"Cytotoxicita deriv\u00E1t\u016F kolchicinu v prim\u00E1rn\u00EDch kultur\u00E1ch lidsk\u00FDch hepatocyt\u016F"@cs . "Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes" . "Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes"@en . "Dvo\u0159\u00E1k, Zden\u011Bk" . . . "1213-8118" . "Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes" . . "47-52" . "151" . "Ulrichov\u00E1, Jitka" . "1" . "Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes"@en . "RIV/61989592:15110/07:00004415" . "RIV/61989592:15110/07:00004415!RIV08-MSM-15110___" . "4"^^ . "CZ - \u010Cesk\u00E1 republika" . "6"^^ . "Z(MSM6198959216)" . "Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes"@en . "\u0160im\u00E1nek, Vil\u00EDm" . . "Colchicine derivatives; Toxicity; Human hepatocytes"@en . . "Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes" . "Weyhenmeyer, Roland" . . "3"^^ . . "[27443E2FCBAE]" . . . . . . "Biomedical Papers" . . "15110" . . . "Cytotoxicita deriv\u00E1t\u016F kolchicinu v prim\u00E1rn\u00EDch kultur\u00E1ch lidsk\u00FDch hepatocyt\u016F"@cs . "\u00DAvod: Kolchicin byl po stalet\u00ED vyu\u017E\u00EDv\u00E1n v l\u00E9\u010Db\u011B dny. D\u00EDky sv\u00E9 toxicit\u011B ale vykazuje \u0159adu vedlej\u0161\u00EDch \u00FA\u010Dink\u016F. N\u00E1hrada kolchicinu m\u00E9n\u011B toxick\u00FDm, ale farmakologicky aktivn\u00EDm deriv\u00E1tem by mohla b\u00FDt \u0159e\u0161en\u00EDm tohoto nedostatku. C\u00EDl: C\u00EDlem pr\u00E1ce bylo studovat cytotoxicitu 17 deriv\u00E1t\u016F kolchicinu. Metody: Experiment\u00E1ln\u00EDm modelem byly prim\u00E1rn\u00ED kultury lidsk\u00FDch hepatocyt\u016F. P\u0159ed testov\u00E1n\u00EDm byly stanoveny biochemick\u00E9 parametry d\u00E1rc\u016F jater a stanovena toxikologick\u00E1 odpov\u011B\u010F kultur. Toxicita byla sledov\u00E1na po 24 h inkubace s testovan\u00FDmi l\u00E1tkami v koncentrac\u00EDch 1 ? 100 mM. Byla stanovena aktivita lakt\u00E1t dehydrogenasy (LDH) v m\u00E9diu, sekrece albuminu a aktivity mitochondri\u00E1ln\u00EDch dehydrogenas MTT. V\u00FDsledky: LDH a MTT byly m\u00E9n\u011B citliv\u00E9 parametry ne\u017E sekrece albuminu pro sledov\u00E1n\u00ED cytotoxicity deriv\u00E1t\u016F kolchicinu. L\u00E1tky s ni\u017E\u0161\u00ED antimitotickou aktivitou byly m\u00E9n\u011B toxick\u00E9. Z\u00E1v\u011Br: Jeliko\u017E lidsk\u00E9 hepatocyty v kultu\u0159e jsou neproliferuj\u00EDc\u00ED bu\u0148ky, jsou m\u00E9n\u011B citliv\u00E9 v\u016F\u010Di tropolonov\u00FDm alkaloid\u016Fm ve srovn\u00E1n\u00ED s bu\u0148kami proliferuj\u00EDc\u00EDmi."@cs . "415554" . . .