antidepres\u00EDv"@cs . . "CZ - \u010Cesk\u00E1 republika" . "The Possibilities of Diagnostics in Antidepressant Intoxications"@en . . "RIV/61989592:15110/07:10223811!RIV12-MSM-15110___" . . . . "101" . "RIV/61989592:15110/07:10223811" . . "2"^^ . . "Mo\u017Enosti diagnostiky intoxikac\u00ED antidepres\u00EDv" . "GC-MS; TLC; identification; antidepressants"@en . "The Possibilities of Diagnostics in Antidepressant Intoxications"@en . "Ondra, Peter" .