. "V\u00FDznam polymorfismu cytochromu P450 3A4 v l\u00E9\u010Db\u011B cyklosporinem a takrolimem."@cs . "\u010Euricov\u00E1, J." . "Grundmann, Milan" . "CZ - \u010Cesk\u00E1 republika" . . "V\u00FDznam polymorfismu cytochromu P450 3A4 v l\u00E9\u010Db\u011B cyklosporinem a takrolimem." . "[BDD925249C55]" . . . "460806" . "V\u00FDznam polymorfismu cytochromu P450 3A4 v l\u00E9\u010Db\u011B cyklosporinem a takrolimem." . . . "1212-7973" . "V\u00FDznam polymorfismu cytochromu P450 3A4 v l\u00E9\u010Db\u011B cyklosporinem a takrolimem."@cs . "Klinick\u00E1 farmakologie a farmacie" . . "Imunosupres\u00EDvne lieky cyklospor\u00EDn (CsA) a takrolimus (Tac) s\u00FA \u0161iroko u\u017E\u00EDvan\u00E9 k zabr\u00E1neniu ak\u00FAtnej rejekcii \u0161tepu po org\u00E1novej transplant\u00E1cii. Klinick\u00E9 pou\u017Eitie t\u00FDchto inhib\u00EDtorov kalcineur\u00EDnu je komplikovan\u00E9 mnoh\u00FDmi ved\u013Eaj\u0161\u00EDmi \u00FA\u010Dinkami. CsA a Tac maj\u00FA \u00FAzky terapeutick\u00FD index a vykazuj\u00FA zna\u010Dn\u00FA interindividu\u00E1lnu variabilitu vo farmakokinetike. N\u00EDzka biologick\u00E1 dostupnos\u0165 CsA a Tac je s\u010Dasti pripisovan\u00E1 interindividu\u00E1lnej variabilite v expresii metabolick\u00E9ho enz\u00FDmu cytochr\u00F3mu P450 3A. G\u00E9ny pre CYP 450 3A4 a 3A5 podliehaj\u00FA genetick\u00E9mu polymorfizmu. V\u00FDsledky jednotliv\u00FDch \u0161t\u00FAdi\u00ED zaoberaj\u00FAcich sa dopadom CYP3A polymorfizmu na farmakokinetiku CsA a Tac s\u00FA jednozna\u010Dn\u00E9 u Tac, kde bol preuk\u00E1zan\u00FD vz\u0165ah medzi CYP3A polymorfizmom a zmenou farmakokinetiky Tac, u CsA s\u00FA v\u00FDsledky \u0161t\u00FAdi\u00ED kontroverzn\u00E9." . "Imunosupres\u00EDvne lieky cyklospor\u00EDn (CsA) a takrolimus (Tac) s\u00FA \u0161iroko u\u017E\u00EDvan\u00E9 k zabr\u00E1neniu ak\u00FAtnej rejekcii \u0161tepu po org\u00E1novej transplant\u00E1cii. Klinick\u00E9 pou\u017Eitie t\u00FDchto inhib\u00EDtorov kalcineur\u00EDnu je komplikovan\u00E9 mnoh\u00FDmi ved\u013Eaj\u0161\u00EDmi \u00FA\u010Dinkami. CsA a Tac maj\u00FA \u00FAzky terapeutick\u00FD index a vykazuj\u00FA zna\u010Dn\u00FA interindividu\u00E1lnu variabilitu vo farmakokinetike. N\u00EDzka biologick\u00E1 dostupnos\u0165 CsA a Tac je s\u010Dasti pripisovan\u00E1 interindividu\u00E1lnej variabilite v expresii metabolick\u00E9ho enz\u00FDmu cytochr\u00F3mu P450 3A. G\u00E9ny pre CYP 450 3A4 a 3A5 podliehaj\u00FA genetick\u00E9mu polymorfizmu. V\u00FDsledky jednotliv\u00FDch \u0161t\u00FAdi\u00ED zaoberaj\u00FAcich sa dopadom CYP3A polymorfizmu na farmakokinetiku CsA a Tac s\u00FA jednozna\u010Dn\u00E9 u Tac, kde bol preuk\u00E1zan\u00FD vz\u0165ah medzi CYP3A polymorfizmom a zmenou farmakokinetiky Tac, u CsA s\u00FA v\u00FDsledky \u0161t\u00FAdi\u00ED kontroverzn\u00E9."@cs . "Cytochrome P450 3A polymorphism and its importance in cyclosporine and tacrolimus therapy in transplanted patients"@en . "3-4" . "21" . . . "RIV/61989592:15110/07:00004373!RIV08-MSM-15110___" . . "4"^^ . "15110" . "The calcineurin inhibitors cyclosporine (CsA) and tacrolimus (Tac) are widely used in the prevention of acute rejection after solid organ transplantation. However, their clinical use is associated with many adverse reactions. The calcineurin inhibitors CsA and Tac have a narrow therapeutic index and show highly variable pharmacokinetics. The low CsA and Tac bioavailability has been attributed to interindividual differences in the expression of the metabolizing enzyme cytochrome P450 3A. The genes for CYP3A4 and 3A5 undergo genetic polymorphism. The results of many studies focusing on the impact of CYP 3A polymorphism on CsA and Tac pharmacokinetics are clear with Tac, where an association between CYP 3A polymorphism and the pharmacokinetic consequences has been shown. However, the results with CsA are controversial"@en . "1"^^ . . . . "RIV/61989592:15110/07:00004373" . "S" . "CYP3A; polymorphism; cyclosporine; tacrolimus; transplantation"@en . "Cytochrome P450 3A polymorphism and its importance in cyclosporine and tacrolimus therapy in transplanted patients"@en . "2"^^ . "133-136" . . . .