"53-58" . . "CZ - \u010Cesk\u00E1 republika" . "425004" . "2"^^ . "Huntingtonova choroba a steroidn\u00ED receptory"@cs . "Huntingtonova choroba a steroidn\u00ED receptory"@cs . "4"^^ . "Huntington?s disease (HD); steroid hormone receptors (SHR); clinical picture"@en . . . "[EE69F658DC5C]" . "RIV/61989592:15110/07:00004219" . . . "151" . "Background: Steroid hormone receptors constitute a special group of receptors having a wide range of efficiency and distribution in the body. Androgen and estrogen receptors, and their expression in the body, are linked with attributes such as reproduction control and sexual behaviour, but their relation with behavioural models, perception, memory and stress remain unclear to date. Purpose: In this project we aim to focus on monitoring the expressive influence of steroid hormone receptors on embryonic tissues and subsequently, expand our study to include the expression on adult tissues such as the CNS and to monitor the developmental aspects and relations pertaining to neurodegenerative disorders, such as Huntington?s disease. Material and Methods: We shall rely on immuno-histochemistry, immuno-fluorescence and RT-PCR methods for detecting steroid hormone receptors and Huntingtin-associated protein 1 in the embryonic and adult tissue. Conclusion: mapping the expression of steroid receptors during deve" . . . . "RIV/61989592:15110/07:00004219!RIV08-MSM-15110___" . "15110" . "HUNTINGTON\u00B4S DISEASE AND STEROID HORMONE RECEPTORS" . "HUNTINGTON\u00B4S DISEASE AND STEROID HORMONE RECEPTORS"@en . . "David, Ond\u0159ej" . . "Bezdi\u010Dkov\u00E1, Marcela" . "Background: Steroid hormone receptors constitute a special group of receptors having a wide range of efficiency and distribution in the body. Androgen and estrogen receptors, and their expression in the body, are linked with attributes such as reproduction control and sexual behaviour, but their relation with behavioural models, perception, memory and stress remain unclear to date. Purpose: In this project we aim to focus on monitoring the expressive influence of steroid hormone receptors on embryonic tissues and subsequently, expand our study to include the expression on adult tissues such as the CNS and to monitor the developmental aspects and relations pertaining to neurodegenerative disorders, such as Huntington?s disease. Material and Methods: We shall rely on immuno-histochemistry, immuno-fluorescence and RT-PCR methods for detecting steroid hormone receptors and Huntingtin-associated protein 1 in the embryonic and adult tissue. Conclusion: mapping the expression of steroid receptors during deve"@en . "1213-8118" . "HUNTINGTON\u00B4S DISEASE AND STEROID HORMONE RECEPTORS"@en . . "Mol\u00EDkov\u00E1, Radka" . "Huntingtonova nemoc (HN) je d\u016Fsledek geneticky programovan\u00E9 degenerace mozkov\u00FDch bun\u011Bk, kter\u00E9 naz\u00FDv\u00E1me neurony. Tato degenerace zp\u016Fsobuje nekontrolovateln\u00E9 pohyby, ztr\u00E1tu kognitivn\u00EDch schopnost\u00ED a emo\u010Dn\u00ED poruchy. HN je d\u011Bdi\u010Dn\u00E1 choroba, p\u0159en\u00E1\u0161ena z rodi\u010D\u016F na d\u011Bti pomoci mutace v norm\u00E1ln\u00EDm genu. Ka\u017Ed\u00E9 d\u00EDt\u011B s rodi\u010Di trp\u00EDc\u00ED HN m\u00E1 pravd\u011Bpodobnost 50-50 zd\u011Bdit HN gen. N\u011Bkter\u00E9 \u010Dasn\u00E9 symptomy HN se projevuj\u00ED prudkou zm\u011Bnou n\u00E1lady, depresemi, podr\u00E1\u017Ed\u011Bnost\u00ED nebo probl\u00E9my s \u0159\u00EDzen\u00EDm auta, u\u010Den\u00EDm nov\u00FDch v\u011Bc\u00ED, pamatovan\u00EDm si nebo rozhodovan\u00EDm. Jakmile se nemoc rozvine, st\u00E1v\u00E1 se ot\u00E1zka koncentrace a intelektu st\u00E1le slo\u017Eit\u011Bj\u0161\u00ED, pacient m\u00EDv\u00E1 probl\u00E9my s p\u0159\u00EDjmem stravy a polyk\u00E1n\u00EDm (dysfagie). Rychlost rozvoje choroby a v\u011Bk v dob\u011B jej\u00EDho za\u010D\u00E1tku je u ka\u017Ed\u00E9ho \u010Dlov\u011Bka odli\u0161n\u00FD. Genetick\u00FD test spolu s kompletn\u00ED l\u00E9ka\u0159skou anamn\u00E9zou, neurologick\u00FDmi a laboratorn\u00EDmi testy, pom\u00E1haj\u00ED leka\u0159i diagnostikovat HN. Presymptomatick\u00E9 testov\u00E1n\u00ED je k dispozici pro osoby, kter\u00E9 jsou v rizikov\u00E9 skupin\u011B pro p\u0159enos HN genu. U 1- 3 % o"@cs . . "HUNTINGTON\u00B4S DISEASE AND STEROID HORMONE RECEPTORS" . . "B\u00E9barov\u00E1, Linda" . "6"^^ . "Biomedical Papers" . "1" . . "S" . .