"[782823F33FDC]" . . "Moullan, Norman" . "Szeszenia-Dabrowska, Neonila" . . . "Mates, Dana" . "aerodigestive tract cancers; DNA and cell cycle repair genes"@en . . "Hung, Rayjean J." . "Cancers of the upper aerodigestive tract (UADT), comprising the oral cavity, pharynx, larynx and oesophagus, account for 5.2% of all cancers cases worldwide. The major risk factors, tobacco and alcohol can directly or indirectly generate DNA damage, which if unrepaired can give rise to mutations, unregulated cell growth and apoptosis induction. To clarify the role of DNA repair and cell cycle control proteins in UADT cancer susceptibility, we studied the risk in relation to 28 SNPs in 18 DNA repair enzymes and 9 SNPs in 7 cell cycle control genes. A case-control study was conducted from 2000 to 2002 in six centers from Romania, Poland, Russia, Slovakia and the Czech Republic. Patients diagnosed with squamous cell carcinoma of the UADT (n=811) and controls with a recent diagnosis of diseases unrelated to tobacco and alcohol (n=1083) were recruited. For UADT cancer risk, associations were observed for the homozygous carriers of the variant alleles of MGMT L84F [odds ratio (OR) 2.35, 95% confidence inter"@en . . "Fabi\u00E1nov\u00E1, Elenonora" . "Hall, Janet" . "The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract"@en . "Chabrier, Amelie" . . "Vztah n\u00E1dor\u016F horn\u00EDho aerodigestivn\u00EDho traktu a variant v genech pro opravu DNA a bun\u011B\u010Dn\u00E9ho cyklu"@cs . "17"^^ . "The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract" . "410908" . "Zaridze, David" . "7"^^ . "Boffetta, Paolo" . . "RIV/61989592:15110/07:00004002!RIV08-MZ0-15110___" . "Canzian, Federico" . "Carcinogenesis" . . "Hashibe, Mia" . . "Janout, Vladim\u00EDr" . "28" . "Shangina, Oxana" . . "The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract"@en . "Cancers of the upper aerodigestive tract (UADT), comprising the oral cavity, pharynx, larynx and oesophagus, account for 5.2% of all cancers cases worldwide. The major risk factors, tobacco and alcohol can directly or indirectly generate DNA damage, which if unrepaired can give rise to mutations, unregulated cell growth and apoptosis induction. To clarify the role of DNA repair and cell cycle control proteins in UADT cancer susceptibility, we studied the risk in relation to 28 SNPs in 18 DNA repair enzymes and 9 SNPs in 7 cell cycle control genes. A case-control study was conducted from 2000 to 2002 in six centers from Romania, Poland, Russia, Slovakia and the Czech Republic. Patients diagnosed with squamous cell carcinoma of the UADT (n=811) and controls with a recent diagnosis of diseases unrelated to tobacco and alcohol (n=1083) were recruited. For UADT cancer risk, associations were observed for the homozygous carriers of the variant alleles of MGMT L84F [odds ratio (OR) 2.35, 95% confidence inter" . "1"^^ . "P(NR9029)" . "Brennan, Paul" . "665-671" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Bylo studov\u00E1no riziko vzniku n\u00E1dor\u016F horn\u00EDho aerodigestivn\u00EDho traktu ve vztahu k 28 SNP u 18 enzym\u016F opravuj\u00EDc\u00EDch DNA a 9 SNP u 7 gen\u016F kontroluj\u00EDc\u00EDch bun\u011B\u010Dn\u00FD cyklus. Byla zvolena forma studie p\u0159\u00EDpad\u016F a kontrol zahrnuj\u00EDc\u00ED 811 p\u0159\u00EDpad\u016F n\u00E1dor\u016F a 1083 kontroln\u00EDch osob."@cs . . . "Mckay, James" . "0143-3334" . "RIV/61989592:15110/07:00004002" . "3" . "Holcatova, Ivana" . "Vztah n\u00E1dor\u016F horn\u00EDho aerodigestivn\u00EDho traktu a variant v genech pro opravu DNA a bun\u011B\u010Dn\u00E9ho cyklu"@cs . . "Gaborieau, Val\u00E9rie" . "15110" . "The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract" .