"89-93" . "Orolin, Jan" . "Anzenbacher, Pavel" . "silymarin; lipid metabolism"@en . "Vliv silymarinu a fenofibr\u00E1tu na lipidov\u00FD metabolismus"@cs . . "15110" . "Silymarinis used in supportive therapy of liver diseases and showed a positive effect on lipoprotein profile. Fenofibrete, drug used for its hypolipidemic effect, is a potent activator of PPAR alfa which plays a key role in lipid metabolism and homeostasis."@en . . "P(1P05OC065)" . . "RIV/61989592:15110/06:00003496!RIV07-MSM-15110___" . "Effects of silymarin and fenofibrate on lipid metabolism" . "80-239-7726-1" . . "Silymarin - standardizovan\u00FD extrakt ze semen Silybum marianum ( Asteraceae ) je zn\u00E1m\u00FD pro sv\u00E9 hepatoprotektivn\u00ED vlasnosti. V na\u0161ich studi\u00EDch jsme prok\u00E1zali i jeho pozitivn\u00ED vliv na lipoproteinov\u00FD profil. L\u00E9\u010Diva ze skupiny fibr\u00E1t\u016F, kter\u00E1 se pou\u017E\u00EDvaj\u00ED k l\u00E9\u010Db\u011B dyslipidemi\u00ED, jsou liganty jadern\u00E9ho receptoru PPARa, kter\u00FD pat\u0159\u00ED do rodiny nukle\u00E1rn\u00EDch receptor\u016F - nased\u00E1 na specifickou sekvenci na promotoru sv\u00FDch c\u00EDlov\u00FDch gen\u016F, co\u017E vede k aktivaci t\u011Bchto gen\u016F, jejich zp\u0159\u00EDstupn\u011Bn\u00ED pro transkripci a vznik mRNA. Mezi c\u00EDlov\u00E9 geny indukovan\u00E9 PPARa pat\u0159\u00ED \u0159ada enzym\u016F \u00FA\u010Dasn\u00EDc\u00EDch se beta- oxidace i gama-oxidace(CYP4A) mastn\u00FDch kyselin, \u010D\u00EDm\u017E p\u0159isp\u00EDv\u00E1 ke sn\u00ED\u017Een\u00ED hladiny TAG a jejich aterogenn\u00ED aktivity. C\u00EDlem t\u00E9to pr\u00E1ce bylo zjistit vliv silymarinu a fenofibr\u00E1tu na expresi PPARa na \u00FArovni proteinu a na expresi PPARa a jeho c\u00EDlov\u00FDch gen\u016F na \u00FArovni mRNA."@cs . "Effects of silymarin and fenofibrate on lipid metabolism"@en . "[B4614EA0A030]" . "Atherosklerosa" . . . . "Vliv silymarinu a fenofibr\u00E1tu na lipidov\u00FD metabolismus"@cs . "Jung, D." . . "\u0160kottov\u00E1, Nina" . "Effects of silymarin and fenofibrate on lipid metabolism"@en . . "5"^^ . "Silymarinis used in supportive therapy of liver diseases and showed a positive effect on lipoprotein profile. Fenofibrete, drug used for its hypolipidemic effect, is a potent activator of PPAR alfa which plays a key role in lipid metabolism and homeostasis." . "Effects of silymarin and fenofibrate on lipid metabolism" . "6"^^ . "RIV/61989592:15110/06:00003496" . "Praha" . . "Praha" . "Ve\u010De\u0159a, Rostislav" . . . "473374" . . . . . "4"^^ . . "Meyer, U. A." .