. . "[CFA61675FFBC]" . . . . "444291" . "RIV/61989592:15110/07:00006074" . . "P\u0159\u00EDprava a vyhodnocen\u00ED DNA vakc\u00EDn"@cs . "C\u00EDlem t\u00E9to pr\u00E1ce bylo studium efektu muk\u00F3zn\u00ED a parenter\u00E1ln\u00ED aplikace DNA vakc\u00EDny a rekombinantn\u00ED proteinov\u00E9 vakc\u00EDny odvozen\u00FDch od proteinu tepeln\u00E9ho \u0161oku 90kDa (hsp90) z Candida albicans u modelov\u00E9 syst\u00E9mov\u00E9 a vagin\u00E1ln\u00ED kandid\u00F3zy my\u0161\u00ED. Kandid\u00F3za, infekce zp\u016Fsoben\u00E1 mykotick\u00FDm p\u016Fvodcem rodu Candida, p\u0159edstavuje z\u00E1va\u017En\u00FD medic\u00EDnsk\u00FD probl\u00E9m. Klinicky nejv\u00FDznamn\u011Bj\u0161\u00EDm p\u016Fvodcem je st\u00E1le druh C. albicans. U vn\u00EDmav\u00FDch jedinc\u016F m\u016F\u017Ee kandid\u00F3za prob\u00EDhat pod obrazem syst\u00E9mov\u00E9 nebo muk\u00F3zn\u00ED formy. Pacienti se syst\u00E9movou kandid\u00F3zou, u kter\u00FDch byla prok\u00E1z\u00E1na vysok\u00E1 hladina protil\u00E1tek rozli\u0161uj\u00EDc\u00EDch kandidov\u00FD hsp90, m\u011Bli v\u00FDrazn\u011B lep\u0161\u00ED progn\u00F3zu. Pozorov\u00E1n\u00ED bylo potvrzeno i na zv\u00ED\u0159ec\u00EDch modelech, v nich\u017E protektivn\u00ED hsp90-specifick\u00E9 protil\u00E1tky byly indukov\u00E1ny imunizac\u00ED rekombinantn\u00EDm proteinem hsp90 nebo pasivn\u00EDm p\u0159enosem specifick\u00FDch protil\u00E1tek ze s\u00E9ra jin\u00E9ho zv\u00ED\u0159ete."@cs . . . "1"^^ . "DNA vaccine; plasmid; hsp90; recombinant protein; Candida albicans; candidiasis"@en . "Preparation and Evaluation of DNA Vaccines"@en . "C\u00EDlem t\u00E9to pr\u00E1ce bylo studium efektu muk\u00F3zn\u00ED a parenter\u00E1ln\u00ED aplikace DNA vakc\u00EDny a rekombinantn\u00ED proteinov\u00E9 vakc\u00EDny odvozen\u00FDch od proteinu tepeln\u00E9ho \u0161oku 90kDa (hsp90) z Candida albicans u modelov\u00E9 syst\u00E9mov\u00E9 a vagin\u00E1ln\u00ED kandid\u00F3zy my\u0161\u00ED. Kandid\u00F3za, infekce zp\u016Fsoben\u00E1 mykotick\u00FDm p\u016Fvodcem rodu Candida, p\u0159edstavuje z\u00E1va\u017En\u00FD medic\u00EDnsk\u00FD probl\u00E9m. Klinicky nejv\u00FDznamn\u011Bj\u0161\u00EDm p\u016Fvodcem je st\u00E1le druh C. albicans. U vn\u00EDmav\u00FDch jedinc\u016F m\u016F\u017Ee kandid\u00F3za prob\u00EDhat pod obrazem syst\u00E9mov\u00E9 nebo muk\u00F3zn\u00ED formy. Pacienti se syst\u00E9movou kandid\u00F3zou, u kter\u00FDch byla prok\u00E1z\u00E1na vysok\u00E1 hladina protil\u00E1tek rozli\u0161uj\u00EDc\u00EDch kandidov\u00FD hsp90, m\u011Bli v\u00FDrazn\u011B lep\u0161\u00ED progn\u00F3zu. Pozorov\u00E1n\u00ED bylo potvrzeno i na zv\u00ED\u0159ec\u00EDch modelech, v nich\u017E protektivn\u00ED hsp90-specifick\u00E9 protil\u00E1tky byly indukov\u00E1ny imunizac\u00ED rekombinantn\u00EDm proteinem hsp90 nebo pasivn\u00EDm p\u0159enosem specifick\u00FDch protil\u00E1tek ze s\u00E9ra jin\u00E9ho zv\u00ED\u0159ete." . . . . "RIV/61989592:15110/07:00006074!RIV09-MZ0-15110___" . . "15110" . "P\u0159\u00EDprava a vyhodnocen\u00ED DNA vakc\u00EDn" . . . "The aim of this thesis was to study the effects of mucosal and parenteral application of a DNA vaccine and a recombinant vaccine derived from Candida albicans heat shock protein 90 kDa (SP90) using a mouse model of systemic and vaginal candidiasis. Candidiasis infections caused by the Candida fungus are a significant medical problem. Clinically the most prominent etiological agent remains the C. albicans species. In susceptible persons the candidiasis could occurs in either systemic or mucosal forms. Patients with systemic candidiasis and a high level of antibodies against (hsp90), have a better prognosis. This observation has been confirmed in animal models where protective hsp90-specific antibodies are induced by vaccination with the recombinant protein hsp90 of C. albicans or by the passive transfer of the specific antibodies from the serum of other animals."@en . "P\u0159\u00EDprava a vyhodnocen\u00ED DNA vakc\u00EDn"@cs . "1"^^ . . . "Preparation and Evaluation of DNA Vaccines"@en . . . "P\u0159\u00EDprava a vyhodnocen\u00ED DNA vakc\u00EDn" . "B\u011Bl\u00E1kov\u00E1, Jana" . "P(NI7538)" .