. "[B2B02A53F39B]" . . "OBJECTIVES: This review summarizes the involvement of sanguinarine and chelerythrine in cell cycle regulation and cell death in various cell lines. It is focused on their potential in the treatment of cancer. METHODS: We conducted a search of PubMed, ScienceDirect and Medline for papers on the molecular mechanisms of the biological activity of sanguinarine and chelerythrine published mainly from 1995 to 2006. RESULTS AND CONCLUSIONS: Our analysis of the published studies suggested that these alkaloids are not only good candidates for chemotherapeutic regimens but may also contribute to the development of successful immune therapies of some carcinomas due to their apoptotic potential. However, the complete signalling cascade in which sanguinarine and chelerythrine treatment induces apoptotic cell death is not yet understood. Overall, the results of recent studies suggest that sanguinarine and chelerythrine may be useful as agents in the management of cancer."@en . "473366" . "150" . . "OBJECTIVES: This review summarizes the involvement of sanguinarine and chelerythrine in cell cycle regulation and cell death in various cell lines. It is focused on their potential in the treatment of cancer. METHODS: We conducted a search of PubMed, ScienceDirect and Medline for papers on the molecular mechanisms of the biological activity of sanguinarine and chelerythrine published mainly from 1995 to 2006. RESULTS AND CONCLUSIONS: Our analysis of the published studies suggested that these alkaloids are not only good candidates for chemotherapeutic regimens but may also contribute to the development of successful immune therapies of some carcinomas due to their apoptotic potential. However, the complete signalling cascade in which sanguinarine and chelerythrine treatment induces apoptotic cell death is not yet understood. Overall, the results of recent studies suggest that sanguinarine and chelerythrine may be useful as agents in the management of cancer." . . "RIV/61989592:15110/06:00003482!RIV07-MSM-15110___" . "Z(MSM6198959216)" . "1213-8118" . . . "Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis" . "C\u00EDle: Tento souborn\u00FD \u010Dl\u00E1nek shrnuje studie v\u011Bnuj\u00EDc\u00ED se zapojen\u00ED sanguinarinu a chelerythrinu do regulace bun\u011B\u010Dn\u00E9ho cyklu a vlivu na bun\u011B\u010Dnou smrt u r\u016Fzn\u00FDch bun\u011B\u010Dn\u00FDch lini\u00ED. \u010Cl\u00E1nek je zam\u011B\u0159en na mo\u017En\u00E9 vyu\u017Eit\u00ED t\u011Bchto l\u00E1tek p\u0159i l\u00E9\u010Db\u011B rakoviny. Metody: Vyhledali jsme pr\u00E1ce v datab\u00E1z\u00EDch PubMed, ScienceDirect a Medline zam\u011B\u0159en\u00E9 na molekul\u00E1rn\u00ED mechanismus biologick\u00E9 aktivity sanguinarinu a chelerythrinu, kter\u00E9 byly publikov\u00E1ny v letech 1995 - 2006. V\u00FDsledky a z\u00E1v\u011Bry: V\u00FDsledky z pou\u017Eit\u00FDch publikac\u00ED nazna\u010Duj\u00ED, \u017Ee tyto alkaloidy nejsou pouze vhodn\u00FDmi kandid\u00E1ty pro chemoterapeutick\u00E9 vyu\u017Eit\u00ED, ale rovn\u011B\u017E mohou p\u0159isp\u011Bt k v\u00FDvoji vhodn\u00E9 imunn\u00ED l\u00E9\u010Dby n\u011Bkter\u00FDch typ\u016F rakovin d\u00EDky jejich apoptotick\u00E9 schopnosti. Nicm\u00E9n\u011B \u00FApln\u00E1 sign\u00E1ln\u00ED dr\u00E1ha, kterou sanguinarin a chelerythrin indukuje apoptotickou bun\u011B\u010Dnou smrt nen\u00ED dosud objasn\u011Bna. Z v\u00FDsledk\u016F ned\u00E1vn\u00FDch studi\u00ED lze soudit, \u017Ee sanguinarin a chelerythrin se m\u016F\u017Ee uplatnit jako l\u00E1tka p\u0159i l\u00E9\u010Db\u011B rakoviny."@cs . . . "Quaternary benzo[c]phenanthridine alkaloids; Cytotoxicity; Apoptosis; Cancer; Cell signalling; Proliferation"@en . . "Mal\u00EDkov\u00E1, Jana" . . "CZ - \u010Cesk\u00E1 republika" . . . . . "8"^^ . "3"^^ . "1" . "3"^^ . "Vliv sanguinarinu a chelerythrinu na bun\u011B\u010Dn\u00FD cyklus a apopt\u00F3zu."@cs . . "RIV/61989592:15110/06:00003482" . "5-12" . . "Zda\u0159ilov\u00E1, Ad\u00E9la" . "Hlobilkov\u00E1, Alice" . . . "Biomedical Papers" . "Vliv sanguinarinu a chelerythrinu na bun\u011B\u010Dn\u00FD cyklus a apopt\u00F3zu."@cs . "Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis"@en . . . "Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis" . "Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis"@en . "15110" .