"C\u00EDle: Stanoven\u00ED voln\u00FDch plazmatick\u00FDch metanefrin\u016F se jev\u00ED jako nejp\u0159esn\u011Bj\u0161\u00ED metoda v biochemick\u00E9 diagnostice feochromocytomu, ale nen\u00ED zn\u00E1ma jejich efektivita u neselektovan\u00FDch pacient\u016F s n\u00EDzkou pretestovou pravd\u011Bpodobnost\u00ED. Metodika: P\u0159i pr\u016F\u0159ezov\u00E9 multicentrick\u00E9 studii zahrnuj\u00EDc\u00ED 1260 subjekt\u016F jsme hodnotili diagnostickou efektivitu plazmatick\u00E9ho metanefrinu a normetanefrinu u pacient\u016F s akcelerovanou hypertenz\u00ED, paroxysm\u00E1ln\u00ED hypertenz\u00ED, v\u00FDskytem %22flushe%22 a rovn\u011B\u017E u men\u0161\u00EDho po\u010Dtu pacient\u016F s incidentalomem nadledviny a genetickou predispozic\u00ED pro feochromocytom. V\u00FDsledky: Feochromocytom byl diagnostikov\u00E1n a histologicky prok\u00E1z\u00E1n u 25 subjekt\u016F (2%), u ostatn\u00EDch 1235 nebyla dlouhodob\u00FDm sledov\u00E1n\u00EDm ani zobrazovac\u00EDmi metodami diagn\u00F3za prok\u00E1z\u00E1na. Kombinovan\u00FD test plazmatick\u00FDch metanefrin\u016F se uk\u00E1zal jako vysoce senzitivn\u00ED (100%) a specifick\u00FD (96,7%) test s negativn\u00ED prediktivn\u00ED hodnotou 100%. Z\u00E1v\u011Br: Uspokojiv\u00E1 diagnostick\u00E1 efektivita voln\u00FDch plazmatick\u00FDch metanefrin\u016F umo\u017E\u0148uje jejich pou\u017Eit\u00ED jak"@cs . "Laz\u00E1rov\u00E1, Marie" . "Stejskal, David" . "0263-6352" . . "Journal of Hypertension" . . . . . . . "La\u010D\u0148\u00E1k, Bo\u0159ek" . "Free plasma metanephrines as a screeining test for pheochromocytoma in low-risk patients"@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Free plasma metanephrines as a screeining test for pheochromocytoma in low-risk patients" . . "1"^^ . "Free plasma metanephrines as a screeining test for pheochromocytoma in low-risk patients"@en . "Kadalov\u00E1, Lenka" . "[D5CB79A8CF3B]" . "Objectives: Detection of free plasma metanephrines seems to be the most exact method for biochemical diagnosis of pheochromocytonoma, but their diagnostic efficacy in the common low-risk clinical settings is debated. Methods: A cross-sectional multicentre study including 1260 subjects assessed the diagnostic efficacy of free plasma metanephrine and normetanephrine in low-risk patients screened for resistant or markedly accelerated hypertension, paroxysmal hypertension, %22flushes%22, and, in a small proportion, for adrenal incidentaloma or genetic predisposition to pheochromocytoma. Results: Pheochromocytoma was identified and verified by histology in 25 subjects (2%), with the diagnosis not confirmed by long-ter, follow-up or use of imaging techniques in the remaining 1235 individuals. The combined assay of free plasma metanephrines was a highly sensitive (100%) and specific (96,7%) measure, yielding a negative predictive value of 100%. Conclusion: The satisfactory diagnostic efficacy of fr" . "V\u00E1clav\u00EDk, Jan" . "25" . "hypertension; metanephrine; metanephrines; normetanephrine; pheochromocytoma; secondary hypertension"@en . "Jano\u0161ov\u00E1, Marie" . "RIV/61989592:15110/07:00004443!RIV08-MSM-15110___" . "Free plasma metanephrines as a screeining test for pheochromocytoma in low-risk patients" . "Voln\u00E9 plazmatick\u00E9 metanefriny jako skr\u00EDningov\u00FD test pro feochromocytom v neselektovan\u00E9 populaci pacient\u016F s n\u00EDzk\u00FDm pretestov\u00FDm rizikem"@cs . . . "1427 - 1431" . "422599" . "Objectives: Detection of free plasma metanephrines seems to be the most exact method for biochemical diagnosis of pheochromocytonoma, but their diagnostic efficacy in the common low-risk clinical settings is debated. Methods: A cross-sectional multicentre study including 1260 subjects assessed the diagnostic efficacy of free plasma metanephrine and normetanephrine in low-risk patients screened for resistant or markedly accelerated hypertension, paroxysmal hypertension, %22flushes%22, and, in a small proportion, for adrenal incidentaloma or genetic predisposition to pheochromocytoma. Results: Pheochromocytoma was identified and verified by histology in 25 subjects (2%), with the diagnosis not confirmed by long-ter, follow-up or use of imaging techniques in the remaining 1235 individuals. The combined assay of free plasma metanephrines was a highly sensitive (100%) and specific (96,7%) measure, yielding a negative predictive value of 100%. Conclusion: The satisfactory diagnostic efficacy of fr"@en . . "Vl\u010Dek, Petr" . . . "5"^^ . "Fry\u0161\u00E1k, Zden\u011Bk" . "Voln\u00E9 plazmatick\u00E9 metanefriny jako skr\u00EDningov\u00FD test pro feochromocytom v neselektovan\u00E9 populaci pacient\u016F s n\u00EDzk\u00FDm pretestov\u00FDm rizikem"@cs . "S" . . "RIV/61989592:15110/07:00004443" . "15110" . . . "7" . "Jedelsk\u00FD, Libor" . "9"^^ .