"6"^^ . "New York" . . "Mikrotubul\u00E1rn\u00ED s\u00ED\u0165 v signalizaci glukokortikoidn\u00EDho a aryl uhlovod\u00EDkov\u00E9ho receptoru."@cs . "161"^^ . . . "[ED619B4AC9E4]" . "Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling" . "Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling"@en . "15110" . "Ulrichov\u00E1, Jitka" . . . . "485723" . . . . "Z(MSM6198959216)" . "Vilarem, M. J." . . "Maurel, Patrick" . "Pascussi, J. M." . . "Glucocorticoid receptor; Aryl hydrocarbon receptor; Microtubules; Cellular signaling; Drug metabolism"@en . . . "Mikrotubul\u00E1rn\u00ED s\u00ED\u0165 v signalizaci glukokortikoidn\u00EDho a aryl uhlovod\u00EDkov\u00E9ho receptoru."@cs . . . "3"^^ . "Glucocorticoid receptor (GR) and aryl hydrocarbon receptor (AhR) are two entirely different individuals, the former being a typical steroid receptor integrated in endogenous affairs, the latter being the first described xeno-receptor, so-called dioxin receptor. Interestingly, these two receptors share several common features: 1) involvement in essential cellular processes such as proliferation, differentiation, inflammatory response, and gene expression; 2) essential role in drug metabolism, i.e. direct and/or indirect control of phase I, II, and III enzymes expression. 3) mechanism of their action in terms of ligand binding, nuclear import and export, and proteasome-mediated degradation, the last feature serving as negative feedback. 4) The dependence of their activity on the status of microtubules network. Despite voluminous data published, the role of microtubules in GR signaling is still controversial. Crucial appears the distinction between proliferating versus non-proliferating cells. While pert"@en . . "Glucocorticoid receptor (GR) and aryl hydrocarbon receptor (AhR) are two entirely different individuals, the former being a typical steroid receptor integrated in endogenous affairs, the latter being the first described xeno-receptor, so-called dioxin receptor. Interestingly, these two receptors share several common features: 1) involvement in essential cellular processes such as proliferation, differentiation, inflammatory response, and gene expression; 2) essential role in drug metabolism, i.e. direct and/or indirect control of phase I, II, and III enzymes expression. 3) mechanism of their action in terms of ligand binding, nuclear import and export, and proteasome-mediated degradation, the last feature serving as negative feedback. 4) The dependence of their activity on the status of microtubules network. Despite voluminous data published, the role of microtubules in GR signaling is still controversial. Crucial appears the distinction between proliferating versus non-proliferating cells. While pert" . "RIV/61989592:15110/06:00003511" . "Nova Science Publisher, Inc." . . "1-59454-619-3" . "Glukokortikoidn\u00ED receptor (GR) a aryl uhlovod\u00EDkov\u00FD receptor (AhR) jsou dv\u011B zcela odli\u0161n\u00E9 entity, prvn\u00ED z nich je typick\u00FD steroidn\u00ED receptor zapojen\u00FD do endogenn\u00EDch pochod\u016F, druh\u00FD z nich je prvn\u00ED popsan\u00FD xenoreceptor, tzv. dioxinov\u00FD receptor. Je zaj\u00EDmav\u00E9, \u017Ee tyto dva receptory sd\u00EDlej\u00ED n\u011Bkolik spole\u010Dn\u00FDch vlastnost\u00ED: 1) zapojen\u00ED do esenci\u00E1ln\u00EDch bun\u011B\u010Dn\u00FDch proces\u016F jak\u00FDmi jsou proliferace, diferenciace, z\u00E1n\u011Btliv\u00E1 reakce a exprese gen\u016F, 2) d\u016Fle\u017Eit\u00E1 \u00FAloha v metabolismu l\u00E9\u010Div, tj. p\u0159\u00EDm\u00E1 a/nebo nep\u0159\u00EDm\u00E1 regulace exprese biotransforma\u010Dn\u00EDch enzym\u016F f\u00E1ze I, II a III. 3) mechanismus jejich \u00FA\u010Dinku ve smyslu vazby ligandu, import a export do/z j\u00E1dra a protesomem \u0159\u00EDzen\u00E1 degradace, kter\u00E1 slou\u017E\u00ED jako negativn\u00ED regulace. 4) Z\u00E1vislost jejich aktivity na stavu mikrotubul\u00E1rn\u00ED s\u00EDt\u011B. Navzdory objemn\u00E9mu souboru publikovan\u00FDch dat je \u00FAloha mikrotubul\u00E1rn\u00ED s\u00EDt\u011B v signalizaci GR st\u00E1le kontroverzn\u00ED. Rozhoduj\u00EDc\u00ED se zd\u00E1 b\u00FDt odli\u0161nost proliferuj\u00EDc\u00EDch a neproliferuj\u00EDc\u00EDch bun\u011Bk. A\u010Dkoli poru\u0161en\u00ED mikrotubul\u00E1rn\u00ED s\u00EDt\u011B v bu\u0148k\u00E1ch lidsk\u00E9ho karcin"@cs . "Dvo\u0159\u00E1k, Zden\u011Bk" . "RIV/61989592:15110/06:00003511!RIV07-MSM-15110___" . "Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling" . . "Focus on Cellular Signaling Research" . "Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling"@en . . "29-54" . "Modriansk\u00FD, Martin" .